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> Protein (NX_P68431)
Protein (NX_P68431)
Protein
Gene SymbolHIST1H3A to neXtProt (NX_P68431)
DescriptionHistone H3.1
Chromosome6
Location6p22.2 (26020718 ~ 26021186) to Ensembl
Sequene Features : Isoforms 1, Variants 34, PTMs 57 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 34 57
2014-09-19protein level
1 172 57
2014-05-27protein level
1 171 63
2014-02-25protein level
1 139 61
2013-12-09protein level
1 120 61
2013-11-01protein level
1 119 59
2013-09-12protein level
1 119 57
2013-08-17protein level
1 119 57
2013-07-15protein level
1 84 55
2013-06-11protein level
1 84 55
2013-02-12protein level
1 33 52
2012-12-20protein level
1 33 52
2012-10-30protein level
1 34 46
2012-10-07protein level
1 34 46
2012-08-24protein level
1 29 46
2012-07-28protein level
1 28 46
2012-06-08protein level
1 33 46
2012-05-07protein level
1 15 43
2012-04-10protein level
1 11 43
2012-01-13protein level
1 6 43
2011-12-20protein level
1 6 43
2011-11-11protein level
1 6 46
2011-08-23protein level
1 5 43
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P68431-1
1 0 2 15394.4363
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-79722,EBI-2560834 PHF20L1  
  .N/A .zinc ion binding .N/A
2 EBI-79722,EBI-1753081 AIRE  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.humoral immune response
  + 2 more...
.translation regulator activity
.transcription regulatory region DNA binding
.histone binding
  + 4 more...
.cytoplasm
.nucleus
3 EBI-79722,EBI-936709 KDM4A  
  .histone H3-K36 demethylation
.negative regulation of transcription, DNA-templated
.histone demethylation
  + 4 more...
.histone demethylase activity (H3-K36 specific)
.methylated histone binding
.ubiquitin protein ligase binding
.zinc ion binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
4 EBI-79722,EBI-4304679 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
5 EBI-79722,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
6 EBI-79722,EBI-78219 CBX5  
  .negative regulation of transcription, DNA-templated
.viral process
.blood coagulation
.repressing transcription factor binding
.methylated histone binding
.protein binding, bridging
.chromatin binding
.histone methyltransferase complex
.nuclear pericentric heterochromatin
.transcriptional repressor complex
  + 8 more...
7 EBI-79722,EBI-7038920 NASP  
  .histone exchange
.protein transport
.cell proliferation
  + 6 more...
.Hsp90 protein binding
.protein complex binding
.protein complex
.cytoplasm
.nucleoplasm
  + 2 more...
8 EBI-79722,EBI-540834 WDR5  
  .histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
9 EBI-79722,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
10 EBI-79722,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
11 EBI-79722,EBI-78129 CBX1  
  .negative regulation of transcription, DNA-templated .histone methyltransferase binding
.enzyme binding
.chromatin binding
.chromocenter
.spindle
.pericentric heterochromatin
  + 6 more...
12 EBI-79722,EBI-591370 KMT2A  
  .positive regulation of cellular response to drug
.regulation of histone H3-K9 acetylation
.histone H3-K4 trimethylation
  + 16 more...
.lysine-acetylated histone binding
.unmethylated CpG binding
.transcription regulatory region DNA binding
  + 8 more...
.MLL1 complex
.histone methyltransferase complex
.cytoplasm
  + 2 more...
13 EBI-79722,EBI-396540 TP53BP1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 5 more...
.telomeric DNA binding
.methylated histone binding
.damaged DNA binding
  + 3 more...
.cytoplasm
.replication fork
.nucleoplasm
  + 2 more...
14 EBI-79722,EBI-78176 CBX3  
  .rhythmic process
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin remodeling
.histone methyltransferase binding
.identical protein binding
.protein domain specific binding
.enzyme binding
.nuclear pericentric heterochromatin
.spindle
.nuclear heterochromatin
  + 8 more...
15 EBI-79722,EBI-1268586 SETD7  
  .heterochromatin organization
.peptidyl-lysine dimethylation
.peptidyl-lysine monomethylation
  + 5 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
16 EBI-79722,EBI-3864120 FBLIM1  
  .cell junction assembly
.regulation of integrin activation
.single organismal cell-cell adhesion
.regulation of cell shape
.filamin binding
.zinc ion binding
.cell cortex
.focal adhesion
.cytosol
.stress fiber
17 EBI-79722,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
18 EBI-79722,EBI-2653928 MPHOSPH8  
  .negative regulation of transcription, DNA-templated
.regulation of DNA methylation
.transcription, DNA-templated
.methylated histone binding .extracellular exosome
.plasma membrane
.cytoplasm
  + 5 more...
19 EBI-79722,EBI-2560802 PHF20  
  .histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 3 more...
.zinc ion binding
.DNA binding
.MLL1 complex
.nuclear membrane
.cytoplasm
  + 2 more...
20 EBI-79722,EBI-2866661 ING4  
  .negative regulation of growth
.negative regulation of transcription, DNA-templated
.histone H4-K12 acetylation
  + 11 more...
.methylated histone binding
.zinc ion binding
.transcription coactivator activity
.nucleoplasm
.nucleus
.histone acetyltransferase complex
21 EBI-79722,EBI-1387386 CDYL  
  .negative regulation of nucleic acid-templated transcription
.spermatogenesis
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.methylated histone binding
.histone acetyltransferase activity
.transcription corepressor activity
.nucleoplasm
.nucleus
22 EBI-79722,EBI-1265089 L3MBTL1  
  .regulation of cell cycle
.negative regulation of transcription, DNA-templated
.regulation of megakaryocyte differentiation
  + 4 more...
.identical protein binding
.histone binding
.methylated histone binding
  + 6 more...
.plasma membrane
.nucleoplasm
.nucleus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood16
brain1
connective tissue6
esophagus49
intestine8
kidney4
liver4
lung5
lymph node11
mammary gland6
prostate5
skin4
testis2
uterus4
Health State
TissuesTPM*
normal1
breast (mammary gland) tumor10
cervical tumor28
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
glioma18
head and neck tumor7
kidney tumor14
liver tumor20
lung tumor9
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult1
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.3
bone marrow3.9
colon2.2
duodenum3.1
heart muscle1.8
prostate2
small intestine3.3
stomach1.4
testis1.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
breast cancer
carcinoid
carcinoid
cervical cancer
cervical cancer
colorectal cancer
colorectal cancer
endometrial cancer
endometrial cancer
glioma
glioma
head and neck cancer
head and neck cancer
liver cancer
liver cancer
lung cancer
lung cancer
lymphoma
lymphoma
melanoma
melanoma
ovarian cancer
ovarian cancer
pancreatic cancer
pancreatic cancer
prostate cancer
prostate cancer
renal cancer
renal cancer
skin cancer
skin cancer
stomach cancer
stomach cancer
testis cancer
testis cancer
thyroid cancer
thyroid cancer
urothelial cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602810, gene) Histone gene cluster 1, h3 histone family, member a; HIST1H3AOMIM
2(*602811, gene) Histone gene cluster 1, h3 histone family, member d; HIST1H3DOMIM
3(*602812, gene) Histone gene cluster 1, h3 histone family, member c; HIST1H3COMIM
4(*602813, gene) Histone gene cluster 1, h3 histone family, member e; HIST1H3EOMIM
5(*602814, gene) Histone gene cluster 1, h3 histone family, member i; HIST1H3IOMIM
6(*602815, gene) Histone gene cluster 1, h3 histone family, member g; HIST1H3GOMIM
7(*602816, gene) Histone gene cluster 1, h3 histone family, member f; HIST1H3FOMIM
8(*602817, gene) Histone gene cluster 1, h3 histone family, member j; HIST1H3JOMIM
9(*602818, gene) Histone gene cluster 1, h3 histone family, member h; HIST1H3HOMIM
10(*602819, gene) Histone gene cluster 1, h3 histone family, member b; HIST1H3BOMIM


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