Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P68400)
Protein (NX_P68400)
Protein
Gene SymbolCSNK2A1 to neXtProt (NX_P68400)
DescriptionCasein kinase II subunit alpha
Chromosome20
Location20p13 (459116 ~ 524465) to Ensembl
Sequene Features : Isoforms 2, Variants 51, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 51 5
2014-09-19protein level
2 40 5
2014-05-27protein level
2 40 14
2014-02-25protein level
2 38 14
2013-12-09protein level
2 34 14
2013-11-01protein level
2 33 11
2013-09-12protein level
2 33 11
2013-08-17protein level
2 33 11
2013-07-15protein level
2 20 7
2013-06-11protein level
2 20 7
2013-02-12protein level
2 12 22
2012-12-20protein level
2 12 22
2012-10-30protein level
2 15 22
2012-10-07protein level
2 15 14
2012-08-24protein level
2 10 14
2012-07-28protein level
2 10 14
2012-06-08protein level
2 14 14
2012-05-07protein level
2 14 14
2012-04-10protein level
2 14 14
2012-01-13protein level
2 16 14
2011-12-20protein level
2 16 14
2011-11-11protein level
2 16 14
2011-08-23protein level
1 16 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P68400-1
0 3 15 45114.6713
NX_P68400-2
0 3 7 29162.2578
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347804,EBI-4392727 CBX4  
  .negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
2 EBI-347804,EBI-717170 KIF5C  
  .mRNA transport
.cytoskeleton-dependent intracellular transport
.metabolic process
  + 4 more...
.ATPase activity
.ATP-dependent microtubule motor activity, plus-end-directed
.ATP binding
.microtubule motor activity
.microtubule
.kinesin complex
.cytoplasm
3 EBI-347804,EBI-366647 EIF3J  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.translation initiation factor activity .eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.eukaryotic translation initiation factor 3 complex
.cytosol
4 EBI-347804,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-347804,EBI-347451 CSNK2A2  
  .mitotic spindle checkpoint
.Wnt signaling pathway
.axon guidance
  + 4 more...
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.nucleus
6 EBI-347804,EBI-389739 NFYA  
  .positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
7 EBI-347804,EBI-295890 PML  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of double-strand break repair
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 57 more...
.cobalt ion binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extrinsic component of endoplasmic reticulum membrane
.nuclear membrane
.early endosome membrane
  + 7 more...
8 EBI-347804,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
9 EBI-347804,EBI-348169 CSNK2B  
  .endothelial tube morphogenesis
.regulation of DNA binding
.regulation of protein kinase activity
  + 11 more...
.metal ion binding
.identical protein binding
.protein domain specific binding
  + 4 more...
.extracellular exosome
.protein kinase CK2 complex
.cytosol
  + 2 more...
10 EBI-347804,EBI-353771 SSRP1  
  .positive regulation of viral transcription
.viral process
.gene expression
  + 6 more...
.poly(A) RNA binding
.chromatin binding
.DNA binding
.cytoplasm
.nucleolus
.chromosome
  + 2 more...
11 EBI-347804,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
12 EBI-347804,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
13 EBI-347804,EBI-1051105 SLC39A7  
  .transmembrane transport
.zinc II ion transport
.metal ion transmembrane transporter activity .integral component of membrane
.membrane
.Golgi apparatus
  + 3 more...
14 EBI-347804,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
15 EBI-347804,EBI-745680 STAC3  
  .skeletal muscle fiber development
.intracellular signal transduction
.neuromuscular synaptic transmission
.skeletal muscle contraction
.metal ion binding
.identical protein binding
.N/A
16 EBI-347804,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder100
blood8
bone13
bone marrow41
brain10
cervix20
connective tissue20
embryonic tissue18
esophagus198
eye19
heart11
intestine25
kidney9
larynx85
liver34
lung2
lymph22
lymph node33
mammary gland6
mouth226
muscle131
nerve64
ovary9
pancreas4
parathyroid48
pharynx24
pituitary gland121
placenta7
prostate10
skin9
spleen37
stomach10
testis25
thymus225
thyroid21
trachea173
umbilical cord72
uterus56
vascular116
Health State
TissuesTPM*
normal13
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma24
colorectal tumor44
esophageal tumor231
gastrointestinal tumor16
germ cell tumor26
glioma9
head and neck tumor7
kidney tumor14
leukemia31
liver tumor52
lung tumor9
lymphoma13
non-neoplasia20
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma86
skin tumor23
soft tissue/muscle tissue tumor79
uterine tumor44
Developmental Stage
TissuesTPM*
adult10
embryoid body14
blastocyst48
neonate64
fetus10
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.5
adrenal gland16.8
appendix15.9
bone marrow11.9
cerebral cortex21.3
colon19.9
duodenum16.5
esophagus17.1
gallbladder15.6
heart muscle19
kidney17.8
liver9.1
lung13.7
lymph node19.4
ovary20.3
pancreas9
placenta17.4
prostate17.6
salivary gland14.5
skin16.4
small intestine17.5
spleen14.7
stomach20.5
testis18.3
thyroid gland19.1
urinary bladder19.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*115440, gene) Casein kinase ii, alpha-1; CSNK2A1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center