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> Protein (NX_P63279)
Protein (NX_P63279)
Protein
Gene SymbolUBE2I to neXtProt (NX_P63279)
DescriptionSUMO-conjugating enzyme UBC9
Chromosome16
Location16p13.3 (1355548 ~ 1377019) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of SUMO transferase activity
.cell division
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 14 more...
.RING-like zinc finger domain binding
.SUMO conjugating enzyme activity
.poly(A) RNA binding
  + 6 more...
.sumoylated E2 ligase complex
.transferase complex
.synapse
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 6
2014-09-19protein level
1 10 6
2014-05-27protein level
1 10 6
2014-02-25protein level
1 10 6
2013-12-09protein level
1 10 6
2013-11-01protein level
1 9 4
2013-09-12protein level
1 9 4
2013-08-17protein level
1 9 4
2013-07-15protein level
1 6 2
2013-06-11protein level
1 6 2
2013-02-12protein level
1 2 2
2012-12-20protein level
1 1 2
2012-10-30protein level
1 1 2
2012-10-07protein level
1 1 2
2012-08-24protein level
1 1 2
2012-07-28protein level
1 1 2
2012-06-08protein level
1 20 2
2012-05-07protein level
1 20 2
2012-04-10protein level
1 20 2
2012-01-13protein level
1 21 2
2011-12-20protein level
1 21 2
2011-11-11protein level
1 21 2
2011-08-23protein level
1 21 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P63279-1
8 0 0 17995.1479
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-80168,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-80168,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
3 EBI-80168,EBI-747310 IPO13  
  .protein import into nucleus .N/A .cytoplasm
.nucleus
4 EBI-80168,EBI-347351 TFAP2A  
  .negative regulation of reactive oxygen species metabolic process
.metanephric nephron development
.basement membrane organization
  + 43 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 14 more...
.intracellular membrane-bounded organelle
.centrosome
.Golgi apparatus
  + 3 more...
5 EBI-80168,EBI-726632 ELK1  
  .positive regulation of neuron death
.cellular response to gamma radiation
.cellular response to testosterone stimulus
  + 20 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.chromatin binding
  + 4 more...
.axon terminus
.neuronal cell body
.dendrite
  + 3 more...
6 EBI-80168,EBI-709688 UBA1  
  .modification-dependent protein catabolic process
.protein ubiquitination
.cellular response to DNA damage stimulus
.poly(A) RNA binding
.ATP binding
.ubiquitin-protein transferase activity
.ubiquitin activating enzyme activity
.extracellular exosome
.cytosol
.mitochondrion
  + 2 more...
7 EBI-80168,EBI-396091 RANGAP1  
  .negative regulation of protein export from nucleus
.positive regulation of GTPase activity
.small GTPase mediated signal transduction
  + 2 more...
.GTPase activator activity .perinuclear region of cytoplasm
.nuclear membrane
.cytosol
  + 4 more...
8 EBI-80168,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
9 EBI-80168,EBI-1167533 SOX10  
  .negative regulation of canonical Wnt signaling pathway
.oligodendrocyte differentiation
.developmental growth
  + 13 more...
.identical protein binding
.transcription coactivator activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 4 more...
.extrinsic component of mitochondrial outer membrane
.nucleus
10 EBI-80168,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
11 EBI-80168,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
12 EBI-80168,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-80168,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
14 EBI-80168,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
15 EBI-80168,EBI-1220123 SETX  
  .positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
.positive regulation of DNA-templated transcription, initiation
.cellular response to retinoic acid
  + 20 more...
.identical protein binding
.ATP binding
.DNA helicase activity
  + 2 more...
.growth cone
.axon
.cytoplasm
  + 5 more...
16 EBI-80168,EBI-7265024 ZCCHC7  
  .N/A .poly(A) RNA binding
.zinc ion binding
.cytoplasm
.nucleolus
.nucleus
17 EBI-80168,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
18 EBI-80168,EBI-937309 TFAP2C  
  .epithelial cell proliferation involved in mammary gland duct elongation
.dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
.sebaceous gland development
  + 15 more...
.protein dimerization activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 5 more...
.nucleus
19 EBI-80168,EBI-3918996 ZBTB26  
  .negative regulation of transcription from RNA polymerase II promoter .metal ion binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
20 EBI-80168,EBI-80125 DNMT3B  
  .cellular response to amino acid stimulus
.negative regulation of histone H3-K9 methylation
.positive regulation of histone H3-K4 methylation
  + 16 more...
.DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
.metal ion binding
.unmethylated CpG binding
  + 3 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nuclear heterochromatin
  + 2 more...
21 EBI-80168,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
22 EBI-80168,EBI-1549885 RWDD3  
  .positive regulation of hypoxia-inducible factor-1alpha signaling pathway
.positive regulation of protein sumoylation
.negative regulation of NF-kappaB transcription factor activity
.N/A .cytoplasm
.nucleus
23 EBI-80168,EBI-747230 ZNF451  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland60
ascites125
bladder66
blood65
bone55
bone marrow82
brain67
cervix103
connective tissue53
ear124
embryonic tissue89
esophagus49
eye67
heart201
intestine193
kidney109
larynx42
liver58
lung128
lymph22
lymph node356
mammary gland66
mouth15
muscle75
nerve128
ovary315
pancreas192
parathyroid291
pharynx24
pituitary gland60
placenta88
prostate131
skin137
spleen93
stomach564
testis87
thymus37
thyroid558
tonsil58
trachea19
umbilical cord145
uterus94
vascular77
Health State
TissuesTPM*
normal101
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma108
colorectal tumor177
esophageal tumor57
gastrointestinal tumor497
germ cell tumor94
glioma139
head and neck tumor22
kidney tumor130
leukemia169
liver tumor41
lung tumor116
lymphoma69
non-neoplasia72
ovarian tumor354
pancreatic tumor199
primitive neuroectodermal tumor of the CNS102
prostate cancer134
retinoblastoma21
skin tumor135
soft tissue/muscle tissue tumor119
uterine tumor122
Developmental Stage
TissuesTPM*
adult117
embryoid body85
blastocyst97
neonate64
fetus109
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.7
adrenal gland59.6
appendix67.4
bone marrow79
cerebral cortex39.6
colon50.3
duodenum43.1
esophagus43.7
gallbladder44.6
heart muscle45.8
kidney33.7
liver20.6
lung50.1
lymph node77.5
ovary88.5
pancreas22.2
placenta59.3
prostate50.7
salivary gland36.3
skin47.2
small intestine46.7
spleen71.8
stomach47.6
testis54.6
thyroid gland46
urinary bladder53.7
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastLow
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleLow
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasLow
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 1Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601661, gene) Ubiquitin-conjugating enzyme e2i; UBE2IOMIM


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