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> Protein (NX_P63000)
Protein (NX_P63000)
Protein
Gene SymbolRAC1 to neXtProt (NX_P63000)
DescriptionRas-related C3 botulinum toxin substrate 1
Chromosome7
Location7p22.1 (6414154 ~ 6443608) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 10
2014-09-19protein level
2 23 10
2014-05-27protein level
2 23 15
2014-02-25protein level
2 23 15
2013-12-09protein level
2 22 15
2013-11-01protein level
2 20 11
2013-09-12protein level
2 20 11
2013-08-17protein level
2 20 11
2013-07-15protein level
2 19 9
2013-06-11protein level
2 19 9
2013-02-12protein level
2 15 16
2012-12-20protein level
2 15 16
2012-10-30protein level
2 17 16
2012-10-07protein level
2 17 8
2012-08-24protein level
2 17 8
2012-07-28protein level
2 17 8
2012-06-08protein level
2 27 8
2012-05-07protein level
2 24 8
2012-04-10protein level
2 24 8
2012-01-13protein level
2 25 8
2011-12-20protein level
2 25 8
2011-11-11protein level
2 25 8
2011-08-23protein level
2 25 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63000-1
0 2 6 21436.1804
NX_P63000-2
2 2 5 23452.2385
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-413628,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
2 EBI-413628,EBI-3389553 PAK3  
  .positive regulation of DNA biosynthetic process
.positive regulation of dendritic spine morphogenesis
.dendritic spine morphogenesis
  + 21 more...
.Rac GTPase binding
.metal ion binding
.ATP binding
  + 2 more...
.plasma membrane
.cytosol
.endosome
.cytoplasm
3 EBI-413628,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
4 EBI-413628,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
5 EBI-413628,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
6 EBI-413628,EBI-712693 ARHGDIA  
  .semaphorin-plexin signaling pathway
.regulation of small GTPase mediated signal transduction
.positive regulation of axonogenesis
  + 10 more...
.GTPase activator activity
.Rho GDP-dissociation inhibitor activity
.extracellular exosome
.cytoskeleton
.cytosol
.immunological synapse
7 EBI-413628,EBI-714925 CHN2  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.positive regulation of signal transduction
.small GTPase mediated signal transduction
.metal ion binding
.GTPase activator activity
.SH3/SH2 adaptor activity
.membrane
.cytosol
8 EBI-413628,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
9 EBI-413628,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-413628,EBI-1053182 SET  
  .negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
11 EBI-413628,EBI-6148898 OCRL  
  .regulation of small GTPase mediated signal transduction
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 9 more...
.inositol phosphate phosphatase activity
.Rac GTPase binding
.GTPase activator activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.extracellular exosome
.early endosome membrane
.phagocytic vesicle membrane
  + 11 more...
12 EBI-413628,EBI-603614 CAV1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
13 EBI-413628,EBI-1307 PAK1  
  .negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
14 EBI-413628,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
15 EBI-413628,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
16 EBI-413628,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
17 EBI-413628,EBI-446740 DOCK1  
  .vascular endothelial growth factor receptor signaling pathway
.innate immune response
.positive regulation of GTPase activity
  + 10 more...
.GTPase activator activity
.guanyl-nucleotide exchange factor activity
.membrane
.cytosol
.cytoplasm
  + 2 more...
18 EBI-413628,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
19 EBI-413628,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
20 EBI-413628,EBI-9073209 TNFAIP8L2  
  .negative regulation of T cell activation
.negative regulation of inflammatory response
.innate immune response
.N/A .cytoplasm
21 EBI-413628,EBI-311339 SH3RF1  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of JNK cascade
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 2 more...
.ligase activity
.zinc ion binding
.perinuclear region of cytoplasm
.lamellipodium
.cytosol
.Golgi apparatus
22 EBI-413628,EBI-7975674 SH3RF3  
  .N/A .zinc ion binding .N/A
23 EBI-413628,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
24 EBI-413628,EBI-2825900 HMHA1  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.metal ion binding
.GTPase activator activity
.membrane
.cytosol
25 EBI-413628,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
26 EBI-413628,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
27 EBI-413628,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
28 EBI-413628,EBI-7797561 UNKL  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleus
29 EBI-413628,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
30 EBI-413628,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
31 EBI-413628,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
32 EBI-413628,EBI-954308 USH1C  
  .equilibrioception
.sensory perception of light stimulus
.photoreceptor cell maintenance
  + 5 more...
.spectrin binding .synapse
.apical part of cell
.stereocilium
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites677
bladder401
blood98
bone321
bone marrow143
brain151
cervix309
connective tissue93
ear807
embryonic tissue178
esophagus99
eye196
heart201
intestine469
kidney208
larynx383
liver180
lung268
lymph541
lymph node289
mammary gland528
mouth226
muscle197
nerve321
ovary266
pancreas599
parathyroid485
pharynx319
pituitary gland544
placenta211
prostate237
salivary gland246
skin365
spleen56
stomach376
testis66
thymus112
thyroid193
tonsil58
trachea57
umbilical cord217
uterus383
vascular96
Health State
TissuesTPM*
normal194
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor268
cervical tumor405
chondrosarcoma217
colorectal tumor728
esophageal tumor115
gastrointestinal tumor523
germ cell tumor148
glioma223
head and neck tumor306
kidney tumor188
leukemia169
liver tumor166
lung tumor330
lymphoma470
non-neoplasia113
ovarian tumor223
pancreatic tumor866
primitive neuroectodermal tumor of the CNS133
prostate cancer279
retinoblastoma172
skin tumor390
soft tissue/muscle tissue tumor199
uterine tumor499
Developmental Stage
TissuesTPM*
adult292
embryoid body200
blastocyst97
neonate96
fetus197
infant42
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue78.4
adrenal gland78.4
appendix69.8
bone marrow43
cerebral cortex115.9
colon119.9
duodenum110.7
esophagus155.7
gallbladder97.3
heart muscle73.2
kidney80.8
liver47.1
lung98.5
lymph node67.2
ovary92.5
pancreas30.9
placenta106.6
prostate81.1
salivary gland54.4
skin120.1
small intestine101.7
spleen66
stomach96.4
testis42.3
thyroid gland88.7
urinary bladder109.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602048, gene) Ras-related c3 botulinum toxin substrate 1; RAC1OMIM


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