Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q02487)
Protein (NX_Q02487)
Protein
Gene SymbolDSC2 to neXtProt (NX_Q02487)
DescriptionDesmocollin-2
Chromosome18
Location18q12.1 (28645940 ~ 28682378) to Ensembl
Sequene Features : Isoforms 2, Variants 170, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ventricular cardiac muscle cell action potential
.regulation of heart rate by cardiac conduction
.bundle of His cell-Purkinje myocyte adhesion involved in cell communication
  + 4 more...
.cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
.calcium ion binding
.extracellular exosome
.cytoplasmic vesicle
.desmosome
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 170 7
2014-09-19protein level
2 108 7
2014-05-27protein level
2 108 8
2014-02-25protein level
2 107 8
2013-12-09protein level
2 77 8
2013-11-01protein level
2 71 7
2013-09-12protein level
2 71 7
2013-08-17protein level
2 71 7
2013-07-15protein level
2 38 7
2013-06-11protein level
2 38 7
2013-02-12protein level
2 25 11
2012-12-20protein level
2 23 11
2012-10-30protein level
2 32 11
2012-10-07protein level
2 32 6
2012-08-24protein level
2 30 6
2012-07-28protein level
2 30 6
2012-06-08protein level
2 30 6
2012-05-07protein level
2 30 6
2012-04-10protein level
2 30 6
2012-01-13protein level
2 15 6
2011-12-20protein level
2 15 6
2011-11-11protein level
2 15 6
2011-08-23protein level
2 9 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q02487-1
5 34 4 99898.4589
NX_Q02487-2
0 34 4 93709.7259
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6900677,EBI-1103439 GJA1  
  .positive regulation of behavioral fear response
.regulation of tight junction assembly
.negative regulation of DNA biosynthetic process
  + 57 more...
.gap junction channel activity involved in cell communication by electrical coupling
.gap junction channel activity involved in cardiac conduction electrical coupling
.ion transmembrane transporter activity
  + 2 more...
.extracellular exosome
.membrane raft
.contractile fiber
  + 19 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood8
brain2
connective tissue6
embryonic tissue84
esophagus49
eye33
intestine64
kidney37
larynx170
liver43
lung5
lymph node11
mammary gland79
mouth105
muscle56
ovary78
pancreas9
pharynx73
placenta88
prostate63
testis6
thyroid21
trachea19
uterus17
Health State
TissuesTPM*
normal25
bladder carcinoma113
breast (mammary gland) tumor10
colorectal tumor44
esophageal tumor57
gastrointestinal tumor42
germ cell tumor41
head and neck tumor104
kidney tumor29
leukemia21
liver tumor52
lung tumor9
lymphoma13
non-neoplasia41
ovarian tumor105
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer67
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult42
embryoid body100
blastocyst97
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland1.9
appendix13.8
cerebral cortex1.5
colon53.5
duodenum39
esophagus162.8
gallbladder4.4
heart muscle8.8
kidney5.4
liver3.8
lung6.9
lymph node4
pancreas5.1
placenta23.2
prostate16.9
salivary gland25.1
skin10.6
small intestine40.7
spleen2.1
stomach37.9
testis1.1
thyroid gland4.1
urinary bladder4.7
Tissues
TissuesExpression level
appendixHigh
bronchusLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2Low
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderLow
heart muscleHigh
liverLow
lungLow
nasopharynxMedium
oral mucosaHigh
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleLow
skin 1Low
skin 2High
small intestineHigh
stomach 1Medium
stomach 2Medium
thyroid glandLow
tonsilHigh
urinary bladderLow
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*125645, gene) Desmocollin 2; DSC2OMIM
2(#610476, phenotype) Arrhythmogenic right ventricular dysplasia, familial, 11; ARVD11OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center