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> Protein (NX_P78314)
Protein (NX_P78314)
Protein
Gene SymbolSH3BP2 to neXtProt (NX_P78314)
DescriptionSH3 domain-binding protein 2
Chromosome4
Location4p16.3 (2794750 ~ 2842825) to Ensembl
Sequene Features : Isoforms 4, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of signal transduction
.signal transduction
.SH3/SH2 adaptor activity .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 70 6
2014-09-19protein level
4 62 6
2014-05-27protein level
3 62 6
2014-02-25protein level
3 62 6
2013-12-09protein level
3 48 6
2013-11-01protein level
3 48 6
2013-09-12protein level
3 48 6
2013-08-17protein level
3 48 6
2013-07-15protein level
3 35 6
2013-06-11protein level
3 35 6
2013-02-12protein level
3 27 10
2012-12-20protein level
3 28 10
2012-10-30protein level
3 28 10
2012-10-07protein level
3 28 5
2012-08-24protein level
3 27 5
2012-07-28protein level
3 27 5
2012-06-08protein level
3 31 5
2012-05-07protein level
3 28 5
2012-04-10protein level
2 28 5
2012-01-13protein level
2 14 5
2011-12-20protein level
2 14 2
2011-11-11protein level
2 14 2
2011-08-23protein level
2 14 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P78314-1
0 26 0 62203.9549
NX_P78314-2
1 4 0 10617.4702
NX_P78314-3
1 25 0 65263.4939
NX_P78314-4
3 25 0 68085.8289
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-727062,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
2 EBI-727062,EBI-625518 VAV1  
  .apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
3 EBI-727062,EBI-297549 VAV2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.ephrin receptor signaling pathway
  + 17 more...
.metal ion binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
4 EBI-727062,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
5 EBI-727062,EBI-4398527 TNKS2  
  .positive regulation of canonical Wnt signaling pathway
.protein auto-ADP-ribosylation
.protein localization to chromosome, telomeric region
  + 6 more...
.metal ion binding
.enzyme binding
.NAD+ ADP-ribosyltransferase activity
.perinuclear region of cytoplasm
.cytosol
.cytoplasm
  + 5 more...
6 EBI-727062,EBI-751783 DBNL  
  .ruffle assembly
.podosome assembly
.neuron projection morphogenesis
  + 8 more...
.actin filament binding
.enzyme activator activity
.actin binding
.extracellular exosome
.clathrin-coated vesicle membrane
.dendrite
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder100
blood155
bone83
bone marrow205
brain40
cervix41
connective tissue46
embryonic tissue32
eye38
heart11
intestine47
kidney90
larynx42
liver38
lung83
lymph22
lymph node11
mammary gland79
mouth30
muscle28
nerve193
ovary29
pharynx24
placenta49
prostate10
salivary gland98
skin33
spleen299
stomach20
testis18
thymus62
thyroid85
tonsil117
uterus43
vascular19
Health State
TissuesTPM*
normal51
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor8
germ cell tumor22
glioma111
head and neck tumor74
kidney tumor72
leukemia127
liver tumor62
lung tumor58
lymphoma13
non-neoplasia62
ovarian tumor26
prostate cancer9
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult53
embryoid body14
blastocyst81
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.2
adrenal gland11.2
appendix42.1
bone marrow45.1
cerebral cortex16.9
colon14.5
duodenum17.4
esophagus10.4
gallbladder16.5
heart muscle8
kidney19
liver10.7
lung24.4
lymph node32.6
ovary8.4
pancreas8.6
placenta22.3
prostate9.6
salivary gland9.8
skin45
small intestine18.5
spleen71.9
stomach23.7
testis11.8
thyroid gland7.2
urinary bladder25.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#118400, phenotype) CherubismOMIM
2(*602104, gene) Sh3 domain-binding protein 2; SH3BP2OMIM


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