Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P78362)
Protein (NX_P78362)
Protein
Gene SymbolSRPK2 to neXtProt (NX_P78362)
DescriptionSRSF protein kinase 2
Chromosome7
Location7q22.3 (104751151 ~ 105039755) to Ensembl
Sequene Features : Isoforms 2, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 75 9
2014-09-19protein level
2 55 9
2014-05-27protein level
2 55 12
2014-02-25protein level
2 54 12
2013-12-09protein level
2 44 12
2013-11-01protein level
2 43 11
2013-09-12protein level
2 43 11
2013-08-17protein level
2 43 11
2013-07-15protein level
2 30 8
2013-06-11protein level
2 30 8
2013-02-12protein level
2 19 18
2012-12-20protein level
2 19 18
2012-10-30protein level
2 22 18
2012-10-07protein level
2 22 9
2012-08-24protein level
2 15 9
2012-07-28protein level
2 15 9
2012-06-08protein level
2 25 9
2012-05-07protein level
2 25 9
2012-04-10protein level
2 25 9
2012-01-13protein level
2 22 9
2011-12-20protein level
2 22 8
2011-11-11protein level
2 22 8
2011-08-23protein level
2 22 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P78362-1
1 25 3 77477.9368
NX_P78362-2
0 25 3 78979.0621
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-593303,EBI-751531 ZSCAN9  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
2 EBI-593303,EBI-357966 HNRNPC  
  .3'-UTR-mediated mRNA stabilization
.ATP-dependent chromatin remodeling
.gene expression
  + 3 more...
.N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.identical protein binding
  + 7 more...
.catalytic step 2 spliceosome
.extracellular exosome
.protein complex
  + 6 more...
3 EBI-593303,EBI-1049228 SNRNP70  
  .positive regulation of mRNA splicing, via spliceosome
.regulation of RNA splicing
.gene expression
  + 3 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.nuclear speck
.U1 snRNP
.spliceosomal complex
  + 2 more...
4 EBI-593303,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
5 EBI-593303,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
6 EBI-593303,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
7 EBI-593303,EBI-745579 CLK3  
  .protein autophosphorylation
.regulation of RNA splicing
.protein phosphorylation
.poly(A) RNA binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intermediate filament cytoskeleton
.nuclear speck
.membrane
  + 3 more...
8 EBI-593303,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
9 EBI-593303,EBI-632461 U2AF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nuclear speck
.Cajal body
  + 2 more...
10 EBI-593303,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
11 EBI-593303,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
12 EBI-593303,EBI-6657923 ZRSR2  
  .RNA splicing
.mRNA splicing, via spliceosome
.spliceosomal complex assembly
.metal ion binding
.pre-mRNA 3'-splice site binding
.nucleotide binding
.U12-type spliceosomal complex
13 EBI-593303,EBI-398885 SRSF7  
  .negative regulation of mRNA splicing, via spliceosome
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.nucleotide binding
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
14 EBI-593303,EBI-780319 RBM23  
  .mRNA processing .RNA binding
.nucleotide binding
.membrane
.nucleus
15 EBI-593303,EBI-715374 PRPF38A  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .precatalytic spliceosome
.nuclear membrane
.nucleus
16 EBI-593303,EBI-2512550 SNRNP27  
  .RNA splicing
.mRNA processing
.nucleic acid binding .precatalytic spliceosome
17 EBI-593303,EBI-2849854 YTHDC1  
  .mRNA splice site selection .N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.RNA binding
.nuclear body
.nucleus
18 EBI-593303,EBI-6380719 SRSF8  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.nucleotide binding
.nucleus
19 EBI-593303,EBI-742459 MMTAG2  
  .N/A .poly(A) RNA binding .N/A
20 EBI-593303,EBI-473747 LUC7L  
  .negative regulation of striated muscle tissue development
.mRNA splice site selection
.identical protein binding
.mRNA binding
.U1 snRNP
21 EBI-593303,EBI-2808785 ARGLU1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .mitochondrion
.nucleoplasm
22 EBI-593303,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
23 EBI-593303,EBI-352851 LUC7L2  
  .mRNA splice site selection .poly(A) RNA binding
.enzyme binding
.mRNA binding
.nuclear speck
.U1 snRNP
24 EBI-593303,EBI-447231 RBM8A  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 7 more...
.poly(A) RNA binding
.mRNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.exon-exon junction complex
.nuclear speck
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood16
bone55
bone marrow82
brain161
cervix123
connective tissue33
embryonic tissue42
eye67
heart55
intestine38
kidney33
larynx426
liver29
lung44
lymph node33
mammary gland39
mouth45
muscle28
nerve64
ovary29
pancreas23
parathyroid97
pharynx73
pituitary gland60
placenta24
prostate21
skin61
spleen56
stomach20
testis149
thymus87
thyroid128
trachea57
umbilical cord72
uterus77
vascular38
Health State
TissuesTPM*
normal88
bladder carcinoma113
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma48
colorectal tumor44
gastrointestinal tumor33
germ cell tumor45
glioma37
head and neck tumor104
kidney tumor72
leukemia190
liver tumor31
lung tumor77
lymphoma55
non-neoplasia62
ovarian tumor39
pancreatic tumor19
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma86
skin tumor31
soft tissue/muscle tissue tumor79
uterine tumor44
Developmental Stage
TissuesTPM*
adult56
blastocyst81
neonate32
fetus98
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.4
adrenal gland18.5
appendix19.7
bone marrow8.5
cerebral cortex72.8
colon15.3
duodenum12.9
esophagus16.3
gallbladder18.4
heart muscle11.7
kidney13.8
liver9.1
lung14.6
lymph node19.5
ovary17.4
pancreas7.5
placenta15.7
prostate20.5
salivary gland12.2
skin22.7
small intestine11.7
spleen17.4
stomach15.7
testis125.7
thyroid gland18.5
urinary bladder21.8
Tissues
TissuesExpression level
adrenal glandLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonMedium
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderLow
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lymph nodeLow
nasopharynxMedium
parathyroid glandLow
placentaMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Low
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenLow
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602980, gene) Protein kinase, serine/arginine-specific, 2; SRPK2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center