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> Protein (NX_P84022)
Protein (NX_P84022)
Protein
Gene SymbolSMAD3 to neXtProt (NX_P84022)
DescriptionMothers against decapentaplegic homolog 3
Chromosome15
Location15q22.33 (67356101 ~ 67487533) to Ensembl
Sequene Features : Isoforms 4, Variants 76, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 76 14
2014-09-19protein level
4 63 14
2014-05-27protein level
4 63 14
2014-02-25protein level
4 63 14
2013-12-09protein level
4 60 14
2013-11-01protein level
4 59 14
2013-09-12protein level
4 59 14
2013-08-17protein level
4 59 14
2013-07-15protein level
4 39 13
2013-06-11protein level
4 39 13
2013-02-12protein level
4 18 43
2012-12-20protein level
3 18 34
2012-10-30protein level
3 19 31
2012-10-07protein level
3 19 11
2012-08-24protein level
3 17 11
2012-07-28protein level
3 17 11
2012-06-08protein level
3 39 11
2012-05-07protein level
2 31 11
2012-04-10protein level
2 31 10
2012-01-13protein level
1 25 10
2011-12-20protein level
1 25 10
2011-11-11protein level
1 23 9
2011-08-23protein level
1 21 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P84022-1
4 6 9 48049.6163
NX_P84022-2
0 6 9 43208.8428
NX_P84022-3
1 4 8 35872.0553
NX_P84022-4
1 3 6 25705.3021
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347161,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
2 EBI-347161,EBI-296817 ZFYVE9  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.SMAD protein import into nucleus
.SMAD protein complex assembly
  + 3 more...
.metal ion binding
.serine-type peptidase activity
.1-phosphatidylinositol binding
.early endosome membrane
.early endosome
3 EBI-347161,EBI-347281 SKI  
  .protein homotrimerization
.SMAD protein signal transduction
.bone morphogenesis
  + 34 more...
.repressing transcription factor binding
.histone deacetylase inhibitor activity
.SMAD binding
  + 6 more...
.protein complex
.transcriptional repressor complex
.PML body
  + 6 more...
4 EBI-347161,EBI-1171238 DAB2  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of integrin-mediated signaling pathway
.positive regulation of early endosome to late endosome transport
  + 35 more...
.SMAD binding
.cargo receptor activity
.clathrin adaptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
  + 8 more...
5 EBI-347161,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-347161,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
7 EBI-347161,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
8 EBI-347161,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
9 EBI-347161,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
10 EBI-347161,EBI-2825219 PCK2  
  .cellular response to glucose stimulus
.response to glucocorticoid
.small molecule metabolic process
  + 7 more...
.metal ion binding
.GTP binding
.phosphoenolpyruvate carboxykinase (GTP) activity
.phosphoenolpyruvate carboxykinase activity
.extracellular exosome
.mitochondrial matrix
.mitochondrion
11 EBI-347161,EBI-747793 ZC3H12A  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to lipopolysaccharide
.positive regulation of fat cell differentiation
  + 12 more...
.metal ion binding
.endonuclease activity
.plasma membrane
.cytoplasm
.nucleoplasm
12 EBI-347161,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
13 EBI-347161,EBI-746909 CPSF7  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.membrane
.mRNA cleavage factor complex
.nucleoplasm
.nucleus
14 EBI-347161,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
15 EBI-347161,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
16 EBI-347161,EBI-948111 RNF31  
  .positive regulation of protein targeting to mitochondrion
.protein linear polyubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 4 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.LUBAC complex
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytoplasm
17 EBI-347161,EBI-447470 EPAS1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.iron ion homeostasis
  + 18 more...
.protein heterodimerization activity
.histone acetyltransferase binding
.transcription factor binding
  + 4 more...
.nuclear speck
.cytosol
.transcription factor complex
  + 2 more...
18 EBI-347161,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
19 EBI-347161,EBI-945869 SETD2  
  .histone H3-K36 trimethylation
.coronary vasculature morphogenesis
.embryonic placenta morphogenesis
  + 15 more...
.histone-lysine N-methyltransferase activity .chromosome
.nucleoplasm
20 EBI-347161,EBI-2695893 DOCK9  
  .blood coagulation
.small GTPase mediated signal transduction
.Rho guanyl-nucleotide exchange factor activity .membrane
.endomembrane system
.cytosol
21 EBI-347161,EBI-721802 PPP1R12C  
  .N/A .N/A .cytoplasm
22 EBI-347161,EBI-742157 WWP1  
  .transmembrane transport
.viral entry into host cell
.negative regulation of transcription, DNA-templated
  + 6 more...
.ligase activity
.ubiquitin-protein transferase activity
.extracellular exosome
.plasma membrane
.cytosol
  + 3 more...
23 EBI-347161,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
24 EBI-347161,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
25 EBI-347161,EBI-396727 SMURF2  
  .positive regulation of trophoblast cell migration
.positive regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 11 more...
.ubiquitin protein ligase activity
.SMAD binding
.identical protein binding
  + 2 more...
.membrane raft
.plasma membrane
.cytosol
  + 4 more...
26 EBI-347161,EBI-1052346 MTMR4  
  .small molecule metabolic process
.peptidyl-tyrosine dephosphorylation
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 5 more...
.metal ion binding
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.early endosome membrane
.cytosol
.extracellular space
27 EBI-347161,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites25
bladder100
blood32
bone55
bone marrow41
brain35
cervix41
connective tissue140
embryonic tissue70
esophagus49
eye62
heart156
intestine56
kidney80
liver97
lung50
lymph node66
mammary gland72
mouth136
muscle131
ovary59
pancreas117
pharynx49
placenta24
prostate26
salivary gland197
skin52
spleen93
stomach52
testis18
thymus75
thyroid85
trachea57
uterus8
vascular77
Health State
TissuesTPM*
normal48
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma132
colorectal tumor71
esophageal tumor57
gastrointestinal tumor16
germ cell tumor83
glioma74
head and neck tumor104
kidney tumor101
leukemia31
liver tumor156
lung tumor19
non-neoplasia82
ovarian tumor65
pancreatic tumor209
primitive neuroectodermal tumor of the CNS7
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor71
Developmental Stage
TissuesTPM*
adult58
embryoid body100
blastocyst65
fetus57
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.1
adrenal gland6.2
appendix18.6
bone marrow12
cerebral cortex11.7
colon14.8
duodenum19
esophagus46.5
gallbladder27.3
heart muscle13.5
kidney15.3
liver10.6
lung19.6
lymph node19.4
ovary32.6
pancreas10.4
placenta16.8
prostate13.8
salivary gland11.8
skin26.5
small intestine21.5
spleen17.9
stomach24.1
testis5.6
thyroid gland29.5
urinary bladder44.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114500, phenotype) Colorectal cancer; CRCOMIM
2(*603109, gene) Mothers against decapentaplegic, drosophila, homolog of, 3; SMAD3OMIM
3(#613795, phenotype) Loeys-dietz syndrome, type 3; LDS3OMIM


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