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> Protein (NX_P63165)
Protein (NX_P63165)
Protein
Gene SymbolSUMO1 to neXtProt (NX_P63165)
DescriptionSmall ubiquitin-related modifier 1
Chromosome2
Location2q33.1 (203070903 ~ 203103331) to Ensembl
Sequene Features : Isoforms 2, Variants 6, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 6 13
2014-09-19protein level
2 3 13
2014-05-27protein level
2 3 13
2014-02-25protein level
2 3 13
2013-12-09protein level
2 3 13
2013-11-01protein level
2 3 13
2013-09-12protein level
2 3 13
2013-08-17protein level
2 3 13
2013-07-15protein level
1 4 11
2013-06-11protein level
1 4 11
2013-02-12protein level
1 0 10
2012-12-20protein level
1 0 10
2012-10-30protein level
1 0 10
2012-10-07protein level
1 0 10
2012-08-24protein level
1 0 10
2012-07-28protein level
1 0 10
2012-06-08protein level
1 2 10
2012-05-07protein level
1 5 10
2012-04-10protein level
1 5 10
2012-01-13protein level
1 2 10
2011-12-20protein level
1 2 10
2011-11-11protein level
1 2 8
2011-08-23protein level
1 2 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63165-1
2 3 0 11549.673
NX_P63165-2
1 3 0 8793.2213
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-80140,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-80140,EBI-607761 SART1  
  .intrinsic apoptotic signaling pathway
.positive regulation of cytotoxic T cell differentiation
.mRNA cis splicing, via spliceosome
  + 4 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U4/U6 x U5 tri-snRNP complex
.Cajal body
  + 4 more...
3 EBI-80140,EBI-1801773 PSIP1  
  .establishment of integrated proviral latency
.positive regulation of transcription from RNA polymerase II promoter
.viral process
  + 5 more...
.supercoiled DNA binding
.poly(A) RNA binding
.activating transcription factor binding
  + 2 more...
.transcriptionally active chromatin
.nuclear periphery
.cytosol
  + 3 more...
4 EBI-80140,EBI-7839538 PRDM1  
  .trophoblast giant cell differentiation
.intestinal epithelial cell development
.positive regulation of B cell differentiation
  + 9 more...
.metal ion binding
.methyltransferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.cytoplasm
.nucleus
5 EBI-80140,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
6 EBI-80140,EBI-1059030 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
7 EBI-80140,EBI-73440 EIF4E  
  .positive regulation of mitotic cell cycle
.cellular protein metabolic process
.lung development
  + 11 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA cap binding
.extracellular exosome
.chromatoid body
.RISC complex
  + 6 more...
8 EBI-80140,EBI-357966 HNRNPC  
  .3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
9 EBI-80140,EBI-355676 PARP1  
  .positive regulation of transcription regulatory region DNA binding
.cellular response to superoxide
.protein poly-ADP-ribosylation
  + 22 more...
.NAD binding
.protein N-terminus binding
.poly(A) RNA binding
  + 7 more...
.membrane
.nucleolus
.transcription factor complex
  + 3 more...
10 EBI-80140,EBI-298355 MYB  
  .cellular response to interleukin-6
.positive regulation of histone H3-K9 methylation
.positive regulation of histone H3-K4 methylation
  + 15 more...
.chromatin binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nuclear matrix
.cytosol
11 EBI-80140,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
12 EBI-80140,EBI-413374 RARA  
  .cellular response to estrogen stimulus
.cellular response to retinoic acid
.cellular response to lipopolysaccharide
  + 54 more...
.alpha-actinin binding
.protein kinase A binding
.mRNA 5'-UTR binding
  + 19 more...
.perinuclear region of cytoplasm
.neuronal cell body
.dendrite
  + 6 more...
13 EBI-80140,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
14 EBI-80140,EBI-726632 ELK1  
  .positive regulation of neuron death
.cellular response to gamma radiation
.cellular response to testosterone stimulus
  + 20 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.chromatin binding
  + 4 more...
.axon terminus
.neuronal cell body
.dendrite
  + 3 more...
15 EBI-80140,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
16 EBI-80140,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
17 EBI-80140,EBI-396091 RANGAP1  
  .negative regulation of protein export from nucleus
.positive regulation of GTPase activity
.small GTPase mediated signal transduction
  + 2 more...
.GTPase activator activity .perinuclear region of cytoplasm
.nuclear membrane
.cytosol
  + 4 more...
18 EBI-80140,EBI-6124081 SOX2  
  .neuronal stem cell maintenance
.negative regulation of canonical Wnt signaling pathway
.response to growth factor
  + 44 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.miRNA binding
  + 5 more...
.nuclear transcription factor complex
.cytosol
.cytoplasm
  + 3 more...
19 EBI-80140,EBI-1167533 SOX10  
  .negative regulation of canonical Wnt signaling pathway
.oligodendrocyte differentiation
.developmental growth
  + 13 more...
.identical protein binding
.transcription coactivator activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 4 more...
.extrinsic component of mitochondrial outer membrane
.nucleus
20 EBI-80140,EBI-80168 UBE2I  
  .positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
21 EBI-80140,EBI-307326 NFKB2  
  .positive regulation of NF-kappaB transcription factor activity
.spleen development
.rhythmic process
  + 25 more...
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.Bcl3/NF-kappaB2 complex
.cytosol
.cytoplasm
  + 2 more...
22 EBI-80140,EBI-743747 SATB1  
  .reflex
.activated T cell proliferation
.CD8-positive, alpha-beta T cell differentiation
  + 10 more...
.double-stranded DNA binding
.chromatin binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.PML body
.nuclear matrix
.nuclear heterochromatin
  + 2 more...
23 EBI-80140,EBI-748597 CCDC67  
  .multi-ciliated epithelial cell differentiation
.de novo centriole assembly
.cell projection organization
.N/A .deuterosome
.cytoplasm
24 EBI-80140,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
25 EBI-80140,EBI-7227791 ZBTB6  
  .negative regulation of transcription from RNA polymerase II promoter .metal ion binding
.DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
26 EBI-80140,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
27 EBI-80140,EBI-2513899 USPL1  
  .Cajal body organization
.protein desumoylation
.cell proliferation
.SUMO-specific isopeptidase activity
.SUMO binding
.Cajal body
.extracellular space
28 EBI-80140,EBI-748373 ZCCHC12  
  .BMP signaling pathway
.transcription, DNA-templated
.ligand-dependent nuclear receptor transcription coactivator activity
.zinc ion binding
.nucleic acid binding
.nuclear speck
29 EBI-80140,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
30 EBI-80140,EBI-741424 MAPK1IP1L  
  .N/A .N/A .N/A
31 EBI-80140,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
32 EBI-80140,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
33 EBI-80140,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
34 EBI-80140,EBI-726822 FAM118B  
  .N/A .N/A .Cajal body
35 EBI-80140,EBI-372094 RHOXF2  
  .regulation of transcription, DNA-templated .sequence-specific DNA binding .nucleus
36 EBI-80140,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
37 EBI-80140,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
38 EBI-80140,EBI-3918996 ZBTB26  
  .negative regulation of transcription from RNA polymerase II promoter .metal ion binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
39 EBI-80140,EBI-2822935 SENP1  
  .apoptotic signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
  + 7 more...
.SUMO-specific protease activity
.endopeptidase activity
.nuclear membrane
.focal adhesion
.cytoplasm
  + 2 more...
40 EBI-80140,EBI-80125 DNMT3B  
  .cellular response to amino acid stimulus
.negative regulation of histone H3-K9 methylation
.positive regulation of histone H3-K4 methylation
  + 16 more...
.DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
.metal ion binding
.unmethylated CpG binding
  + 3 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nuclear heterochromatin
  + 2 more...
41 EBI-80140,EBI-718569 UBA2  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of catalytic activity
.protein sumoylation
.protein heterodimerization activity
.metal ion binding
.SUMO activating enzyme activity
  + 2 more...
.SUMO activating enzyme complex
.cytosol
.nucleoplasm
.nucleus
42 EBI-80140,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
43 EBI-80140,EBI-867196 MBD1  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.methyl-CpG binding
.zinc ion binding
.transcription corepressor activity
  + 2 more...
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
44 EBI-80140,EBI-7228860 ZMYM5  
  .N/A .zinc ion binding .nucleus
45 EBI-80140,EBI-1549885 RWDD3  
  .positive regulation of hypoxia-inducible factor-1alpha signaling pathway
.positive regulation of protein sumoylation
.negative regulation of NF-kappaB transcription factor activity
.N/A .cytoplasm
.nucleus
46 EBI-80140,EBI-948156 RAD54L2  
  .N/A .ATP binding
.helicase activity
.transcription cofactor activity
.DNA binding
.nucleus
47 EBI-80140,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland242
ascites100
bladder234
blood106
bone97
bone marrow287
brain90
cervix103
connective tissue33
embryonic tissue112
eye52
heart44
intestine77
kidney123
larynx42
liver107
lung140
lymph node66
mammary gland52
mouth30
muscle75
nerve257
ovary49
pancreas74
parathyroid534
pharynx98
pituitary gland60
placenta77
prostate100
salivary gland493
skin85
spleen37
stomach94
testis119
thyroid21
tonsil58
uterus77
vascular77
Health State
TissuesTPM*
normal81
adrenal tumor237
bladder carcinoma398
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma36
colorectal tumor71
gastrointestinal tumor92
germ cell tumor170
glioma261
head and neck tumor14
kidney tumor203
leukemia169
liver tumor145
lung tumor68
lymphoma110
non-neoplasia10
ovarian tumor78
pancreatic tumor47
primitive neuroectodermal tumor of the CNS86
prostate cancer134
retinoblastoma129
skin tumor71
soft tissue/muscle tissue tumor79
uterine tumor66
Developmental Stage
TissuesTPM*
adult77
embryoid body85
blastocyst97
fetus57
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue41.7
adrenal gland62.7
appendix40.7
bone marrow51.7
cerebral cortex44.3
colon52.2
duodenum39.8
esophagus40.1
gallbladder44.5
heart muscle38.9
kidney60.6
liver54.8
lung40
lymph node50.3
ovary33.5
pancreas16
placenta43.3
prostate48.5
salivary gland32.3
skin30.4
small intestine49.2
spleen41.2
stomach42.4
testis34.9
thyroid gland58.4
urinary bladder49.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601912, gene) Small ubiquitin-like modifier 1; SUMO1OMIM
2(#613705, phenotype) Orofacial cleft 10; OFC10OMIM


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