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> Protein (NX_Q00005)
Protein (NX_Q00005)
Protein
Gene SymbolPPP2R2B to neXtProt (NX_Q00005)
DescriptionSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Chromosome5
Location5q32 (145967936 ~ 146464347) to Ensembl
Sequene Features : Isoforms 7, Variants 87, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein phosphatase type 2A activity
.signal transduction
.apoptotic process
.protein phosphatase type 2A regulator activity .cytoskeleton
.mitochondrial outer membrane
.mitochondrion
.protein phosphatase type 2A complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 87 3
2014-09-19protein level
7 64 3
2014-05-27protein level
7 64 3
2014-02-25protein level
7 64 3
2013-12-09protein level
7 53 3
2013-11-01protein level
7 49 3
2013-09-12protein level
7 49 3
2013-08-17protein level
7 49 3
2013-07-15protein level
7 28 0
2013-06-11protein level
7 28 0
2013-02-12protein level
6 13 0
2012-12-20protein level
5 17 0
2012-10-30protein level
5 17 0
2012-10-07protein level
5 17 0
2012-08-24protein level
5 8 0
2012-07-28protein level
5 8 0
2012-06-08protein level
5 13 0
2012-05-07protein level
5 13 0
2012-04-10protein level
5 13 0
2012-01-13protein level
5 9 0
2011-12-20protein level
5 9 0
2011-11-11protein level
5 9 0
2011-08-23protein level
5 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q00005-1
1 11 5 51677.4877
NX_Q00005-2
1 10 5 51983.6974
NX_Q00005-3
2 10 5 52032.7664
NX_Q00005-4
1 13 5 58133.6446
NX_Q00005-5
1 13 5 58859.1153
NX_Q00005-6
2 10 5 50338.8025
NX_Q00005-7
3 13 5 62464.7593
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1052159,EBI-717097 PDPK1  
  .extrinsic apoptotic signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.cellular response to epidermal growth factor stimulus
  + 38 more...
.phospholipase binding
.kinase activity
.phospholipase activator activity
  + 3 more...
.cell projection
.cytoplasmic membrane-bounded vesicle
.focal adhesion
  + 4 more...
2 EBI-1052159,EBI-1775921 RPS6KB1  
  .negative regulation of extrinsic apoptotic signaling pathway
.cellular response to growth factor stimulus
.response to glucocorticoid
  + 37 more...
.peptide binding
.ATP binding
.protein serine/threonine/tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.synapse
.neuron projection
  + 8 more...
3 EBI-1052159,EBI-302388 PPP2R1A  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain18
cervix20
connective tissue40
ear62
embryonic tissue28
eye52
intestine8
kidney56
lung8
nerve64
pancreas28
parathyroid48
placenta17
stomach20
testis43
umbilical cord72
Health State
TissuesTPM*
normal5
germ cell tumor68
glioma46
kidney tumor145
non-neoplasia82
primitive neuroectodermal tumor of the CNS39
retinoblastoma21
soft tissue/muscle tissue tumor55
Developmental Stage
TissuesTPM*
adult39
blastocyst16
neonate32
fetus23
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.9
adrenal gland13.3
appendix2.6
bone marrow1.1
cerebral cortex87.8
colon1.7
duodenum1.5
esophagus3.8
gallbladder2.6
heart muscle3.5
kidney5.9
lung2.4
lymph node3.2
placenta4.4
prostate2.2
salivary gland1.1
skin2.5
small intestine2.1
spleen2.6
stomach1.3
testis23.1
thyroid gland2.5
urinary bladder16.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604325, gene) Protein phosphatase 2, regulatory subunit b, beta; PPP2R2BOMIM
2(#604326, phenotype) Spinocerebellar ataxia 12; SCA12OMIM


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