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> Protein (NX_Q01105)
Protein (NX_Q01105)
Protein
Gene SymbolSET to neXtProt (NX_Q01105)
DescriptionProtein SET
Chromosome9
Location9q34.11 (131445703 ~ 131458679) to Ensembl
Sequene Features : Isoforms 4, Variants 28, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 28 16
2014-09-19protein level
4 19 19
2014-05-27protein level
4 19 24
2014-02-25protein level
4 20 21
2013-12-09protein level
4 18 21
2013-11-01protein level
4 18 16
2013-09-12protein level
4 18 16
2013-08-17protein level
4 18 16
2013-07-15protein level
3 9 15
2013-06-11protein level
3 9 15
2013-02-12protein level
3 5 29
2012-12-20protein level
2 4 23
2012-10-30protein level
2 8 23
2012-10-07protein level
2 8 15
2012-08-24protein level
2 8 15
2012-07-28protein level
2 8 15
2012-06-08protein level
2 8 15
2012-05-07protein level
2 8 15
2012-04-10protein level
2 8 15
2012-01-13protein level
2 4 15
2011-12-20protein level
2 4 15
2011-11-11protein level
2 4 13
2011-08-23protein level
2 4 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q01105-1
2 4 4 33468.6144
NX_Q01105-2
1 4 4 32083.628
NX_Q01105-3
1 4 4 30974.1375
NX_Q01105-4
1 4 4 31253.3697
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053182,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-1053182,EBI-476431 PRKAR1A  
  .negative regulation of cAMP-dependent protein kinase activity
.cellular response to glucagon stimulus
.cardiac muscle cell proliferation
  + 20 more...
.protein kinase A catalytic subunit binding
.ubiquitin protein ligase binding
.cAMP binding
  + 2 more...
.ciliary base
.protein complex
.neuromuscular junction
  + 5 more...
3 EBI-1053182,EBI-396235 UBTF  
  .positive regulation of transcription from RNA polymerase I promoter
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 8 more...
.poly(A) RNA binding
.chromatin binding
.DNA binding
.nucleolus
.nucleoplasm
4 EBI-1053182,EBI-355371 TBP  
  .positive regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
  + 12 more...
.repressing transcription factor binding
.transcription regulatory region DNA binding
.enzyme binding
  + 2 more...
.cytoplasm
.nuclear euchromatin
.transcription factor TFIIA complex
  + 4 more...
5 EBI-1053182,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
6 EBI-1053182,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
7 EBI-1053182,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
8 EBI-1053182,EBI-2510659 TAF1C  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 6 more...
.DNA binding .nucleoplasm
9 EBI-1053182,EBI-2510647 TAF1A  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 6 more...
.DNA binding .intracellular membrane-bounded organelle
.microtubule cytoskeleton
.nucleoplasm
  + 2 more...
10 EBI-1053182,EBI-1560239 TAF1B  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 7 more...
.metal ion binding
.TBP-class protein binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.RNA polymerase I core factor complex
.extracellular exosome
.nucleoplasm
.nucleus
11 EBI-1053182,EBI-6309082 FAM111B  
  .N/A .catalytic activity .N/A
12 EBI-1053182,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites301
bladder435
blood229
bone516
bone marrow389
brain85
cervix268
connective tissue167
ear931
embryonic tissue408
esophagus49
eye181
heart368
intestine250
kidney189
larynx852
liver282
lung301
lymph203
lymph node55
mammary gland191
mouth15
muscle150
nerve64
ovary472
pancreas299
parathyroid291
pharynx49
pituitary gland181
placenta151
prostate226
salivary gland246
skin208
spleen93
stomach240
testis142
thymus50
thyroid214
tonsil58
umbilical cord217
uterus292
vascular193
Health State
TissuesTPM*
normal163
adrenal tumor237
bladder carcinoma227
breast (mammary gland) tumor182
cervical tumor376
chondrosarcoma519
colorectal tumor337
esophageal tumor57
gastrointestinal tumor244
germ cell tumor292
glioma130
head and neck tumor231
kidney tumor304
leukemia264
liver tumor249
lung tumor389
lymphoma180
non-neoplasia82
ovarian tumor590
pancreatic tumor495
primitive neuroectodermal tumor of the CNS314
prostate cancer288
retinoblastoma193
skin tumor231
soft tissue/muscle tissue tumor335
uterine tumor321
Developmental Stage
TissuesTPM*
adult254
embryoid body385
blastocyst309
neonate64
fetus245
infant42
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.9
adrenal gland52.3
appendix71
bone marrow51.3
cerebral cortex56.7
colon63.9
duodenum41.5
esophagus49.7
gallbladder44.9
heart muscle39.4
kidney54.4
liver36.9
lung48.9
lymph node85.8
ovary64.1
pancreas26.7
placenta64.1
prostate54.5
salivary gland38.1
skin52.5
small intestine44.1
spleen60.2
stomach52.7
testis34
thyroid gland59.3
urinary bladder58
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600960, gene) Set translocation, myeloid leukemia-associated; SETOMIM
2acute myelogenous leukemiaCGP


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