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> Protein (NX_Q00059)
Protein (NX_Q00059)
Protein
Gene SymbolTFAM to neXtProt (NX_Q00059)
DescriptionTranscription factor A, mitochondrial
Chromosome10
Location10q21.1 (60144782 ~ 60158981) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.mitochondrial respiratory chain complex assembly
  + 8 more...
.mitochondrial light strand promoter sense binding
.poly(A) RNA binding
.DNA binding, bending
  + 4 more...
.mitochondrial nucleoid
.cytosol
.mitochondrial matrix
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 12
2014-09-19protein level
2 21 12
2014-05-27protein level
2 21 12
2014-02-25protein level
2 21 12
2013-12-09protein level
2 18 12
2013-11-01protein level
2 18 10
2013-09-12protein level
2 18 10
2013-08-17protein level
2 18 10
2013-07-15protein level
1 12 6
2013-06-11protein level
1 12 6
2013-02-12protein level
1 4 5
2012-12-20protein level
1 3 5
2012-10-30protein level
1 4 5
2012-10-07protein level
1 4 5
2012-08-24protein level
1 4 5
2012-07-28protein level
1 4 5
2012-06-08protein level
1 5 5
2012-05-07protein level
1 5 5
2012-04-10protein level
1 5 5
2012-01-13protein level
1 4 5
2011-12-20protein level
1 4 5
2011-11-11protein level
1 4 4
2011-08-23protein level
1 4 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q00059-1
2 8 0 29078.0825
NX_Q00059-2
0 8 0 25449.1817
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1049924,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
2 EBI-1049924,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
3 EBI-1049924,EBI-2615570 TFB1M  
  .mitochondrion organization
.organelle organization
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.DNA binding
.rRNA (adenine-N6,N6-)-dimethyltransferase activity
.mitochondrial nucleoid
.mitochondrial matrix
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood114
bone55
bone marrow41
brain32
cervix61
connective tissue6
embryonic tissue51
esophagus198
eye28
heart100
intestine38
kidney85
liver68
lung44
lymph22
lymph node100
mammary gland66
mouth15
muscle9
ovary19
pancreas32
parathyroid48
pharynx98
pituitary gland60
placenta63
prostate42
salivary gland49
skin33
stomach20
testis96
thymus37
thyroid64
trachea38
umbilical cord72
uterus43
vascular38
Health State
TissuesTPM*
normal57
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma24
colorectal tumor53
esophageal tumor231
gastrointestinal tumor33
germ cell tumor87
glioma9
head and neck tumor29
kidney tumor29
leukemia116
liver tumor31
lung tumor19
lymphoma27
non-neoplasia10
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer48
retinoblastoma43
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult41
embryoid body42
blastocyst65
neonate32
fetus59
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.4
adrenal gland20.3
appendix23.8
bone marrow22.9
cerebral cortex12.6
colon23.9
duodenum19.8
esophagus13.5
gallbladder12.5
heart muscle17.1
kidney24.5
liver15.2
lung12.5
lymph node29.3
ovary19.3
pancreas7.6
placenta24.5
prostate17.4
salivary gland13.7
skin7.1
small intestine18.4
spleen18.2
stomach17.4
testis59.3
thyroid gland22.3
urinary bladder19.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600438, gene) Transcription factor a, mitochondrial; TFAMOMIM


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