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> Protein (NX_Q01844)
Protein (NX_Q01844)
Protein
Gene SymbolEWSR1 to neXtProt (NX_Q01844)
DescriptionRNA-binding protein EWS
Chromosome22
Location22q12.2 (29663998 ~ 29696515) to Ensembl
Sequene Features : Isoforms 6, Variants 75, PTMs 48 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 75 48
2014-09-19protein level
6 54 48
2014-05-27protein level
6 54 48
2014-02-25protein level
6 54 45
2013-12-09protein level
6 44 45
2013-11-01protein level
6 44 42
2013-09-12protein level
6 44 42
2013-08-17protein level
6 44 42
2013-07-15protein level
6 24 42
2013-06-11protein level
6 24 42
2013-02-12protein level
5 8 140
2012-12-20protein level
5 8 140
2012-10-30protein level
5 8 140
2012-10-07protein level
5 8 35
2012-08-24protein level
5 6 35
2012-07-28protein level
5 6 35
2012-06-08protein level
5 8 35
2012-05-07protein level
5 3 35
2012-04-10protein level
2 3 35
2012-01-13protein level
2 6 35
2011-12-20protein level
2 6 35
2011-11-11protein level
2 6 35
2011-08-23protein level
2 6 34
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q01844-1
0 15 0 68435.5126
NX_Q01844-2
1 10 0 61179.2522
NX_Q01844-3
0 15 0 68348.4808
NX_Q01844-4
2 3 0 37596.8261
NX_Q01844-5
1 14 0 68922.7391
NX_Q01844-6
1 14 0 62468.7892
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739737,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-739737,EBI-748817 SEC24D  
  .membrane organization
.COPII vesicle coating
.small molecule metabolic process
  + 8 more...
.zinc ion binding .perinuclear region of cytoplasm
.COPII vesicle coat
.ER to Golgi transport vesicle membrane
  + 3 more...
3 EBI-739737,EBI-749911 SEC24A  
  .positive regulation of cholesterol homeostasis
.membrane organization
.positive regulation of protein secretion
  + 10 more...
.zinc ion binding .perinuclear region of cytoplasm
.COPII vesicle coat
.ER to Golgi transport vesicle membrane
  + 3 more...
4 EBI-739737,EBI-400434 FUS  
  .regulation of nucleic acid-templated transcription
.gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 4 more...
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-739737,EBI-741694 ZNF165  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
6 EBI-739737,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
7 EBI-739737,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
8 EBI-739737,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
9 EBI-739737,EBI-741424 MAPK1IP1L  
  .N/A .N/A .N/A
10 EBI-739737,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
11 EBI-739737,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-739737,EBI-2902395 SSBP3  
  .positive regulation of anterior head development
.head morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.single-stranded DNA binding .protein complex
.nucleus
13 EBI-739737,EBI-438698 RASSF1  
  .negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
14 EBI-739737,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
15 EBI-739737,EBI-724639 PEF1  
  .response to calcium ion
.proteolysis
.protein dimerization activity
.protein heterodimerization activity
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland455
ascites225
bladder535
blood482
bone195
bone marrow389
brain336
cervix288
connective tissue234
ear186
embryonic tissue427
esophagus148
eye359
heart245
intestine275
kidney332
larynx298
liver267
lung164
lymph812
lymph node267
mammary gland178
mouth120
muscle479
nerve450
ovary187
pancreas163
pharynx147
pituitary gland242
placenta370
prostate211
salivary gland197
skin355
spleen580
stomach209
testis280
thymus627
thyroid279
tonsil1057
trachea308
umbilical cord72
uterus374
vascular600
Health State
TissuesTPM*
normal296
adrenal tumor237
bladder carcinoma227
breast (mammary gland) tumor247
cervical tumor347
chondrosarcoma229
colorectal tumor293
esophageal tumor115
gastrointestinal tumor303
germ cell tumor467
glioma307
head and neck tumor194
kidney tumor464
leukemia592
liver tumor385
lung tumor272
lymphoma747
non-neoplasia310
ovarian tumor196
pancreatic tumor180
primitive neuroectodermal tumor of the CNS1055
prostate cancer221
retinoblastoma882
skin tumor398
soft tissue/muscle tissue tumor439
uterine tumor388
Developmental Stage
TissuesTPM*
adult249
embryoid body357
blastocyst585
neonate708
fetus292
infant680
juvenile989
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue75.3
adrenal gland100.7
appendix115.5
bone marrow145.2
cerebral cortex65.7
colon74.4
duodenum101.6
esophagus64.2
gallbladder78.5
heart muscle62.3
kidney60.5
liver43.6
lung89.2
lymph node140
ovary75.5
pancreas42.7
placenta77.8
prostate95.7
salivary gland60
skin95.5
small intestine91.2
spleen115.8
stomach75.3
testis114.6
thyroid gland78.1
urinary bladder75.2
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*133450, gene) Ewing sarcoma breakpoint region 1; EWSR1OMIM
2(#612160, phenotype) Histiocytoma, angiomatoid fibrousOMIM
3(#612219, phenotype) Ewing sarcoma; ESOMIM
4Ewing sarcoma;desmoplastic small round cell tumor;acute lymphocytic leukemia;clear cell sarcoma;sarcoma;myoepitheliomaCGP


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