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> Protein (NX_P99999)
Protein (NX_P99999)
Protein
Gene SymbolCYCS to neXtProt (NX_P99999)
DescriptionCytochrome c
Chromosome7
Location7p15.3 (25159710 ~ 25164980) to Ensembl
Sequene Features : Isoforms 1, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intrinsic apoptotic signaling pathway
.cellular respiration
.small molecule metabolic process
  + 14 more...
.electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
.heme binding
.iron ion binding
.respiratory chain
.cytosol
.mitochondrial intermembrane space
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 18 6
2014-09-19protein level
1 16 6
2014-05-27protein level
1 16 6
2014-02-25protein level
1 16 6
2013-12-09protein level
1 12 6
2013-11-01protein level
1 12 4
2013-09-12protein level
1 12 4
2013-08-17protein level
1 12 4
2013-07-15protein level
1 7 4
2013-06-11protein level
1 7 4
2013-02-12protein level
1 5 4
2012-12-20protein level
1 5 4
2012-10-30protein level
1 5 4
2012-10-07protein level
1 5 4
2012-08-24protein level
1 3 4
2012-07-28protein level
1 3 4
2012-06-08protein level
1 5 4
2012-05-07protein level
1 17 4
2012-04-10protein level
1 17 4
2012-01-13protein level
1 21 4
2011-12-20protein level
1 21 4
2011-11-11protein level
1 21 4
2011-08-23protein level
1 21 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P99999-1
5 0 0 11741.0927
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-446479,EBI-446492 APAF1  
  .positive regulation of apoptotic signaling pathway
.regulation of apoptotic DNA fragmentation
.intrinsic apoptotic signaling pathway
  + 11 more...
.ADP binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.ATP binding
.nucleotide binding
.extracellular exosome
.apoptosome
.cytosol
.nucleus
2 EBI-446479,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
3 EBI-446479,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland212
ascites50
bladder7669
blood204
bone237
bone marrow4349
brain477
cervix144
connective tissue46
embryonic tissue220
esophagus49
eye143
heart156
intestine185
kidney844
larynx42
liver297
lung185
lymph112
lymph node100
mammary gland92
mouth45
muscle620
nerve64
ovary167
pancreas93
parathyroid485
pharynx171
pituitary gland121
placenta91
prostate284
salivary gland5674
skin341
spleen37
stomach83
testis321
thymus25
thyroid107
trachea38
umbilical cord72
uterus180
vascular38
Health State
TissuesTPM*
normal165
adrenal tumor474
bladder carcinoma12852
breast (mammary gland) tumor128
cervical tumor202
chondrosarcoma48
colorectal tumor168
esophageal tumor57
gastrointestinal tumor101
germ cell tumor398
glioma802
head and neck tumor44
kidney tumor2061
leukemia2201
liver tumor197
lung tumor126
lymphoma193
non-neoplasia62
ovarian tumor210
pancreatic tumor57
primitive neuroectodermal tumor of the CNS55
prostate cancer462
retinoblastoma236
skin tumor454
soft tissue/muscle tissue tumor135
uterine tumor188
Developmental Stage
TissuesTPM*
adult126
embryoid body185
blastocyst260
neonate32
fetus86
infant85
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue55.1
adrenal gland88.9
appendix67.7
bone marrow35.6
cerebral cortex80
colon181.1
duodenum105.8
esophagus76.9
gallbladder47.2
heart muscle271.8
kidney89.8
liver43.9
lung33.3
lymph node46.6
ovary18.4
pancreas14.4
placenta31
prostate39
salivary gland34.7
skin21.9
small intestine87.6
spleen30.7
stomach65.2
testis42.5
thyroid gland56.8
urinary bladder58.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123970, gene) Cytochrome c, somatic; CYCSOMIM
2(#612004, phenotype) Thrombocytopenia 4; THC4OMIM


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