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> Protein (NX_P62937)
Protein (NX_P62937)
Protein
Gene SymbolPPIA to neXtProt (NX_P62937)
DescriptionPeptidyl-prolyl cis-trans isomerase A
Chromosome7
Location7p13 (44836279 ~ 44864163) to Ensembl
Sequene Features : Isoforms 2, Variants 12, PTMs 25 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of integrated proviral latency
.leukocyte migration
.positive regulation of protein secretion
  + 15 more...
.unfolded protein binding
.virion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.focal adhesion
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 12 25
2014-09-19protein level
1 8 24
2014-05-27protein level
1 8 24
2014-02-25protein level
1 8 23
2013-12-09protein level
1 6 23
2013-11-01protein level
1 6 21
2013-09-12protein level
1 6 22
2013-08-17protein level
1 6 22
2013-07-15protein level
1 5 14
2013-06-11protein level
1 5 14
2013-02-12protein level
1 1 16
2012-12-20protein level
1 2 16
2012-10-30protein level
1 2 16
2012-10-07protein level
1 2 16
2012-08-24protein level
1 2 16
2012-07-28protein level
1 2 16
2012-06-08protein level
1 7 16
2012-05-07protein level
1 7 16
2012-04-10protein level
1 7 16
2012-01-13protein level
1 16 16
2011-12-20protein level
1 16 16
2011-11-11protein level
1 16 15
2011-08-23protein level
1 16 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62937-1
2 4 1 18000.835
NX_P62937-2
1 4 0 11410.5185
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-437708,EBI-710464 SUPT5H  
  .negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.protein heterodimerization activity
.poly(A) RNA binding
.enzyme binding
.chromatin binding
.DSIF complex
.nucleoplasm
.nucleus
2 EBI-437708,EBI-728153 PTPRN  
  .dense core granule maturation
.response to cAMP
.response to estrogen
  + 6 more...
.spectrin binding
.phosphatase activity
.integral component of membrane
3 EBI-437708,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland1092
ascites1531
bladder1071
blood539
bone628
bone marrow697
brain609
cervix886
connective tissue147
ear993
embryonic tissue737
esophagus248
eye646
heart413
intestine819
kidney540
larynx298
liver1013
lung1015
lymph1783
lymph node679
mammary gland853
mouth438
muscle488
nerve386
ovary768
pancreas1011
parathyroid145
pharynx441
pituitary gland665
placenta427
prostate949
salivary gland1579
skin1309
spleen468
stomach972
testis434
thymus614
thyroid429
tonsil2056
trachea115
umbilical cord2470
uterus853
vascular464
Health State
TissuesTPM*
normal487
adrenal tumor1896
bladder carcinoma1762
breast (mammary gland) tumor794
cervical tumor1217
chondrosarcoma350
colorectal tumor1270
esophageal tumor289
gastrointestinal tumor1333
germ cell tumor1018
glioma727
head and neck tumor635
kidney tumor943
leukemia645
liver tumor1041
lung tumor2452
lymphoma1302
non-neoplasia289
ovarian tumor656
pancreatic tumor1190
primitive neuroectodermal tumor of the CNS1291
prostate cancer1463
retinoblastoma904
skin tumor1930
soft tissue/muscle tissue tumor806
uterine tumor987
Developmental Stage
TissuesTPM*
adult646
embryoid body686
blastocyst504
neonate1416
fetus353
infant850
juvenile1187
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue201.1
adrenal gland205.1
appendix274.1
bone marrow198.2
cerebral cortex190.3
colon321.8
duodenum219.7
esophagus285.9
gallbladder162.7
heart muscle118.4
kidney220.3
liver165.6
lung222.1
lymph node308.4
ovary143.9
pancreas74.4
placenta182.2
prostate172.3
salivary gland148.4
skin241.6
small intestine205.2
spleen201.5
stomach181.6
testis92.6
thyroid gland155.3
urinary bladder224.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123840, gene) Peptidyl-prolyl isomerase a; PPIAOMIM


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