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> Protein (NX_P78345)
Protein (NX_P78345)
Protein
Gene SymbolRPP38 to neXtProt (NX_P78345)
DescriptionRibonuclease P protein subunit p38
Chromosome10
Location10p13 (15139179 ~ 15181817) to Ensembl
Sequene Features : Isoforms 1, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, endonucleolytic
.RNA phosphodiester bond hydrolysis
.tRNA processing
.ribonuclease P activity .nucleolar ribonuclease P complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 41 4
2014-09-19protein level
1 39 4
2014-05-27protein level
1 39 4
2014-02-25protein level
1 39 4
2013-12-09protein level
1 29 4
2013-11-01protein level
1 28 4
2013-09-12protein level
1 28 4
2013-08-17protein level
1 28 4
2013-07-15protein level
1 19 3
2013-06-11protein level
1 19 3
2013-02-12protein level
1 12 3
2012-12-20protein level
1 14 3
2012-10-30protein level
1 17 3
2012-10-07protein level
1 17 3
2012-08-24protein level
1 17 3
2012-07-28protein level
1 17 3
2012-06-08protein level
1 18 3
2012-05-07protein level
1 18 3
2012-04-10protein level
1 18 3
2012-01-13protein level
1 12 3
2011-12-20protein level
1 12 3
2011-11-11protein level
1 12 3
2011-08-23protein level
1 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P78345-1
16 0 0 31814.5011
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-366493,EBI-366477 POP4  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.RNA phosphodiester bond hydrolysis
.tRNA processing
  + 2 more...
.ribonuclease P RNA binding
.ribonuclease P activity
.RNA binding
.ribonuclease P complex
.nucleolar ribonuclease P complex
.ribonuclease MRP complex
2 EBI-366493,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone41
bone marrow41
connective tissue6
embryonic tissue32
eye23
heart33
intestine17
kidney33
liver4
lung23
lymph node11
muscle18
pancreas32
placenta28
prostate21
spleen18
stomach10
testis20
thyroid21
uterus4
vascular19
Health State
TissuesTPM*
normal15
chondrosarcoma24
colorectal tumor26
gastrointestinal tumor8
germ cell tumor15
head and neck tumor7
leukemia21
lung tumor9
non-neoplasia10
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma21
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult15
embryoid body14
blastocyst32
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland10.8
appendix13.1
bone marrow8.3
cerebral cortex8.6
colon16.1
duodenum14.2
esophagus15.3
gallbladder12.7
heart muscle8.9
kidney11.5
liver10.4
lung14.2
lymph node19.8
ovary13.3
pancreas7.2
placenta12
prostate12
salivary gland10.6
skin15.5
small intestine13.4
spleen12.8
stomach12.9
testis38.9
thyroid gland16.9
urinary bladder20.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606116, gene) Ribonuclease p/mrp, 38-kd subunit; RPP38OMIM


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