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> Protein (NX_P98175)
Protein (NX_P98175)
Protein
Gene SymbolRBM10 to neXtProt (NX_P98175)
DescriptionRNA-binding protein 10
ChromosomeX
LocationXp11.23 (47004268 ~ 47046212) to Ensembl
Sequene Features : Isoforms 4, Variants 92, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 92 18
2014-09-19protein level
4 68 18
2014-05-27protein level
4 68 18
2014-02-25protein level
4 68 17
2013-12-09protein level
4 64 17
2013-11-01protein level
4 61 17
2013-09-12protein level
4 61 17
2013-08-17protein level
4 61 17
2013-07-15protein level
4 38 17
2013-06-11protein level
4 38 17
2013-02-12protein level
4 17 56
2012-12-20protein level
4 15 56
2012-10-30protein level
4 18 56
2012-10-07protein level
4 18 15
2012-08-24protein level
4 18 15
2012-07-28protein level
4 18 15
2012-06-08protein level
4 13 15
2012-05-07protein level
4 13 15
2012-04-10protein level
4 13 15
2012-01-13protein level
4 8 15
2011-12-20protein level
4 8 15
2011-11-11protein level
4 8 14
2011-08-23protein level
4 8 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P98175-1
0 36 1 103469.0658
NX_P98175-2
0 36 1 103369.9977
NX_P98175-3
0 32 1 94411.0086
NX_P98175-4
0 32 1 94311.9405
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-721525,EBI-310697 U2SURP  
  .RNA processing .poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
2 EBI-721525,EBI-1237044 DHX15  
  .RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 2 more...
.cytoplasm
.nucleolus
.U12-type spliceosomal complex
  + 2 more...
3 EBI-721525,EBI-766589 SNRPC  
  .mRNA splicing, via spliceosome
.mRNA 5'-splice site recognition
.spliceosomal snRNP assembly
.poly(A) RNA binding
.protein homodimerization activity
.zinc ion binding
  + 2 more...
.U2-type prespliceosome
.Cajal body
.U1 snRNP
  + 2 more...
4 EBI-721525,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
5 EBI-721525,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-721525,EBI-713456 IK  
  .cell-cell signaling
.immune response
.identical protein binding .nucleolus
.nucleoplasm
.extracellular space
7 EBI-721525,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
8 EBI-721525,EBI-1054743 SF3A1  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.poly(A) RNA binding
.RNA binding
.catalytic step 2 spliceosome
.U2-type prespliceosome
.U2 snRNP
  + 3 more...
9 EBI-721525,EBI-2691671 SUGP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding .spliceosomal complex
.nucleoplasm
10 EBI-721525,EBI-1043041 DHX38  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.catalytic step 2 spliceosome
.membrane
.cytoplasm
  + 2 more...
11 EBI-721525,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
12 EBI-721525,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
13 EBI-721525,EBI-395746 PRPF19  
  .signal transduction involved in DNA damage checkpoint
.protein K63-linked ubiquitination
.positive regulation of astrocyte differentiation
  + 14 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin-ubiquitin ligase activity
.ligase activity
.catalytic step 2 spliceosome
.U2-type catalytic step 1 spliceosome
.site of double-strand break
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites150
bladder33
blood81
bone69
bone marrow20
brain35
cervix123
connective tissue26
embryonic tissue84
esophagus49
eye71
heart44
intestine73
kidney42
larynx42
liver73
lung113
lymph158
lymph node55
mammary gland52
mouth120
muscle94
nerve64
ovary98
pancreas51
pituitary gland60
placenta77
prostate58
salivary gland49
skin90
stomach31
testis13
thyroid107
trachea38
uterus81
vascular19
Health State
TissuesTPM*
normal41
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma48
colorectal tumor79
gastrointestinal tumor75
germ cell tumor79
glioma102
head and neck tumor112
kidney tumor87
leukemia74
liver tumor83
lung tumor175
lymphoma166
non-neoplasia31
ovarian tumor65
pancreatic tumor104
primitive neuroectodermal tumor of the CNS86
prostate cancer77
retinoblastoma64
skin tumor111
soft tissue/muscle tissue tumor159
uterine tumor110
Developmental Stage
TissuesTPM*
adult60
embryoid body128
blastocyst65
neonate32
fetus44
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12
adrenal gland14.7
appendix16.6
bone marrow16.7
cerebral cortex14.5
colon14.3
duodenum13
esophagus14.9
gallbladder12.3
heart muscle13.3
kidney12.7
liver7.2
lung14.4
lymph node21.3
ovary24.3
pancreas9.3
placenta17.2
prostate15.2
salivary gland13.7
skin15
small intestine15.2
spleen20.6
stomach15.2
testis8.8
thyroid gland15.6
urinary bladder14.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300080, gene) Rna-binding motif protein 10; RBM10OMIM
2(#311900, phenotype) Tarp syndrome; TARPSOMIM


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