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> Protein (NX_Q01804)
Protein (NX_Q01804)
Protein
Gene SymbolOTUD4 to neXtProt (NX_Q01804)
DescriptionOTU domain-containing protein 4
Chromosome4
Location4q31.21 (146031990 ~ 146101313) to Ensembl
Sequene Features : Isoforms 4, Variants 127, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked deubiquitination .poly(A) RNA binding
.ubiquitin-specific protease activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 127 14
2014-09-19protein level
4 97 14
2014-05-27protein level
4 97 14
2014-02-25protein level
4 98 13
2013-12-09protein level
4 82 13
2013-11-01protein level
4 82 12
2013-09-12protein level
4 82 12
2013-08-17protein level
4 82 12
2013-07-15protein level
4 50 12
2013-06-11protein level
4 50 12
2013-02-12protein level
4 28 26
2012-12-20protein level
4 32 26
2012-10-30protein level
4 36 26
2012-10-07protein level
4 36 13
2012-08-24protein level
4 27 13
2012-07-28protein level
4 26 13
2012-06-08protein level
4 29 13
2012-05-07protein level
4 29 13
2012-04-10protein level
4 29 13
2012-01-13protein level
4 11 13
2011-12-20protein level
4 11 13
2011-11-11protein level
4 11 11
2011-08-23protein level
4 11 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q01804-1
3 45 0 123967.2597
NX_Q01804-3
0 45 0 117008.7506
NX_Q01804-4
0 7 0 17025.175
NX_Q01804-5
1 44 0 116880.6924
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1054396,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-1054396,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
3 EBI-1054396,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
4 EBI-1054396,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites50
bladder66
blood24
bone55
bone marrow20
brain22
connective tissue6
ear62
embryonic tissue51
esophagus49
eye47
heart11
intestine25
kidney37
liver53
lung59
lymph45
lymph node111
mammary gland85
mouth60
muscle103
ovary9
pancreas23
pharynx24
pituitary gland60
placenta28
prostate15
skin37
stomach20
testis41
thymus87
thyroid21
trachea38
uterus56
vascular19
Health State
TissuesTPM*
normal50
bladder carcinoma113
breast (mammary gland) tumor85
chondrosarcoma36
colorectal tumor17
esophageal tumor57
gastrointestinal tumor16
germ cell tumor26
glioma18
head and neck tumor7
kidney tumor43
leukemia31
liver tumor52
lung tumor19
lymphoma27
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor66
Developmental Stage
TissuesTPM*
adult36
embryoid body42
blastocyst65
fetus77
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland12.9
appendix14.2
bone marrow17.1
cerebral cortex8.6
colon10
duodenum9.9
esophagus11.3
gallbladder11.3
heart muscle6
kidney9.5
liver9.7
lung13.5
lymph node13.8
ovary12.2
pancreas4.9
placenta12.2
prostate8.1
salivary gland6.5
skin12.3
small intestine9.3
spleen12.7
stomach9.5
testis25.9
thyroid gland11.4
urinary bladder11.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611744, gene) Otu domain-containing protein 4; OTUD4OMIM


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