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> Protein (NX_P98170)
Protein (NX_P98170)
Protein
Gene SymbolXIAP to neXtProt (NX_P98170)
DescriptionE3 ubiquitin-protein ligase XIAP
ChromosomeX
LocationXq25 (122993574 ~ 123047829) to Ensembl
Sequene Features : Isoforms 1, Variants 65, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 65 13
2014-09-19protein level
1 59 13
2014-05-27protein level
1 59 13
2014-02-25protein level
1 59 13
2013-12-09protein level
1 53 14
2013-11-01protein level
1 52 13
2013-09-12protein level
1 52 13
2013-08-17protein level
1 52 13
2013-07-15protein level
1 28 10
2013-06-11protein level
1 28 10
2013-02-12protein level
1 12 8
2012-12-20protein level
1 12 8
2012-10-30protein level
1 13 8
2012-10-07protein level
1 13 8
2012-08-24protein level
1 13 8
2012-07-28protein level
1 13 8
2012-06-08protein level
1 30 8
2012-05-07protein level
1 30 8
2012-04-10protein level
1 30 8
2012-01-13protein level
1 34 5
2011-12-20protein level
1 34 5
2011-11-11protein level
1 34 5
2011-08-23protein level
1 34 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P98170-1
30 0 0 56648.2538
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-517127,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-517127,EBI-4372019 SEPT4  
  .positive regulation of intrinsic apoptotic signaling pathway
.cell division
.sperm capacitation
  + 8 more...
.GTP binding
.structural molecule activity
.GTPase activity
.sperm annulus
.cytoskeleton
.mitochondrion
.nucleus
3 EBI-517127,EBI-358522 RIPK2  
  .cellular response to muramyl dipeptide
.cellular response to peptidoglycan
.cellular response to lipoteichoic acid
  + 57 more...
.CARD domain binding
.protein homodimerization activity
.LIM domain binding
  + 4 more...
.protein complex
.vesicle
.cytoskeleton
  + 2 more...
4 EBI-517127,EBI-517086 HTRA2  
  .positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein targeting to mitochondrion
  + 25 more...
.unfolded protein binding
.serine-type peptidase activity
.peptidase activity
.serine-type endopeptidase activity
.CD40 receptor complex
.mitochondrial membrane
.membrane
  + 9 more...
5 EBI-517127,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
6 EBI-517127,EBI-1183307 ERCC3  
  .regulation of mitotic cell cycle phase transition
.positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
  + 27 more...
.protein N-terminus binding
.3'-5' DNA helicase activity
.peptide binding
  + 10 more...
.holo TFIIH complex
.nucleoplasm
.nucleus
.core TFIIH complex
7 EBI-517127,EBI-712376 RFC5  
  .error-free translesion synthesis
.DNA damage response, detection of DNA damage
.error-prone translesion synthesis
  + 13 more...
.enzyme binding
.ATP binding
.DNA binding
.DNA replication factor C complex
.nucleoplasm
.nucleus
8 EBI-517127,EBI-524064 CASP3  
  .regulation of apoptotic DNA fragmentation
.execution phase of apoptosis
.intrinsic apoptotic signaling pathway
  + 37 more...
.cysteine-type endopeptidase activity involved in execution phase of apoptosis
.cysteine-type endopeptidase activity involved in apoptotic process
.peptidase activity
  + 3 more...
.plasma membrane
.cytosol
.nucleoplasm
.nucleus
9 EBI-517127,EBI-636374 NOTCH1  
  .negative regulation of endothelial cell chemotaxis
.negative regulation of pro-B cell differentiation
.negative regulation of anoikis
  + 125 more...
.sequence-specific DNA binding
.chromatin DNA binding
.enzyme binding
  + 6 more...
.receptor complex
.integral component of membrane
.cell surface
  + 9 more...
10 EBI-517127,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
11 EBI-517127,EBI-523958 CASP7  
  .execution phase of apoptosis
.intrinsic apoptotic signaling pathway
.programmed cell death
  + 4 more...
.cysteine-type endopeptidase activity involved in execution phase of apoptosis
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-517127,EBI-516799 CASP9  
  .regulation of response to DNA damage stimulus
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
  + 23 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.protein kinase binding
.SH3 domain binding
  + 3 more...
.apoptosome
.cytosol
.mitochondrion
.nucleus
13 EBI-517127,EBI-4422308 RIPK4  
  .positive regulation of NF-kappaB transcription factor activity
.morphogenesis of an epithelium
.ATP binding
.protein serine/threonine kinase activity
.membrane
.cytoplasm
.nucleus
14 EBI-517127,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
15 EBI-517127,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
16 EBI-517127,EBI-1052908 UBE2N  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of ubiquitin-protein transferase activity
  + 29 more...
.ubiquitin protein ligase activity
.poly(A) RNA binding
.ubiquitin binding
  + 5 more...
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
17 EBI-517127,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
18 EBI-517127,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
19 EBI-517127,EBI-1050671 UBE2V1  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of NF-kappaB transcription factor activity
  + 22 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
20 EBI-517127,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
21 EBI-517127,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
22 EBI-517127,EBI-495095 CASP10  
  .apoptotic signaling pathway
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 3 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.ubiquitin protein ligase binding
.cysteine-type endopeptidase activity
.ripoptosome
.CD95 death-inducing signaling complex
.cytosol
23 EBI-517127,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
24 EBI-517127,EBI-517508 DIABLO  
  .intrinsic apoptotic signaling pathway
.neuron apoptotic process
.positive regulation of apoptotic process
  + 6 more...
.N/A .CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
25 EBI-517127,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
26 EBI-517127,EBI-359276 TRAF6  
  .positive regulation of transcription regulatory region DNA binding
.apoptotic signaling pathway
.cellular response to lipopolysaccharide
  + 61 more...
.protein N-terminus binding
.protein kinase B binding
.histone deacetylase binding
  + 10 more...
.perinuclear region of cytoplasm
.protein complex
.CD40 receptor complex
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood24
bone55
bone marrow20
brain20
cervix20
connective tissue6
ear62
embryonic tissue4
esophagus99
eye38
heart55
intestine56
kidney61
liver24
lung56
lymph node66
mammary gland19
mouth45
muscle9
nerve64
ovary29
pancreas56
pharynx49
placenta38
prostate47
skin42
stomach52
testis4
thymus25
thyroid21
trachea19
vascular58
Health State
TissuesTPM*
normal2
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma48
colorectal tumor79
esophageal tumor115
gastrointestinal tumor8
germ cell tumor30
glioma18
head and neck tumor29
kidney tumor101
leukemia21
liver tumor10
lung tumor9
non-neoplasia62
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer28
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult3
neonate32
fetus39
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10
adrenal gland9.3
appendix10.5
bone marrow6.5
cerebral cortex11.6
colon14.8
duodenum9.8
esophagus10.7
gallbladder11.1
heart muscle6.9
kidney14.9
liver8.4
lung10.2
lymph node11.3
ovary8.4
pancreas3.9
placenta8.6
prostate10
salivary gland6.8
skin8.6
small intestine10.8
spleen11.2
stomach11.3
testis6
thyroid gland17.7
urinary bladder11.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300079, gene) Inhibitor of apoptosis, x-linked; XIAPOMIM
2(#300635, phenotype) Lymphoproliferative syndrome, x-linked, 2; XLP2OMIM


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