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> Protein (NX_Q00536)
Protein (NX_Q00536)
Protein
Gene SymbolCDK16 to neXtProt (NX_Q00536)
DescriptionCyclin-dependent kinase 16
ChromosomeX
LocationXp11.23 (47077259 ~ 47089396) to Ensembl
Sequene Features : Isoforms 3, Variants 49, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of insulin secretion involved in cellular response to glucose stimulus
.neuron projection development
.growth hormone secretion
  + 3 more...
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.neuron projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 49 17
2014-09-19protein level
3 39 17
2014-05-27protein level
3 39 20
2014-02-25protein level
3 39 20
2013-12-09protein level
3 33 20
2013-11-01protein level
3 33 14
2013-09-12protein level
3 33 14
2013-08-17protein level
3 33 14
2013-07-15protein level
3 19 14
2013-06-11protein level
3 19 14
2013-02-12protein level
1 9 24
2012-12-20protein level
1 8 24
2012-10-30protein level
1 11 24
2012-10-07protein level
1 11 24
2012-08-24protein level
1 11 24
2012-07-28protein level
1 11 24
2012-06-08protein level
1 9 24
2012-05-07protein level
1 9 24
2012-04-10protein level
1 9 24
2012-01-13protein level
1 2 24
2011-12-20protein level
1 2 24
2011-11-11protein level
1 2 22
2011-08-23protein level
1 2 22
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q00536-1
0 18 7 55680.8153
NX_Q00536-2
2 18 7 63417.7246
NX_Q00536-3
1 18 7 56340.1084
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726261,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-726261,EBI-81088 SEC23A  
  .membrane organization
.COPII vesicle coating
.small molecule metabolic process
  + 8 more...
.zinc ion binding .perinuclear region of cytoplasm
.smooth endoplasmic reticulum membrane
.COPII vesicle coat
  + 5 more...
3 EBI-726261,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood73
bone111
bone marrow41
brain151
cervix350
connective tissue53
embryonic tissue169
eye114
heart223
intestine112
kidney104
larynx42
liver63
lung119
lymph90
lymph node66
mammary gland152
mouth30
muscle141
ovary157
pancreas79
placenta109
prostate68
salivary gland98
skin147
spleen56
stomach104
testis107
thymus112
thyroid193
trachea57
umbilical cord72
uterus176
vascular19
Health State
TissuesTPM*
normal113
breast (mammary gland) tumor139
cervical tumor434
chondrosarcoma72
colorectal tumor133
gastrointestinal tumor67
germ cell tumor132
glioma167
head and neck tumor67
kidney tumor203
leukemia116
liver tumor93
lung tumor116
lymphoma180
non-neoplasia175
ovarian tumor131
pancreatic tumor47
primitive neuroectodermal tumor of the CNS204
prostate cancer67
skin tumor151
soft tissue/muscle tissue tumor223
uterine tumor133
Developmental Stage
TissuesTPM*
adult113
embryoid body157
blastocyst260
neonate64
fetus123
infant170
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.4
adrenal gland45.3
appendix36.1
bone marrow58.3
cerebral cortex51.7
colon37.8
duodenum36.7
esophagus43.1
gallbladder31.4
heart muscle81.9
kidney42.9
liver12.3
lung35.3
lymph node31.9
ovary34.1
pancreas19.8
placenta40.7
prostate27.1
salivary gland34.6
skin38.9
small intestine31.4
spleen30.7
stomach33.9
testis54.4
thyroid gland52.4
urinary bladder33.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleHigh
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineHigh
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*311550, gene) Pctaire protein kinase 1; PCTK1OMIM


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