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> Protein (NX_P68106)
Protein (NX_P68106)
Protein
Gene SymbolFKBP1B to neXtProt (NX_P68106)
DescriptionPeptidyl-prolyl cis-trans isomerase FKBP1B
Chromosome2
Location2p23.3 (24272571 ~ 24286551) to Ensembl
Sequene Features : Isoforms 2, Variants 5, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 5 0
2014-09-19protein level
2 4 0
2014-05-27protein level
2 4 0
2014-02-25protein level
2 4 0
2013-12-09protein level
2 4 0
2013-11-01protein level
2 3 0
2013-09-12protein level
2 3 0
2013-08-17protein level
2 3 0
2013-07-15protein level
2 2 0
2013-06-11protein level
2 2 0
2013-02-12protein level
2 0 0
2012-12-20protein level
2 0 0
2012-10-30protein level
2 0 0
2012-10-07protein level
2 0 0
2012-08-24protein level
2 0 0
2012-07-28protein level
2 0 0
2012-06-08protein level
2 0 0
2012-05-07protein level
2 2 0
2012-04-10protein level
2 2 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 0 0
2011-11-11protein level
2 0 0
2011-08-23protein level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P68106-1
2 2 0 11774.9817
NX_P68106-2
1 2 0 8796.4553
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6693977,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
2 EBI-6693977,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
3 EBI-6693977,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-6693977,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
5 EBI-6693977,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
6 EBI-6693977,EBI-749955 TRIM69  
  .apoptotic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nuclear speck
.plasma membrane
.cytoplasm
.nucleus
7 EBI-6693977,EBI-1170425 RYR2  
  .positive regulation of calcium-transporting ATPase activity
.regulation of ventricular cardiac muscle cell action potential
.regulation of atrial cardiac muscle cell action potential
  + 40 more...
.calcium-induced calcium release activity
.ion channel binding
.suramin binding
  + 10 more...
.extracellular exosome
.protein complex
.calcium channel complex
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood8
brain24
connective tissue20
embryonic tissue14
eye23
intestine4
kidney9
liver4
lung11
muscle18
nerve64
placenta3
skin4
testis2
uterus25
Health State
TissuesTPM*
normal15
adrenal tumor79
chondrosarcoma12
germ cell tumor15
glioma9
non-neoplasia20
primitive neuroectodermal tumor of the CNS55
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult11
blastocyst16
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2
adrenal gland4.6
appendix2.5
bone marrow1.7
cerebral cortex12.9
colon4.9
duodenum23
esophagus3.6
gallbladder6
heart muscle1.7
kidney4.1
liver2.3
lung8.6
lymph node1.6
ovary3.4
pancreas1.6
placenta4.2
prostate4.4
salivary gland2.8
skin2.9
small intestine5
spleen1.5
stomach11.1
testis1.7
thyroid gland5
urinary bladder7.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600620, gene) Fk506-binding protein 1b; FKBP1BOMIM


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