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> Protein (NX_Q00535)
Protein (NX_Q00535)
Protein
Gene SymbolCDK5 to neXtProt (NX_Q00535)
DescriptionCyclin-dependent-like kinase 5
Chromosome7
Location7q36.1 (150750899 ~ 150755617) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of actin cytoskeleton reorganization
.regulation of synaptic vesicle recycling
.negative regulation of neuron death
  + 63 more...
.tau-protein kinase activity
.ErbB-3 class receptor binding
.acetylcholine receptor activator activity
  + 6 more...
.postsynaptic membrane
.perikaryon
.neuronal cell body
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 9
2014-09-19protein level
2 20 9
2014-05-27protein level
2 20 9
2014-02-25protein level
2 20 9
2013-12-09protein level
2 16 9
2013-11-01protein level
2 16 9
2013-09-12protein level
2 16 9
2013-08-17protein level
2 16 9
2013-07-15protein level
2 10 4
2013-06-11protein level
2 10 4
2013-02-12protein level
2 3 16
2012-12-20protein level
2 3 16
2012-10-30protein level
2 3 16
2012-10-07protein level
2 3 8
2012-08-24protein level
2 1 8
2012-07-28protein level
2 1 8
2012-06-08protein level
2 3 8
2012-05-07protein level
2 4 8
2012-04-10protein level
2 4 8
2012-01-13protein level
2 4 8
2011-12-20protein level
2 4 8
2011-11-11protein level
2 4 8
2011-08-23protein level
1 2 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q00535-1
3 12 1 33283.1171
NX_Q00535-2
0 12 1 29525.0453
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1041567,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
2 EBI-1041567,EBI-748789 CCND2  
  .cell division
.positive regulation of cyclin-dependent protein serine/threonine kinase activity
.cell cycle
.positive regulation of protein phosphorylation
.protein kinase binding .nuclear membrane
.cytosol
.nucleolus
  + 4 more...
3 EBI-1041567,EBI-781416 PPARG  
  .negative regulation of pancreatic stellate cell proliferation
.response to metformin
.cellular response to hyperoxia
  + 64 more...
.alpha-actinin binding
.arachidonic acid binding
.retinoid X receptor binding
  + 15 more...
.RNA polymerase II transcription factor complex
.perinuclear region of cytoplasm
.cytosol
  + 2 more...
4 EBI-1041567,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
5 EBI-1041567,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
6 EBI-1041567,EBI-746189 CDK5R1  
  .positive regulation of protein targeting to membrane
.positive regulation of protein serine/threonine kinase activity
.positive regulation of cell cycle arrest
  + 28 more...
.cadherin binding
.protein serine/threonine kinase activator activity
.protein kinase binding
  + 5 more...
.perinuclear region of cytoplasm
.contractile fiber
.intracellular membrane-bounded organelle
  + 14 more...
7 EBI-1041567,EBI-604615 CABLES1  
  .regulation of cell cycle
.cell division
.blood coagulation
  + 2 more...
.N/A .cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
blood8
bone41
bone marrow82
brain52
connective tissue13
embryonic tissue18
eye43
heart22
intestine4
kidney28
liver19
lung20
mammary gland19
muscle18
ovary39
pancreas14
pharynx24
prostate47
salivary gland49
skin23
testis11
thyroid42
tonsil58
uterus12
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor21
chondrosarcoma72
gastrointestinal tumor16
germ cell tumor7
glioma46
head and neck tumor22
kidney tumor29
leukemia42
liver tumor10
lung tumor29
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer57
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult18
embryoid body14
fetus34
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland9.5
appendix7
bone marrow4.5
cerebral cortex23.3
colon6.5
duodenum7.2
esophagus5.3
gallbladder6.1
heart muscle4.6
kidney10.1
liver4.4
lung5.3
lymph node6.8
ovary3.3
pancreas2.6
placenta5.5
prostate6.6
salivary gland5
skin5.6
small intestine5.4
spleen5.9
stomach5.8
testis4.3
thyroid gland6.9
urinary bladder8.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123831, gene) Cyclin-dependent kinase 5; CDK5OMIM


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