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> Protein (NX_P62826)
Protein (NX_P62826)
Protein
Gene SymbolRAN to neXtProt (NX_P62826)
DescriptionGTP-binding nuclear protein Ran
Chromosome12
Location12q24.33 (131356424 ~ 131362223) to Ensembl
Sequene Features : Isoforms 1, Variants 16, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein localization to nucleolus
.intracellular transport of virus
.cell division
  + 21 more...
.androgen receptor binding
.poly(A) RNA binding
.GDP binding
  + 4 more...
.extracellular exosome
.recycling endosome
.RNA nuclear export complex
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 16 21
2014-09-19protein level
1 14 21
2014-05-27protein level
1 14 21
2014-02-25protein level
1 14 20
2013-12-09protein level
1 12 20
2013-11-01protein level
1 12 13
2013-09-12protein level
1 12 13
2013-08-17protein level
1 12 13
2013-07-15protein level
1 9 7
2013-06-11protein level
1 9 7
2013-02-12protein level
1 1 9
2012-12-20protein level
1 1 9
2012-10-30protein level
1 1 9
2012-10-07protein level
1 1 9
2012-08-24protein level
1 1 9
2012-07-28protein level
1 1 9
2012-06-08protein level
1 7 9
2012-05-07protein level
1 11 9
2012-04-10protein level
1 11 9
2012-01-13protein level
1 11 9
2011-12-20protein level
1 11 9
2011-11-11protein level
1 11 9
2011-08-23protein level
1 11 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62826-1
10 0 0 24407.5484
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286642,EBI-518823 BIRC5  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.mitotic spindle assembly
.establishment of chromosome localization
  + 19 more...
.chaperone binding
.cobalt ion binding
.cofactor binding
  + 12 more...
.chromosome passenger complex
.interphase microtubule organizing center
.midbody
  + 11 more...
2 EBI-286642,EBI-747310 IPO13  
  .protein import into nucleus .N/A .cytoplasm
.nucleus
3 EBI-286642,EBI-992720 RCC1  
  .cell division
.spindle assembly
.positive regulation of GTPase activity
  + 6 more...
.histone binding
.nucleosomal DNA binding
.Ran guanyl-nucleotide exchange factor activity
.chromatin binding
.nuclear membrane
.cytoplasm
.nucleoplasm
  + 3 more...
4 EBI-286642,EBI-591778 NUTF2  
  .protein export from nucleus
.protein import into nucleus, translocation
.Ran GTPase binding
.transporter activity
.extracellular exosome
.cytosol
.nuclear pore
5 EBI-286642,EBI-1207633 VRK2  
  .regulation of interleukin-1-mediated signaling pathway
.protein autophosphorylation
.regulation of MAPK cascade
  + 7 more...
.protein domain specific binding
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.protein complex
.mitochondrial membrane
.integral component of membrane
  + 4 more...
6 EBI-286642,EBI-286693 TNPO1  
  .viral process
.gene expression
.organelle organization
.protein import into nucleus, translocation
.poly(A) RNA binding
.nuclear localization sequence binding
.primary cilium
.extracellular exosome
.cytosol
  + 2 more...
7 EBI-286642,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland364
ascites175
bladder602
blood368
bone293
bone marrow471
brain384
cervix371
connective tissue73
ear124
embryonic tissue638
esophagus99
eye320
heart245
intestine275
kidney270
liver555
lung465
lymph1151
lymph node122
mammary gland290
mouth241
muscle206
nerve128
ovary394
pancreas337
parathyroid48
pharynx417
pituitary gland121
placenta247
prostate385
salivary gland1233
skin583
spleen374
stomach407
testis280
thymus200
thyroid128
tonsil1645
trachea77
umbilical cord508
uterus383
vascular522
Health State
TissuesTPM*
normal310
adrenal tumor553
bladder carcinoma682
breast (mammary gland) tumor397
cervical tumor492
chondrosarcoma120
colorectal tumor373
esophageal tumor115
gastrointestinal tumor244
germ cell tumor642
glioma167
head and neck tumor171
kidney tumor493
leukemia381
liver tumor843
lung tumor1080
lymphoma789
non-neoplasia62
ovarian tumor380
pancreatic tumor371
primitive neuroectodermal tumor of the CNS653
prostate cancer548
retinoblastoma689
skin tumor717
soft tissue/muscle tissue tumor447
uterine tumor255
Developmental Stage
TissuesTPM*
adult222
embryoid body686
blastocyst683
neonate450
fetus326
infant510
juvenile467
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75
adrenal gland99.2
appendix131.5
bone marrow111
cerebral cortex73.2
colon105.6
duodenum64.2
esophagus105.6
gallbladder70.2
heart muscle63.6
kidney63.9
liver45.1
lung63.3
lymph node168.7
ovary60
pancreas31
placenta98.4
prostate58.3
salivary gland37
skin59.1
small intestine67.3
spleen71.1
stomach69.2
testis124.9
thyroid gland68.7
urinary bladder94.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*601179, gene) Ras-related nuclear protein; RANOMIM


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