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> Protein (NX_Q02556)
Protein (NX_Q02556)
Protein
Gene SymbolIRF8 to neXtProt (NX_Q02556)
DescriptionInterferon regulatory factor 8
Chromosome16
Location16q24.1 (85932409 ~ 85956215) to Ensembl
Sequene Features : Isoforms 1, Variants 74, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to lipopolysaccharide
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 12 more...
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 74 2
2014-09-19protein level
1 59 2
2014-05-27protein level
1 59 2
2014-02-25protein level
1 58 2
2013-12-09protein level
1 50 2
2013-11-01protein level
1 47 1
2013-09-12protein level
1 45 1
2013-08-17protein level
1 45 1
2013-07-15protein level
1 30 1
2013-06-11protein level
1 30 1
2013-02-12protein level
1 13 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 16 0
2012-10-07protein level
1 16 0
2012-08-24protein level
1 14 0
2012-07-28protein level
1 14 0
2012-06-08protein level
1 14 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 12 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q02556-1
23 0 0 48324.907
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2866563,EBI-6115643 IRF6  
  .mammary gland epithelial cell differentiation
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.regulatory region DNA binding
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood114
brain5
connective tissue33
embryonic tissue9
intestine43
kidney23
lung53
lymph225
lymph node189
muscle9
pancreas4
pharynx24
placenta7
prostate10
spleen37
stomach10
thymus37
tonsil117
uterus21
Health State
TissuesTPM*
normal18
chondrosarcoma60
colorectal tumor35
gastrointestinal tumor16
germ cell tumor49
glioma18
kidney tumor14
leukemia179
lung tumor19
lymphoma235
non-neoplasia20
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult24
embryoid body14
neonate32
fetus30
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.7
adrenal gland7.9
appendix81
bone marrow38.6
cerebral cortex7.5
colon23.7
duodenum43
esophagus5.8
gallbladder18.8
heart muscle3.3
kidney5.2
liver15.2
lung21.1
lymph node209.1
ovary2.5
pancreas1.7
placenta10.4
prostate6.9
salivary gland5.4
skin4.1
small intestine38.5
spleen113.4
stomach21.7
testis5.3
thyroid gland3.3
urinary bladder28
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
lungMedium
lymph nodeHigh
skin 1Low
spleenMedium
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601565, gene) Interferon regulatory factor 8; IRF8OMIM


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