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> Protein (NX_P98082)
Protein (NX_P98082)
Protein
Gene SymbolDAB2 to neXtProt (NX_P98082)
DescriptionDisabled homolog 2
Chromosome5
Location5p13.1 (39371780 ~ 39462402) to Ensembl
Sequene Features : Isoforms 3, Variants 137, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of integrin-mediated signaling pathway
.positive regulation of early endosome to late endosome transport
  + 35 more...
.SMAD binding
.cargo receptor activity
.clathrin adaptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 137 9
2014-09-19protein level
3 101 9
2014-05-27protein level
3 101 9
2014-02-25protein level
3 100 9
2013-12-09protein level
3 81 9
2013-11-01protein level
3 78 9
2013-09-12protein level
3 78 10
2013-08-17protein level
3 78 10
2013-07-15protein level
3 50 9
2013-06-11protein level
3 50 9
2013-02-12protein level
3 28 25
2012-12-20protein level
3 28 25
2012-10-30protein level
3 36 25
2012-10-07protein level
3 36 9
2012-08-24protein level
3 24 9
2012-07-28protein level
3 24 9
2012-06-08protein level
3 33 9
2012-05-07protein level
3 33 9
2012-04-10protein level
3 33 9
2012-01-13protein level
3 24 9
2011-12-20protein level
3 24 9
2011-11-11protein level
3 24 9
2011-08-23protein level
3 24 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P98082-1
1 31 0 82396.7682
NX_P98082-2
1 20 0 58824.3082
NX_P98082-3
0 31 0 80178.8181
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1171238,EBI-910915 LRP6  
  .negative regulation of planar cell polarity pathway involved in neural tube closure
.negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
.negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
  + 77 more...
.coreceptor activity involved in Wnt signaling pathway
.Wnt-activated receptor activity
.protein homodimerization activity
  + 8 more...
.synapse
.receptor complex
.neuronal cell body
  + 7 more...
2 EBI-1171238,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-1171238,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-1171238,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
5 EBI-1171238,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
6 EBI-1171238,EBI-350606 MYO6  
  .cellular response to electrical stimulus
.membrane organization
.regulation of secretion
  + 17 more...
.minus-end directed microfilament motor activity
.actin filament binding
.ADP binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 22 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland242
ascites25
blood40
bone251
bone marrow102
brain79
cervix185
connective tissue234
ear683
embryonic tissue61
esophagus49
eye67
heart167
intestine51
kidney265
larynx213
liver160
lung104
lymph node11
mammary gland125
mouth90
muscle103
nerve128
ovary39
pancreas56
parathyroid194
placenta688
prostate21
salivary gland49
skin351
spleen206
stomach41
testis43
thymus75
thyroid42
trachea96
umbilical cord217
uterus60
vascular329
Health State
TissuesTPM*
normal173
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor260
chondrosarcoma289
colorectal tumor35
esophageal tumor57
gastrointestinal tumor50
germ cell tumor41
glioma65
head and neck tumor97
kidney tumor43
leukemia52
liver tumor135
lung tumor19
lymphoma41
non-neoplasia227
ovarian tumor26
pancreatic tumor19
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor63
uterine tumor44
Developmental Stage
TissuesTPM*
adult176
embryoid body85
neonate418
fetus145
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue58.9
adrenal gland117.6
appendix37.5
bone marrow2.4
cerebral cortex8.2
colon38.1
duodenum12.3
esophagus17.5
gallbladder54.6
heart muscle16.2
kidney148.6
liver15.2
lung46.7
lymph node35.6
ovary33.5
pancreas11.6
placenta251.1
prostate13.9
salivary gland18.5
skin7
small intestine21.4
spleen58.7
stomach18.2
testis15
thyroid gland17.9
urinary bladder49
Tissues
TissuesExpression level
adrenal glandMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
kidneyLow
lungLow
placentaHigh
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601236, gene) Disabled, drosophila, homolog of, 2; DAB2OMIM


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