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> Protein (NX_P98077)
Protein (NX_P98077)
Protein
Gene SymbolSHC2 to neXtProt (NX_P98077)
DescriptionSHC-transforming protein 2
Chromosome19
Location19p13.3 (416583 ~ 460996) to Ensembl
Sequene Features : Isoforms 1, Variants 68, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.insulin receptor signaling pathway
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 68 3
2014-09-19protein level
1 58 3
2014-05-27protein level
1 58 3
2014-02-25protein level
1 58 3
2013-12-09protein level
1 35 3
2013-11-01protein level
1 35 3
2013-09-12protein level
1 35 3
2013-08-17protein level
1 35 3
2013-07-15protein level
1 26 3
2013-06-11protein level
1 26 3
2013-02-12protein level
1 13 3
2012-12-20protein level
1 13 3
2012-10-30protein level
1 21 3
2012-10-07protein level
1 21 3
2012-08-24protein level
1 19 3
2012-07-28protein level
1 19 3
2012-06-08protein level
1 28 3
2012-05-07protein level
1 28 3
2012-04-10protein level
1 28 3
2012-01-13protein level
1 20 3
2011-12-20protein level
1 20 3
2011-11-11protein level
1 20 3
2011-08-23protein level
1 20 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P98077-1
27 0 1 61876.9018
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7256023,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-7256023,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-7256023,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-7256023,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
brain22
embryonic tissue4
eye23
heart78
intestine8
kidney4
lung35
mammary gland6
nerve128
pancreas28
placenta14
prostate10
skin4
spleen18
stomach20
testis16
thyroid42
uterus8
Health State
TissuesTPM*
normal18
gastrointestinal tumor8
germ cell tumor3
glioma65
lung tumor38
prostate cancer9
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult11
embryoid body14
fetus39
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12
adrenal gland15.3
appendix2.9
cerebral cortex22
colon3.9
duodenum7.8
esophagus2.6
gallbladder24.6
heart muscle8.3
kidney5.4
liver12.7
lung13.7
lymph node3.3
ovary4
pancreas24.8
placenta14.7
prostate25.6
salivary gland16.9
skin13.3
small intestine6.6
spleen21.3
stomach14.7
testis12.1
thyroid gland12.1
urinary bladder5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605217, gene) Shc transforming protein 2; SHC2OMIM


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