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> Protein (NX_P63098)
Protein (NX_P63098)
Protein
Gene SymbolPPP3R1 to neXtProt (NX_P63098)
DescriptionCalcineurin subunit B type 1
Chromosome2
Location2p14 (68405989 ~ 68483369) to Ensembl
Sequene Features : Isoforms 1, Variants 15, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.positive regulation of NFAT protein import into nucleus
  + 8 more...
.protein domain specific binding
.calmodulin binding
.calcium ion binding
.calcium-dependent protein serine/threonine phosphatase activity
.sarcolemma
.calcineurin complex
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 15 3
2014-09-19protein level
1 13 3
2014-05-27protein level
1 13 4
2014-02-25protein level
1 13 4
2013-12-09protein level
1 12 4
2013-11-01protein level
1 12 4
2013-09-12protein level
1 12 4
2013-08-17protein level
1 12 4
2013-07-15protein level
1 8 2
2013-06-11protein level
1 8 2
2013-02-12protein level
1 2 2
2012-12-20protein level
1 2 2
2012-10-30protein level
1 2 2
2012-10-07protein level
1 2 2
2012-08-24protein level
1 1 2
2012-07-28protein level
1 1 2
2012-06-08protein level
1 1 2
2012-05-07protein level
1 1 2
2012-04-10protein level
1 1 2
2012-01-13protein level
1 2 2
2011-12-20protein level
1 2 2
2011-11-11protein level
1 2 2
2011-08-23protein level
1 2 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63098-1
7 0 1 19287.5217
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-915984,EBI-352922 PPP3CA  
  .positive regulation of cardiac muscle hypertrophy in response to stress
.cellular response to glucose stimulus
.regulation of excitatory postsynaptic membrane potential
  + 20 more...
.protein dimerization activity
.calmodulin-dependent protein phosphatase activity
.enzyme binding
  + 4 more...
.sarcolemma
.Z disc
.calcineurin complex
  + 4 more...
2 EBI-915984,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone13
brain16
embryonic tissue9
eye14
intestine12
kidney4
liver4
lung5
lymph node33
mammary gland19
mouth15
muscle18
nerve64
ovary19
pancreas4
placenta24
prostate10
skin14
spleen18
stomach94
testis11
uterus12
vascular38
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor10
colorectal tumor17
gastrointestinal tumor59
germ cell tumor15
glioma9
leukemia42
lymphoma27
non-neoplasia10
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
skin tumor7
Developmental Stage
TissuesTPM*
adult21
blastocyst16
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.7
adrenal gland37.4
appendix33.2
bone marrow37.8
cerebral cortex104
colon26
duodenum23.4
esophagus30.6
gallbladder30.1
heart muscle15.9
kidney18.8
liver29.7
lung24.8
lymph node38.3
ovary24.4
pancreas8.9
placenta30.1
prostate24.2
salivary gland16.8
skin28.5
small intestine21.9
spleen28.6
stomach24.8
testis22.5
thyroid gland24.5
urinary bladder31.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonLow
duodenumLow
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyLow
lateral ventricleHigh
lymph nodeMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
rectumLow
salivary glandMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
tonsilLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601302, gene) Protein phosphatase 3, regulatory subunit b, alpha; PPP3R1OMIM


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