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> Protein (NX_P63208)
Protein (NX_P63208)
Protein
Gene SymbolSKP1 to neXtProt (NX_P63208)
DescriptionS-phase kinase-associated protein 1
Chromosome5
Location5q31.1 (133484633 ~ 133512729) to Ensembl
Sequene Features : Isoforms 2, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 12 6
2014-09-19protein level
2 10 6
2014-05-27protein level
2 10 6
2014-02-25protein level
2 10 6
2013-12-09protein level
2 10 6
2013-11-01protein level
2 10 6
2013-09-12protein level
2 10 6
2013-08-17protein level
2 10 6
2013-07-15protein level
2 7 2
2013-06-11protein level
2 7 2
2013-02-12protein level
2 4 3
2012-12-20protein level
2 4 3
2012-10-30protein level
2 5 3
2012-10-07protein level
2 5 2
2012-08-24protein level
2 3 2
2012-07-28protein level
2 3 2
2012-06-08protein level
2 3 2
2012-05-07protein level
2 3 2
2012-04-10protein level
2 3 2
2012-01-13protein level
2 3 2
2011-12-20protein level
2 3 2
2011-11-11protein level
2 3 2
2011-08-23protein level
2 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63208-1
2 7 0 18646.1929
NX_P63208-2
1 7 0 18051.9073
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307486,EBI-2557598 ECD  
  .regulation of G1/S transition of mitotic cell cycle
.cell proliferation
.transcription from RNA polymerase II promoter
  + 2 more...
.transcription coactivator activity .cytoplasm
.nucleoplasm
2 EBI-307486,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
3 EBI-307486,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
4 EBI-307486,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
5 EBI-307486,EBI-1207574 CCNF  
  .cell division
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.protein ubiquitination
  + 4 more...
.N/A .SCF ubiquitin ligase complex
.centriole
.nucleus
6 EBI-307486,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
7 EBI-307486,EBI-456291 SKP2  
  .cellular response to cell-matrix adhesion
.regulation of cell cycle
.positive regulation of smooth muscle cell proliferation
  + 8 more...
.identical protein binding
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.aggresome
.cytosol
  + 4 more...
8 EBI-307486,EBI-359390 CUL1  
  .intrinsic apoptotic signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 17 more...
.N/A .Parkin-FBXW7-Cul1 ubiquitin ligase complex
.cullin-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
9 EBI-307486,EBI-2322729 FBXW9  
  .SCF-dependent proteasomal ubiquitin-dependent protein catabolic process .N/A .N/A
10 EBI-307486,EBI-2322982 FBXO46  
  .N/A .N/A .N/A
11 EBI-307486,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
12 EBI-307486,EBI-1047804 FBXO11  
  .peptidyl-arginine N-methylation
.protein ubiquitination
.sensory perception of sound
  + 2 more...
.protein-arginine N-methyltransferase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleolus
.chromosome
  + 2 more...
13 EBI-307486,EBI-2851213 TTC9C  
  .N/A .N/A .N/A
14 EBI-307486,EBI-359574 FBXW7  
  .negative regulation of SREBP signaling pathway
.negative regulation of hepatocyte proliferation
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 24 more...
.ubiquitin-protein transferase activator activity
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.protein complex
.SCF ubiquitin ligase complex
  + 5 more...
15 EBI-307486,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
16 EBI-307486,EBI-2321097 FBXL8  
  .N/A .N/A .N/A
17 EBI-307486,EBI-2510157 FBXO17  
  .N/A .glycoprotein binding .SCF ubiquitin ligase complex
18 EBI-307486,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
19 EBI-307486,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
20 EBI-307486,EBI-2322644 FBXO44  
  .N/A .N/A .SCF ubiquitin ligase complex
21 EBI-307486,EBI-740282 FBXO28  
  .N/A .N/A .N/A
22 EBI-307486,EBI-4287196 FBXO2  
  .regulation of protein ubiquitination
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.ER-associated ubiquitin-dependent protein catabolic process
  + 5 more...
.carbohydrate binding
.ubiquitin-protein transferase activity
.beta-amyloid binding
.extracellular exosome
.dendritic spine
.organelle membrane
  + 3 more...
23 EBI-307486,EBI-2509901 FBXO3  
  .proteolysis .ubiquitin-protein transferase activity .cytoplasm
.nucleoplasm
24 EBI-307486,EBI-2692340 FBXL5  
  .positive regulation of cellular protein catabolic process
.iron ion homeostasis
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
.protein ubiquitination
.iron ion binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.SCF ubiquitin ligase complex
.ubiquitin ligase complex
25 EBI-307486,EBI-355189 FBXW11  
  .rhythmic process
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 14 more...
.ubiquitin-protein transferase activity .SCF ubiquitin ligase complex
.cytosol
.centrosome
  + 2 more...
26 EBI-307486,EBI-914727 FBXW2  
  .protein ubiquitination
.proteolysis
.cellular protein modification process
.ubiquitin-protein transferase activity .cytoplasm
27 EBI-307486,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
28 EBI-307486,EBI-1161222 FBXO7  
  .negative regulation of G1/S transition of mitotic cell cycle
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of lymphocyte differentiation
  + 5 more...
.ubiquitin-protein transferase activity .protein complex
.cytosol
.mitochondrion
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland425
ascites25
bladder703
blood515
bone265
bone marrow533
brain226
cervix123
connective tissue1334
ear248
embryonic tissue206
esophagus99
eye172
heart256
intestine116
kidney232
liver418
lung226
lymph67
lymph node100
mammary gland152
mouth75
muscle573
nerve257
ovary108
pancreas360
parathyroid534
pharynx2013
pituitary gland544
placenta190
prostate274
salivary gland690
skin194
spleen56
stomach73
testis369
thymus112
thyroid64
tonsil176
umbilical cord72
uterus185
vascular425
Health State
TissuesTPM*
normal268
adrenal tumor474
bladder carcinoma1308
breast (mammary gland) tumor96
cervical tumor144
chondrosarcoma265
colorectal tumor44
esophageal tumor115
gastrointestinal tumor33
germ cell tumor235
glioma223
head and neck tumor97
kidney tumor232
leukemia317
liver tumor312
lung tumor145
lymphoma96
non-neoplasia93
ovarian tumor78
pancreatic tumor352
primitive neuroectodermal tumor of the CNS125
prostate cancer211
retinoblastoma129
skin tumor255
soft tissue/muscle tissue tumor1580
uterine tumor266
Developmental Stage
TissuesTPM*
adult251
embryoid body114
blastocyst260
neonate32
fetus183
infant212
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue174.6
adrenal gland271.6
appendix129.4
bone marrow133.6
cerebral cortex285.2
colon188.2
duodenum144.9
esophagus202.5
gallbladder209.6
heart muscle297.1
kidney251.8
liver129.6
lung145.8
lymph node162.4
ovary261.3
pancreas68.1
placenta200.9
prostate217.6
salivary gland130.9
skin128.8
small intestine157.2
spleen127.8
stomach133.5
testis214.3
thyroid gland281
urinary bladder241.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601434, gene) S-phase kinase-associated protein 1a; SKP1AOMIM


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