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> Protein (NX_P63218)
Protein (NX_P63218)
Protein
Gene SymbolGNG5 to neXtProt (NX_P63218)
DescriptionGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Chromosome1
Location1p22.3 (84964008 ~ 84972248) to Ensembl
Sequene Features : Isoforms 1, Variants 10, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.PDZ domain binding
.signal transducer activity
.GTPase activity
.extracellular exosome
.membrane
.plasma membrane
.heterotrimeric G-protein complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 10 8
2014-09-19protein level
1 8 8
2014-05-27protein level
1 8 8
2014-02-25protein level
1 7 8
2013-12-09protein level
1 5 8
2013-11-01protein level
1 5 7
2013-09-12protein level
1 5 7
2013-08-17protein level
1 5 7
2013-07-15protein level
1 4 5
2013-06-11protein level
1 4 5
2013-02-12protein level
1 1 5
2012-12-20protein level
1 1 5
2012-10-30protein level
1 2 5
2012-10-07protein level
1 2 5
2012-08-24protein level
1 1 5
2012-07-28protein level
1 1 5
2012-06-08protein level
1 1 5
2012-05-07protein level
1 1 5
2012-04-10protein level
1 1 5
2012-01-13protein level
1 2 5
2011-12-20protein level
1 2 5
2011-11-11protein level
1 2 4
2011-08-23protein level
1 2 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63218-1
3 0 0 7313.7836
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10220734,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
2 EBI-10220734,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
3 EBI-10220734,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-10220734,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
5 EBI-10220734,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
6 EBI-10220734,EBI-2556746 EPS15L1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.epidermal growth factor receptor signaling pathway
.endocytosis
.calcium ion binding .clathrin coat of coated pit
.membrane
.plasma membrane
.nucleus
7 EBI-10220734,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites25
blood16
bone27
bone marrow82
brain19
connective tissue46
ear186
embryonic tissue37
eye62
heart134
intestine77
kidney33
liver38
lung41
lymph22
lymph node22
mammary gland33
mouth45
muscle9
ovary19
pancreas28
pituitary gland121
placenta7
prostate31
skin104
spleen74
stomach52
testis34
thyroid42
tonsil117
trachea19
umbilical cord145
uterus64
vascular19
Health State
TissuesTPM*
normal41
adrenal tumor79
chondrosarcoma24
colorectal tumor71
gastrointestinal tumor33
glioma83
head and neck tumor37
kidney tumor43
leukemia52
liver tumor62
lung tumor38
lymphoma41
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer57
skin tumor119
soft tissue/muscle tissue tumor79
uterine tumor66
Developmental Stage
TissuesTPM*
adult36
embryoid body71
blastocyst32
neonate64
fetus53
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.3
adrenal gland36.7
appendix55.5
bone marrow73.6
cerebral cortex14.9
colon79.6
duodenum65.2
esophagus44.4
gallbladder44.1
heart muscle97.5
kidney50.9
liver49.4
lung59.7
lymph node52.3
ovary32.2
pancreas28.9
placenta54.3
prostate46.7
salivary gland56.7
skin41.7
small intestine64.5
spleen57
stomach63.8
testis45.9
thyroid gland46
urinary bladder50.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600874, gene) Guanine nucleotide-binding protein, gamma-5; GNG5OMIM


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