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> Protein (NX_P62993)
Protein (NX_P62993)
Protein
Gene SymbolGRB2 to neXtProt (NX_P62993)
DescriptionGrowth factor receptor-bound protein 2
Chromosome17
Location17q25.1 (73314157 ~ 73401790) to Ensembl
Sequene Features : Isoforms 2, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 29 8
2014-09-19protein level
2 20 8
2014-05-27protein level
2 20 8
2014-02-25protein level
2 20 8
2013-12-09protein level
2 20 8
2013-11-01protein level
2 19 6
2013-09-12protein level
2 19 6
2013-08-17protein level
2 19 6
2013-07-15protein level
2 13 6
2013-06-11protein level
2 13 6
2013-02-12protein level
2 6 16
2012-12-20protein level
2 6 16
2012-10-30protein level
2 6 16
2012-10-07protein level
2 6 8
2012-08-24protein level
2 0 8
2012-07-28protein level
2 0 8
2012-06-08protein level
2 3 8
2012-05-07protein level
2 9 8
2012-04-10protein level
2 9 8
2012-01-13protein level
2 6 8
2011-12-20protein level
2 6 8
2011-11-11protein level
2 6 7
2011-08-23protein level
2 6 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P62993-1
4 7 0 25190.3636
NX_P62993-2
1 7 0 20543.9912
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-401755,EBI-957615 WASL  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of lymphocyte migration
.positive regulation of clathrin-mediated endocytosis
  + 24 more...
.GTPase regulator activity .extracellular exosome
.endocytic vesicle membrane
.actin cap
  + 6 more...
2 EBI-401755,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
3 EBI-401755,EBI-641107 PIK3C2B  
  .cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
4 EBI-401755,EBI-1753207 DLGAP1  
  .synaptic transmission .N/A .neuronal postsynaptic density
.postsynaptic membrane
.cell junction
5 EBI-401755,EBI-728180 PTPRT  
  .peptidyl-tyrosine dephosphorylation
.transmembrane receptor protein tyrosine kinase signaling pathway
.signal transduction
  + 3 more...
.delta-catenin binding
.cadherin binding
.gamma-catenin binding
  + 3 more...
.integral component of membrane
.cell surface
.plasma membrane
6 EBI-401755,EBI-1053996 PLD2  
  .regulation of phagocytosis
.inositol lipid-mediated signaling
.glycerophospholipid biosynthetic process
  + 12 more...
.N-acylphosphatidylethanolamine-specific phospholipase D activity
.phosphatidylinositol binding
.phospholipase D activity
.brush border membrane
.plasma membrane
.endoplasmic reticulum membrane
7 EBI-401755,EBI-310513 SYNJ2  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.phosphatidylinositol biosynthetic process
.phospholipid metabolic process
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.RNA binding
.nucleotide binding
.membrane
.cytosol
8 EBI-401755,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
9 EBI-401755,EBI-81570 FANCA  
  .regulation of cell proliferation
.female gonad development
.male gonad development
  + 3 more...
.N/A .Fanconi anaemia nuclear complex
.cytoplasm
.nucleolus
  + 2 more...
10 EBI-401755,EBI-310968 ASAP2  
  .positive regulation of catalytic activity .zinc ion binding
.enzyme activator activity
.GTPase activator activity
.Golgi cisterna membrane
.plasma membrane
11 EBI-401755,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
12 EBI-401755,EBI-1222766 LAT  
  .regulation of T cell activation
.T cell receptor signaling pathway
.positive regulation of protein kinase activity
  + 15 more...
.protein kinase binding
.SH3/SH2 adaptor activity
.membrane raft
.mast cell granule
.integral component of membrane
  + 4 more...
13 EBI-401755,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
14 EBI-401755,EBI-3914288 TSPAN2  
  .axon development
.oligodendrocyte differentiation
.myelination
  + 4 more...
.N/A .myelin sheath
.integral component of membrane
.plasma membrane
15 EBI-401755,EBI-723869 BRD4  
  .negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
16 EBI-401755,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
17 EBI-401755,EBI-712991 TOM1L1  
  .negative regulation of mitotic nuclear division
.ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.activation of protein kinase activity
  + 3 more...
.ubiquitin binding
.protein kinase activator activity
.clathrin binding
.protein kinase binding
.extracellular exosome
.endosome membrane
.cytosol
  + 4 more...
18 EBI-401755,EBI-396676 STAMBP  
  .negative regulation of Ras protein signal transduction
.negative regulation of neuron apoptotic process
.protein deubiquitination
  + 4 more...
.metal ion binding
.protein domain specific binding
.metallopeptidase activity
.ubiquitin-specific protease activity
.extracellular exosome
.cleavage furrow
.plasma membrane
  + 4 more...
19 EBI-401755,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
20 EBI-401755,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
21 EBI-401755,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
22 EBI-401755,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
23 EBI-401755,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
24 EBI-401755,EBI-712838 BCR  
  .regulation of cell cycle
.regulation of small GTPase mediated signal transduction
.neuromuscular process controlling balance
  + 15 more...
.kinase activity
.ATP binding
.GTPase activator activity
  + 3 more...
.extracellular exosome
.postsynaptic membrane
.protein complex
  + 4 more...
25 EBI-401755,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
26 EBI-401755,EBI-358730 DARS  
  .gene expression
.protein complex assembly
.aspartyl-tRNA aminoacylation
  + 2 more...
.poly(A) RNA binding
.ATP binding
.aspartate-tRNA ligase activity
.aminoacylase activity
.extracellular exosome
.membrane
.cytosol
.cytoplasm
27 EBI-401755,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
28 EBI-401755,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
29 EBI-401755,EBI-2609645 PTPRA  
  .peptidyl-tyrosine dephosphorylation
.insulin receptor signaling pathway
.axon guidance
.protein phosphorylation
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.receptor complex
.integral component of plasma membrane
.plasma membrane
30 EBI-401755,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
31 EBI-401755,EBI-350432 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
32 EBI-401755,EBI-1028658 FGFR2  
  .positive regulation of canonical Wnt signaling pathway
.positive regulation of ERK1 and ERK2 cascade
.regulation of ERK1 and ERK2 cascade
  + 104 more...
.protein homodimerization activity
.fibroblast growth factor binding
.heparin binding
  + 3 more...
.excitatory synapse
.intracellular membrane-bounded organelle
.cytoplasmic membrane-bounded vesicle
  + 11 more...
33 EBI-401755,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
34 EBI-401755,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
35 EBI-401755,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
36 EBI-401755,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
37 EBI-401755,EBI-78260 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
38 EBI-401755,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
39 EBI-401755,EBI-2850927 AXL  
  .negative regulation of dendritic cell apoptotic process
.dendritic cell differentiation
.cellular response to lipopolysaccharide
  + 33 more...
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.protein tyrosine kinase activity
.phosphatidylserine binding
.extracellular exosome
.host cell surface
.cell surface
  + 3 more...
40 EBI-401755,EBI-350338 MYH9  
  .positive regulation of protein processing in phagocytic vesicle
.negative regulation of actin filament severing
.platelet aggregation
  + 24 more...
.actin filament binding
.poly(A) RNA binding
.ADP binding
  + 9 more...
.myosin II filament
.extracellular exosome
.protein complex
  + 18 more...
41 EBI-401755,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
42 EBI-401755,EBI-518596 LEPR  
  .negative regulation of hydrolase activity
.negative regulation of gluconeogenesis
.cholesterol metabolic process
  + 3 more...
.identical protein binding
.cytokine receptor activity
.transmembrane signaling receptor activity
.receptor complex
.integral component of membrane
.plasma membrane
.extracellular region
43 EBI-401755,EBI-346547 DNM2  
  .negative regulation of membrane tubulation
.membrane organization
.regulation of nitric-oxide synthase activity
  + 16 more...
.enzyme binding
.SH3 domain binding
.microtubule binding
  + 2 more...
.extracellular exosome
.postsynaptic membrane
.endocytic vesicle membrane
  + 10 more...
44 EBI-401755,EBI-80252 EPHB1  
  .regulation of neuron death
.regulation of ERK1 and ERK2 cascade
.neural precursor cell proliferation
  + 17 more...
.axon guidance receptor activity
.ATP binding
.transmembrane-ephrin receptor activity
.extracellular exosome
.membrane raft
.early endosome membrane
  + 6 more...
45 EBI-401755,EBI-355164 VCP  
  .positive regulation of Lys63-specific deubiquitinase activity
.positive regulation of protein K63-linked deubiquitination
.error-free translesion synthesis
  + 22 more...
.ubiquitin-specific protease binding
.poly(A) RNA binding
.ADP binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 10 more...
46 EBI-401755,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
47 EBI-401755,EBI-1171238 DAB2  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of integrin-mediated signaling pathway
.positive regulation of early endosome to late endosome transport
  + 35 more...
.SMAD binding
.cargo receptor activity
.clathrin adaptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
  + 8 more...
48 EBI-401755,EBI-941975 ANK2  
  .positive regulation of cation channel activity
.positive regulation of calcium ion transmembrane transporter activity
.regulation of calcium ion transmembrane transporter activity
  + 40 more...
.ATPase binding
.ion channel binding
.protein binding, bridging
  + 5 more...
.perinuclear region of cytoplasm
.postsynaptic membrane
.membrane raft
  + 15 more...
49 EBI-401755,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
50 EBI-401755,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
51 EBI-401755,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
52 EBI-401755,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
53 EBI-401755,EBI-78615 PPARA  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of neuron death
.regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
  + 35 more...
.sequence-specific DNA binding
.ubiquitin conjugating enzyme binding
.lipid binding
  + 11 more...
.nucleoplasm
.nucleus
54 EBI-401755,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
55 EBI-401755,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
56 EBI-401755,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
57 EBI-401755,EBI-352922 PPP3CA  
  .positive regulation of cardiac muscle hypertrophy in response to stress
.cellular response to glucose stimulus
.regulation of excitatory postsynaptic membrane potential
  + 20 more...
.protein dimerization activity
.calmodulin-dependent protein phosphatase activity
.enzyme binding
  + 4 more...
.sarcolemma
.Z disc
.calcineurin complex
  + 4 more...
58 EBI-401755,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
59 EBI-401755,EBI-602199 ARHGEF5  
  .positive regulation of podosome assembly
.regulation of GTPase activity
.intracellular signal transduction
  + 2 more...
.GTP binding
.Rho guanyl-nucleotide exchange factor activity
.N/A
60 EBI-401755,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
61 EBI-401755,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
62 EBI-401755,EBI-307294 MAP2K5  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of chemokine (C-X-C motif) ligand 2 production
.negative regulation of cell migration involved in sprouting angiogenesis
  + 17 more...
.metal ion binding
.ATP binding
.protein tyrosine kinase activity
  + 3 more...
.cytosol
.spindle
.nucleus
.intracellular
63 EBI-401755,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
64 EBI-401755,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
65 EBI-401755,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
66 EBI-401755,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
67 EBI-401755,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
68 EBI-401755,EBI-446740 DOCK1  
  .vascular endothelial growth factor receptor signaling pathway
.innate immune response
.positive regulation of GTPase activity
  + 10 more...
.GTPase activator activity
.guanyl-nucleotide exchange factor activity
.membrane
.cytosol
.cytoplasm
  + 2 more...
69 EBI-401755,EBI-489954 FLNC  
  .muscle fiber development
.cell junction assembly
.ankyrin binding
.cytoskeletal protein binding
.costamere
.sarcolemma
.Z disc
  + 6 more...
70 EBI-401755,EBI-751746 ACAP1  
  .protein transport .zinc ion binding
.GTPase activator activity
.recycling endosome membrane
.membrane
71 EBI-401755,EBI-1646426 AGER  
  .positive regulation of NF-kappaB transcription factor activity
.induction of positive chemotaxis
.innate immune response
  + 4 more...
.S100 protein binding
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular region
72 EBI-401755,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
73 EBI-401755,EBI-351394 DBN1  
  .neural precursor cell proliferation
.regulation of dendrite development
.regulation of neuronal synaptic plasticity
  + 4 more...
.profilin binding
.actin binding
.actomyosin
.dendrite
.actin cytoskeleton
  + 4 more...
74 EBI-401755,EBI-743729 UGP2  
  .cellular glucuronidation
.small molecule metabolic process
.glucose 1-phosphate metabolic process
  + 6 more...
.metal ion binding
.identical protein binding
.pyrimidine ribonucleotide binding
  + 2 more...
.extracellular exosome
.cytosol
.nucleus
75 EBI-401755,EBI-10694905 TMEM128  
  .N/A .N/A .integral component of membrane
76 EBI-401755,EBI-10691507 PLEKHS1  
  .N/A .N/A .N/A
77 EBI-401755,EBI-5280499 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
78 EBI-401755,EBI-946029 C1orf94  
  .N/A .N/A .N/A
79 EBI-401755,EBI-710457 DPPA4  
  .lung-associated mesenchyme development
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
80 EBI-401755,EBI-1758170 MAP4K3  
  .regulation of apoptotic process
.intracellular signal transduction
.response to tumor necrosis factor
  + 6 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
81 EBI-401755,EBI-10172004 HOMEZ  
  .transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
82 EBI-401755,EBI-8029141 REPS2  
  .epidermal growth factor receptor signaling pathway
.protein complex assembly
.calcium ion binding .cytoplasm
83 EBI-401755,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
84 EBI-401755,EBI-10692065 LMX1A  
  .dopaminergic neuron differentiation
.negative regulation of neuron differentiation
.midbrain development
  + 7 more...
.sequence-specific DNA binding
.zinc ion binding
.nucleus
85 EBI-401755,EBI-2850112 WIPF2  
  .innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
.small GTPase mediated signal transduction
.N/A .cytoskeleton
.cytosol
86 EBI-401755,EBI-2623522 BLNK  
  .intracellular signal transduction
.B cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
.intracellular
87 EBI-401755,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
88 EBI-401755,EBI-3942425 SOCS4  
  .negative regulation of JAK-STAT cascade
.regulation of growth
.intracellular signal transduction
  + 4 more...
.protein kinase inhibitor activity .cytoplasm
89 EBI-401755,EBI-746012 DDX17  
  .regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
90 EBI-401755,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
91 EBI-401755,EBI-286693 TNPO1  
  .viral process
.gene expression
.organelle organization
.protein import into nucleus, translocation
.poly(A) RNA binding
.nuclear localization sequence binding
.primary cilium
.extracellular exosome
.cytosol
  + 2 more...
92 EBI-401755,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
93 EBI-401755,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
94 EBI-401755,EBI-750254 ARHGAP9  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.small GTPase mediated signal transduction
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.cytosol
95 EBI-401755,EBI-1752330 SHANK3  
  .positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.positive regulation of excitatory postsynaptic membrane potential
.regulation of long term synaptic depression
  + 25 more...
.scaffold protein binding
.identical protein binding
.ionotropic glutamate receptor binding
  + 4 more...
.neuronal postsynaptic density
.ciliary membrane
.postsynaptic membrane
  + 6 more...
96 EBI-401755,EBI-740897 NIF3L1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of transcription, DNA-templated
.neuron differentiation
.identical protein binding
.transcription factor binding
.mitochondrion
.cytoplasm
.nucleus
97 EBI-401755,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
98 EBI-401755,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
99 EBI-401755,EBI-3440103 GAREM  
  .cellular response to epidermal growth factor stimulus
.positive regulation of ERK1 and ERK2 cascade
.positive regulation of cell division
  + 2 more...
.proline-rich region binding .plasma membrane
100 EBI-401755,EBI-10693102 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
101 EBI-401755,EBI-1753397 DLGAP2  
  .neuron-neuron synaptic transmission .N/A .postsynaptic membrane
.cell junction
.postsynaptic density
.neurofilament
102 EBI-401755,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
103 EBI-401755,EBI-2941912 ERRFI1  
  .lung epithelium development
.lung vasculature development
.lung alveolus development
  + 6 more...
.protein kinase binding
.GTPase activator activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
104 EBI-401755,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
105 EBI-401755,EBI-297568 VAV3  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.B cell receptor signaling pathway
  + 22 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.GTPase activator activity
  + 2 more...
.extracellular exosome
.plasma membrane
.cytosol
106 EBI-401755,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
107 EBI-401755,EBI-1037322 TPX2  
  .regulation of mitotic spindle organization
.cell division
.activation of protein kinase activity
  + 3 more...
.protein kinase binding
.GTP binding
.ATP binding
.axon hillock
.microtubule cytoskeleton
.microtubule
  + 5 more...
108 EBI-401755,EBI-1570571 SHANK2  
  .vocalization behavior
.long term synaptic depression
.long-term synaptic potentiation
  + 6 more...
.ionotropic glutamate receptor binding
.GKAP/Homer scaffold activity
.ciliary membrane
.postsynaptic membrane
.dendritic spine
  + 12 more...
109 EBI-401755,EBI-975200 GAB2  
  .phosphatidylinositol-mediated signaling
.innate immune response
.positive regulation of mast cell degranulation
  + 6 more...
.phosphatidylinositol-3,4-bisphosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
110 EBI-401755,EBI-722139 DLGAP4  
  .signaling .N/A .synapse
.membrane
111 EBI-401755,EBI-1211241 PTPN22  
  .negative regulation of T cell activation
.negative regulation of T cell receptor signaling pathway
.regulation of B cell receptor signaling pathway
  + 7 more...
.kinase binding
.SH3 domain binding
.protein tyrosine phosphatase activity
.perinuclear region of cytoplasm
.cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
112 EBI-401755,EBI-714455 WBP11  
  .RNA splicing
.mRNA processing
.rRNA processing
.WW domain binding
.poly(A) RNA binding
.protein phosphatase type 1 regulator activity
.single-stranded DNA binding
.nuclear speck
.cytoplasm
.nucleoplasm
.nucleus
113 EBI-401755,EBI-719769 PRKAB1  
  .membrane organization
.protein heterooligomerization
.regulation of protein kinase activity
  + 10 more...
.AMP-activated protein kinase activity
.protein kinase activity
.AMP-activated protein kinase complex
.cytosol
.nucleus
114 EBI-401755,EBI-1279 MAP4K5  
  .regulation of apoptotic process
.intracellular signal transduction
.regulation of mitotic cell cycle
  + 3 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.plasma membrane
.cytoplasm
115 EBI-401755,EBI-298152 CD2AP  
  .regulation of actin cytoskeleton reorganization
.positive regulation of protein localization to nucleus
.cell division
  + 5 more...
.SH3 domain binding
.structural constituent of cytoskeleton
.extracellular exosome
.filamentous actin
.actin cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland151
ascites100
bladder66
blood188
bone125
bone marrow20
brain204
cervix61
connective tissue261
ear186
embryonic tissue140
esophagus99
eye134
heart201
intestine103
kidney118
larynx85
liver141
lung247
lymph135
lymph node323
mammary gland178
mouth151
muscle37
nerve128
ovary167
pancreas131
parathyroid242
pituitary gland60
placenta158
prostate116
salivary gland148
skin161
spleen318
stomach125
testis91
thymus250
thyroid64
tonsil293
trachea154
umbilical cord145
uterus124
vascular154
Health State
TissuesTPM*
normal169
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor204
cervical tumor86
chondrosarcoma217
colorectal tumor97
esophageal tumor115
gastrointestinal tumor101
germ cell tumor201
glioma307
head and neck tumor104
kidney tumor43
leukemia63
liver tumor166
lung tumor107
lymphoma152
non-neoplasia372
ovarian tumor196
pancreatic tumor104
primitive neuroectodermal tumor of the CNS149
prostate cancer125
retinoblastoma107
skin tumor207
soft tissue/muscle tissue tumor95
uterine tumor77
Developmental Stage
TissuesTPM*
adult146
embryoid body114
blastocyst146
neonate225
fetus172
infant297
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue49.7
adrenal gland49
appendix100.2
bone marrow94.4
cerebral cortex71.5
colon52
duodenum47.9
esophagus63.2
gallbladder56.8
heart muscle73.1
kidney43.8
liver23.6
lung56.7
lymph node132.5
ovary39.7
pancreas17.9
placenta69.5
prostate38.9
salivary gland30
skin26.4
small intestine53.5
spleen73.5
stomach43.2
testis24.4
thyroid gland52.4
urinary bladder96.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*108355, gene) Growth factor receptor-bound protein 2; GRB2OMIM


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