Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P62875)
Protein (NX_P62875)
Protein
Gene SymbolPOLR2L to neXtProt (NX_P62875)
DescriptionDNA-directed RNA polymerases I, II, and III subunit RPABC5
Chromosome11
Location11p15.5 (837356 ~ 842545) to Ensembl
Sequene Features : Isoforms 1, Variants 3, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 3 2
2014-09-19protein level
1 3 2
2014-05-27protein level
1 3 2
2014-02-25protein level
1 3 2
2013-12-09protein level
1 2 2
2013-11-01protein level
1 2 2
2013-09-12protein level
1 2 2
2013-08-17protein level
1 2 2
2013-07-15protein level
1 1 0
2013-06-11protein level
1 1 0
2013-02-12protein level
1 1 0
2012-12-20protein level
1 1 0
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 1 0
2012-05-07protein level
1 1 0
2012-04-10protein level
1 1 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62875-1
3 0 0 7639.9651
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359527,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-359527,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
3 EBI-359527,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-359527,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
5 EBI-359527,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
6 EBI-359527,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
7 EBI-359527,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
8 EBI-359527,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
9 EBI-359527,EBI-1048085 RPAP1  
  .transcription from RNA polymerase II promoter .DNA-directed RNA polymerase activity
.DNA binding
.nucleus
10 EBI-359527,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland60
ascites25
bladder33
blood16
bone55
bone marrow61
brain21
cervix41
connective tissue20
ear124
embryonic tissue75
eye23
heart33
intestine38
kidney75
liver43
lung32
lymph22
lymph node44
mammary gland66
mouth15
muscle244
ovary9
pancreas93
parathyroid48
pituitary gland121
placenta35
prostate100
salivary gland197
skin47
stomach10
testis9
thyroid21
umbilical cord145
uterus60
vascular193
Health State
TissuesTPM*
normal55
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor42
germ cell tumor18
glioma93
head and neck tumor44
kidney tumor72
leukemia42
liver tumor41
lung tumor19
lymphoma13
non-neoplasia20
ovarian tumor13
pancreatic tumor152
primitive neuroectodermal tumor of the CNS7
prostate cancer115
skin tumor31
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult60
embryoid body28
blastocyst113
neonate64
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue129.4
adrenal gland72
appendix50
bone marrow47.5
cerebral cortex32.7
colon56.8
duodenum50.4
esophagus24.3
gallbladder22.7
heart muscle74.6
kidney91.3
liver72.2
lung58.9
lymph node35.9
ovary24.8
pancreas74.4
placenta47.9
prostate67.4
salivary gland88.5
skin35.9
small intestine54.2
spleen67.3
stomach65.8
testis38.7
thyroid gland26.5
urinary bladder28.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*601189, gene) Polymerase ii, rna, subunit l; POLR2LOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center