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> Protein (NX_Q01850)
Protein (NX_Q01850)
Protein
Gene SymbolCDR2 to neXtProt (NX_Q01850)
DescriptionCerebellar degeneration-related protein 2
Chromosome16
Location16p12.2 (22357257 ~ 22448486) to Ensembl
Sequene Features : Isoforms 1, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 42 3
2014-09-19protein level
1 26 3
2014-05-27protein level
1 26 3
2014-02-25protein level
1 25 3
2013-12-09protein level
1 22 3
2013-11-01protein level
1 21 3
2013-09-12protein level
1 21 3
2013-08-17protein level
1 21 3
2013-07-15protein level
1 12 3
2013-06-11protein level
1 12 3
2013-02-12protein level
1 5 0
2012-12-20protein level
1 5 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q01850-1
22 0 0 51822.9206
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1181367,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
2 EBI-1181367,EBI-711909 TTR  
  .thyroid hormone transport
.retinol metabolic process
.extracellular matrix organization
  + 3 more...
.thyroid hormone binding
.identical protein binding
.extracellular exosome
.protein complex
.cytoplasm
  + 2 more...
3 EBI-1181367,EBI-1053725 COX5B  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
4 EBI-1181367,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
5 EBI-1181367,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
6 EBI-1181367,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
7 EBI-1181367,EBI-723426 MRPL28  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
8 EBI-1181367,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
9 EBI-1181367,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
10 EBI-1181367,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
11 EBI-1181367,EBI-10241443 CCDC153  
  .N/A .N/A .N/A
12 EBI-1181367,EBI-6657981 C4orf46  
  .N/A .N/A .cytoplasm
13 EBI-1181367,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
14 EBI-1181367,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
15 EBI-1181367,EBI-747505 C1orf216  
  .N/A .N/A .N/A
16 EBI-1181367,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
17 EBI-1181367,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
18 EBI-1181367,EBI-726510 LENG1  
  .N/A .N/A .N/A
19 EBI-1181367,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
20 EBI-1181367,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
21 EBI-1181367,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
22 EBI-1181367,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
23 EBI-1181367,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
24 EBI-1181367,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
25 EBI-1181367,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
26 EBI-1181367,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
27 EBI-1181367,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
28 EBI-1181367,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
29 EBI-1181367,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
30 EBI-1181367,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
31 EBI-1181367,EBI-748350 RTDR1  
  .N/A .N/A .N/A
32 EBI-1181367,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
33 EBI-1181367,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone13
bone marrow20
brain15
cervix41
connective tissue46
embryonic tissue23
eye81
heart44
intestine64
kidney37
liver29
lung35
lymph node22
mammary gland39
ovary9
pancreas14
pharynx24
placenta24
prostate26
skin18
stomach31
testis64
thymus62
thyroid21
uterus17
vascular19
Health State
TissuesTPM*
normal33
breast (mammary gland) tumor42
cervical tumor57
chondrosarcoma84
colorectal tumor53
gastrointestinal tumor25
germ cell tumor53
glioma37
head and neck tumor7
kidney tumor43
leukemia10
liver tumor41
lung tumor58
lymphoma27
non-neoplasia51
ovarian tumor13
pancreatic tumor28
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult36
embryoid body14
blastocyst32
fetus39
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland12.6
appendix17.7
bone marrow11
cerebral cortex7.3
colon15.4
duodenum24.9
esophagus11
gallbladder22.5
heart muscle7.2
kidney19.1
liver12.5
lung15.5
lymph node22
ovary14.7
pancreas5.7
placenta13.8
prostate15
salivary gland9.3
skin6.8
small intestine19.9
spleen16.8
stomach13.1
testis56.1
thyroid gland46.1
urinary bladder25.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*117340, gene) Cerebellar degeneration-related autoantigen 2; CDR2OMIM


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