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> Protein (NX_P62837)
Protein (NX_P62837)
Protein
Gene SymbolUBE2D2 to neXtProt (NX_P62837)
DescriptionUbiquitin-conjugating enzyme E2 D2
Chromosome5
Location5q31.2 (138906016 ~ 139008018) to Ensembl
Sequene Features : Isoforms 2, Variants 13, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 13 1
2014-09-19protein level
2 13 1
2014-05-27protein level
2 13 2
2014-02-25protein level
2 13 2
2013-12-09protein level
2 13 2
2013-11-01protein level
2 13 1
2013-09-12protein level
2 13 1
2013-08-17protein level
2 13 1
2013-07-15protein level
2 6 0
2013-06-11protein level
2 6 0
2013-02-12protein level
2 1 1
2012-12-20protein level
1 1 1
2012-10-30protein level
1 1 1
2012-10-07protein level
1 1 1
2012-08-24protein level
1 0 1
2012-07-28protein level
1 0 1
2012-06-08protein level
1 4 1
2012-05-07protein level
1 3 1
2012-04-10protein level
1 3 1
2012-01-13protein level
1 3 1
2011-12-20protein level
1 3 1
2011-11-11protein level
1 3 1
2011-08-23protein level
1 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62837-1
0 0 4 16724.3757
NX_P62837-2
1 0 3 13625.8457
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347677,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
2 EBI-347677,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-347677,EBI-1647060 RNF43  
  .stem cell proliferation
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.Wnt receptor catabolic process
  + 3 more...
.ligase activity
.zinc ion binding
.frizzled binding
.ubiquitin-protein transferase activity
.integral component of plasma membrane
.plasma membrane
.endoplasmic reticulum membrane
.nuclear envelope
4 EBI-347677,EBI-2129250 ZNRF1  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.synaptic vesicle membrane
.cell junction
.membrane
  + 3 more...
5 EBI-347677,EBI-1058491 OTUB1  
  .negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
6 EBI-347677,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
7 EBI-347677,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
8 EBI-347677,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder167
blood49
bone69
bone marrow164
brain49
cervix144
connective tissue60
ear124
embryonic tissue145
esophagus49
eye105
heart111
intestine73
kidney61
liver43
lung89
lymph45
lymph node66
mammary gland85
mouth30
muscle18
nerve64
ovary128
pancreas117
pharynx49
pituitary gland121
placenta38
prostate52
salivary gland49
skin14
spleen18
stomach41
testis82
thymus37
thyroid42
tonsil58
uterus155
vascular38
Health State
TissuesTPM*
normal82
bladder carcinoma113
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma120
colorectal tumor71
esophageal tumor57
gastrointestinal tumor50
germ cell tumor60
glioma139
head and neck tumor7
kidney tumor43
leukemia105
liver tumor31
lung tumor77
lymphoma83
non-neoplasia62
ovarian tumor144
pancreatic tumor104
primitive neuroectodermal tumor of the CNS110
prostate cancer28
retinoblastoma86
skin tumor15
soft tissue/muscle tissue tumor87
uterine tumor110
Developmental Stage
TissuesTPM*
adult77
embryoid body200
blastocyst113
fetus73
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue48.5
adrenal gland48.3
appendix63.4
bone marrow48.9
cerebral cortex62.1
colon70.9
duodenum51.7
esophagus76.1
gallbladder54
heart muscle65.8
kidney46.6
liver31.6
lung50.5
lymph node103.8
ovary55.5
pancreas25.4
placenta57.2
prostate47.2
salivary gland33.4
skin37
small intestine51.6
spleen58.2
stomach47.8
testis99.5
thyroid gland73.8
urinary bladder71.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602962, gene) Ubiquitin-conjugating enzyme e2d 2; UBE2D2OMIM


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