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> Protein (NX_Q02930)
Protein (NX_Q02930)
Protein
Gene SymbolCREB5 to neXtProt (NX_Q02930)
DescriptionCyclic AMP-responsive element-binding protein 5
Chromosome7
Location7p14.3 (28338940 ~ 28865511) to Ensembl
Sequene Features : Isoforms 4, Variants 84, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 84 4
2014-09-19protein level
4 63 4
2014-05-27protein level
4 63 4
2014-02-25protein level
4 62 4
2013-12-09protein level
4 48 4
2013-11-01protein level
4 43 3
2013-09-12protein level
4 43 3
2013-08-17protein level
4 43 3
2013-07-15protein level
4 28 3
2013-06-11protein level
4 28 3
2013-02-12protein level
4 10 9
2012-12-20protein level
4 12 9
2012-10-30protein level
4 16 9
2012-10-07protein level
4 16 3
2012-08-24protein level
4 15 3
2012-07-28protein level
4 15 3
2012-06-08protein level
4 17 3
2012-05-07protein level
4 10 3
2012-04-10protein level
4 10 3
2012-01-13protein level
4 11 3
2011-12-20protein level
4 11 3
2011-11-11protein level
4 11 0
2011-08-23protein level
4 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q02930-1
0 17 0 56881.4362
NX_Q02930-2
0 17 0 56001.0384
NX_Q02930-3
0 15 0 53028.7097
NX_Q02930-4
1 9 0 41133.8096
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10192698,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-10192698,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
3 EBI-10192698,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-10192698,EBI-743414 EFEMP2  
  .extracellular matrix organization .calcium ion binding
.extracellular matrix structural constituent
.extracellular exosome
.vesicle
.basement membrane
.extracellular region
5 EBI-10192698,EBI-744510 FOSL1  
  .positive regulation of DNA-templated transcription, initiation
.placenta blood vessel development
.response to cAMP
  + 22 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.neuron projection
.presynaptic membrane
.cytosol
  + 2 more...
6 EBI-10192698,EBI-3893419 FOSL2  
  .response to cAMP
.response to corticosterone
.positive regulation of fibroblast proliferation
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
7 EBI-10192698,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
8 EBI-10192698,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
9 EBI-10192698,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
10 EBI-10192698,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
11 EBI-10192698,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
12 EBI-10192698,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
13 EBI-10192698,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
14 EBI-10192698,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
15 EBI-10192698,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
16 EBI-10192698,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
17 EBI-10192698,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
18 EBI-10192698,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
19 EBI-10192698,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
20 EBI-10192698,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
21 EBI-10192698,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
22 EBI-10192698,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
23 EBI-10192698,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
24 EBI-10192698,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
25 EBI-10192698,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
26 EBI-10192698,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
27 EBI-10192698,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
28 EBI-10192698,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
29 EBI-10192698,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
30 EBI-10192698,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
31 EBI-10192698,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder66
blood114
bone13
brain32
connective tissue80
embryonic tissue37
eye28
heart78
kidney23
larynx42
liver29
lung17
lymph node11
mammary gland19
mouth15
muscle28
ovary9
pancreas18
placenta42
prostate10
salivary gland49
skin14
spleen93
testis16
thymus25
thyroid21
trachea38
uterus47
Health State
TissuesTPM*
normal35
breast (mammary gland) tumor21
chondrosarcoma48
germ cell tumor37
glioma55
head and neck tumor14
kidney tumor14
leukemia52
liver tumor31
lung tumor38
lymphoma13
non-neoplasia103
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor33
Developmental Stage
TissuesTPM*
adult34
embryoid body28
blastocyst16
fetus48
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.7
adrenal gland1.5
appendix8.1
bone marrow4.8
cerebral cortex8.7
colon2.4
duodenum1.2
esophagus4.1
gallbladder14.1
heart muscle9.5
kidney2.8
liver2.1
lung5
pancreas2.4
placenta5.8
prostate1.8
skin1.3
small intestine1.4
spleen6.5
stomach1.9
thyroid gland1.8
urinary bladder5.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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2014-2019 (C) Yonsei Proteome Research Center