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> Protein (NX_Q02108)
Protein (NX_Q02108)
Protein
Gene SymbolGUCY1A3 to neXtProt (NX_Q02108)
DescriptionGuanylate cyclase soluble subunit alpha-3
Chromosome4
Location4q32.1 (156587863 ~ 156653501) to Ensembl
Sequene Features : Isoforms 2, Variants 157, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.relaxation of vascular smooth muscle
.response to defense-related host nitric oxide production
.positive regulation of cGMP biosynthetic process
  + 4 more...
.heme binding
.GTP binding
.receptor activity
.guanylate cyclase activity
.guanylate cyclase complex, soluble
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 157 0
2014-09-19protein level
2 105 0
2014-05-27protein level
2 105 0
2014-02-25protein level
2 102 0
2013-12-09protein level
2 86 0
2013-11-01protein level
2 79 0
2013-09-12protein level
2 79 0
2013-08-17protein level
2 79 0
2013-07-15protein level
2 49 0
2013-06-11protein level
2 49 0
2013-02-12protein level
1 21 0
2012-12-20protein level
1 21 0
2012-10-30protein level
1 24 0
2012-10-07protein level
1 24 0
2012-08-24protein level
1 22 0
2012-07-28protein level
1 23 0
2012-06-08protein level
1 32 0
2012-05-07protein level
1 19 0
2012-04-10protein level
1 19 0
2012-01-13protein level
1 17 0
2011-12-20protein level
1 17 0
2011-11-11protein level
1 17 0
2011-08-23protein level
1 17 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q02108-1
3 33 0 77402.093
NX_Q02108-2
0 33 0 70138.5809
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder33
bone13
bone marrow102
brain41
connective tissue33
ear62
embryonic tissue46
eye105
heart111
intestine12
kidney9
larynx42
liver14
lung2
lymph node33
mammary gland52
mouth15
muscle47
nerve64
ovary29
pancreas51
pharynx49
pituitary gland60
placenta52
prostate126
skin9
spleen74
stomach10
testis4
thymus12
thyroid21
trachea77
umbilical cord72
uterus8
vascular96
Health State
TissuesTPM*
normal66
adrenal tumor158
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
head and neck tumor7
kidney tumor14
leukemia31
liver tumor10
lung tumor9
non-neoplasia51
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer144
skin tumor7
soft tissue/muscle tissue tumor47
Developmental Stage
TissuesTPM*
adult1
embryoid body114
neonate32
fetus52
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.2
adrenal gland8.6
appendix19.5
bone marrow1.4
cerebral cortex14.4
colon11.7
duodenum9.1
esophagus8.7
gallbladder16.2
heart muscle29.7
kidney16
liver4.6
lung21.6
lymph node9.4
ovary6.3
pancreas7.3
placenta21.9
prostate33
salivary gland4.5
skin2.1
small intestine9.9
spleen14.3
stomach6.6
testis1.8
thyroid gland9.8
urinary bladder12.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaLow
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*139396, gene) Guanylate cyclase 1, soluble, alpha-3; GUCY1A3OMIM


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