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> Protein (NX_P78537)
Protein (NX_P78537)
Protein
Gene SymbolBLOC1S1 to neXtProt (NX_P78537)
DescriptionBiogenesis of lysosome-related organelles complex 1 subunit 1
Chromosome12
Location12q13.2 (56109820 ~ 56113871) to Ensembl
Sequene Features : Isoforms 2, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.membrane organization
.platelet dense granule organization
  + 7 more...
.N/A .extracellular exosome
.BLOC-1 complex
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 8 2
2014-09-19protein level
2 7 2
2014-05-27protein level
2 7 2
2014-02-25protein level
2 7 2
2013-12-09protein level
2 6 2
2013-11-01protein level
2 6 2
2013-09-12protein level
2 6 2
2013-08-17protein level
2 6 2
2013-07-15protein level
2 5 1
2013-06-11protein level
2 5 1
2013-02-12protein level
2 1 2
2012-12-20protein level
2 2 2
2012-10-30protein level
2 2 2
2012-10-07protein level
2 2 1
2012-08-24protein level
2 2 1
2012-07-28protein level
2 2 1
2012-06-08protein level
2 2 1
2012-05-07protein level
2 2 1
2012-04-10protein level
2 2 1
2012-01-13protein level
2 0 1
2011-12-20protein level
2 0 1
2011-11-11protein level
2 0 1
2011-08-23protein level
2 0 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P78537-1
1 6 0 17251.808
NX_P78537-2
0 6 0 14302.3428
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348630,EBI-351437 ATP5A1  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 6 more...
.proton-transporting ATPase activity, rotational mechanism
.proton-transporting ATP synthase activity, rotational mechanism
.poly(A) RNA binding
  + 3 more...
.extracellular exosome
.proton-transporting ATP synthase complex, catalytic core F(1)
.membrane
  + 5 more...
2 EBI-348630,EBI-1045087 NDUFA9  
  .ubiquinone-6 biosynthetic process
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.coenzyme binding
.protein complex binding
.NADH dehydrogenase (ubiquinone) activity
.NADH dehydrogenase activity
.mitochondrial membrane
.mitochondrial matrix
.mitochondrial respiratory chain complex I
  + 2 more...
3 EBI-348630,EBI-465872 BLOC1S2  
  .mitochondrial outer membrane permeabilization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 8 more...
.gamma-tubulin binding
.protein C-terminus binding
.recycling endosome
.BLOC-1 complex
.centrosome
  + 3 more...
4 EBI-348630,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
5 EBI-348630,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland91
ascites125
blood188
bone41
brain23
connective tissue33
embryonic tissue4
eye52
heart22
intestine4
kidney9
liver9
lung11
lymph158
lymph node11
mammary gland13
mouth15
muscle75
ovary19
pancreas28
placenta7
prostate10
salivary gland148
skin4
spleen18
stomach10
testis4
thymus25
thyroid21
tonsil235
trachea19
uterus12
vascular38
Health State
TissuesTPM*
normal22
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor62
gastrointestinal tumor8
germ cell tumor3
glioma55
head and neck tumor7
kidney tumor58
leukemia21
liver tumor302
lymphoma96
non-neoplasia31
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult22
embryoid body14
blastocyst16
fetus43
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue81.3
adrenal gland101.9
appendix72.8
bone marrow126
cerebral cortex71.8
colon136.1
duodenum122.1
esophagus102.3
gallbladder79.1
heart muscle77.2
kidney124.3
liver96.2
lung79.2
lymph node94.8
ovary78.5
pancreas50.8
placenta66.5
prostate73.9
salivary gland64.3
skin65.2
small intestine114.9
spleen91.4
stomach105.1
testis37
thyroid gland71
urinary bladder84
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601444, gene) Biogenesis of lysosome-related organelles complex 1, subunit 1; BLOC1S1OMIM


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