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> Protein (NX_Q01484)
Protein (NX_Q01484)
Protein
Gene SymbolANK2 to neXtProt (NX_Q01484)
DescriptionAnkyrin-2
Chromosome4
Location4q25 (113739265 ~ 114304896) to Ensembl
Sequene Features : Isoforms 4, Variants 634, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cation channel activity
.positive regulation of calcium ion transmembrane transporter activity
.regulation of calcium ion transmembrane transporter activity
  + 40 more...
.ATPase binding
.ion channel binding
.protein binding, bridging
  + 5 more...
.perinuclear region of cytoplasm
.postsynaptic membrane
.membrane raft
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 634 20
2014-09-19protein level
4 487 20
2014-05-27protein level
4 486 20
2014-02-25protein level
4 482 20
2013-12-09protein level
4 417 20
2013-11-01protein level
4 395 19
2013-09-12protein level
4 395 31
2013-08-17protein level
4 395 31
2013-07-15protein level
4 284 31
2013-06-11protein level
4 284 31
2013-02-12protein level
4 123 74
2012-12-20protein level
4 109 74
2012-10-30protein level
4 129 74
2012-10-07protein level
4 129 27
2012-08-24protein level
4 123 27
2012-07-28protein level
4 123 27
2012-06-08protein level
4 141 27
2012-05-07protein level
4 92 27
2012-04-10protein level
5 92 27
2012-01-13protein level
5 71 27
2011-12-20protein level
5 71 27
2011-11-11protein level
5 71 27
2011-08-23protein level
5 71 27
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q01484-2
0 83 10 205666.1459
NX_Q01484-4
108 82 10 433447.0307
NX_Q01484-5
2 81 10 204623.5894
NX_Q01484-7
2 26 0 63321.5445
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-941975,EBI-1018651 DMD  
  .positive regulation of sodium ion transmembrane transporter activity
.negative regulation of peptidyl-cysteine S-nitrosylation
.regulation of voltage-gated calcium channel activity
  + 23 more...
.nitric-oxide synthase binding
.vinculin binding
.myosin binding
  + 5 more...
.postsynaptic membrane
.synapse
.membrane raft
  + 15 more...
2 EBI-941975,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain203
connective tissue67
ear62
embryonic tissue84
eye134
heart122
intestine30
kidney118
liver9
lung26
muscle141
nerve321
ovary49
pancreas18
pharynx49
prostate21
skin23
spleen37
testis20
thymus37
trachea96
uterus17
vascular19
Health State
TissuesTPM*
normal105
chondrosarcoma24
colorectal tumor17
germ cell tumor11
glioma46
head and neck tumor7
kidney tumor58
non-neoplasia82
ovarian tumor91
prostate cancer9
skin tumor23
soft tissue/muscle tissue tumor47
uterine tumor22
Developmental Stage
TissuesTPM*
adult53
blastocyst97
fetus174
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.7
adrenal gland15.9
appendix17.9
cerebral cortex98.3
colon11.7
duodenum7.4
esophagus20.8
gallbladder32.7
heart muscle98.1
kidney120
liver2.9
lung7.7
lymph node12.6
ovary37.9
pancreas2.3
placenta2.1
prostate9.7
salivary gland2.9
skin5.6
small intestine10
spleen37.7
stomach8.1
testis15
thyroid gland9.3
urinary bladder11
Tissues
TissuesExpression level
adrenal glandMedium
cerebellumMedium
cerebral cortexHigh
colonMedium
gallbladderLow
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
ovaryLow
pancreasLow
soft tissue 1Low
testisLow
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*106410, gene) Ankyrin 2; ANK2OMIM
2(#600919, phenotype) Cardiac arrhythmia, ankyrin-b-relatedOMIM


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