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> Protein (NX_Q03001)
Protein (NX_Q03001)
Protein
Gene SymbolDST to neXtProt (NX_Q03001)
DescriptionDystonin
Chromosome6
Location6p12.1 (56322785 ~ 56819426) to Ensembl
Sequene Features : Isoforms 8, Variants 885, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell motility
.intermediate filament cytoskeleton organization
.hemidesmosome assembly
  + 8 more...
.microtubule plus-end binding
.protein homodimerization activity
.protein C-terminus binding
  + 2 more...
.extracellular exosome
.intermediate filament cytoskeleton
.microtubule plus-end
  + 19 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 885 26
2014-09-19protein level
8 697 26
2014-05-27protein level
8 697 28
2014-02-25protein level
8 694 28
2013-12-09protein level
8 529 28
2013-11-01protein level
8 520 27
2013-09-12protein level
8 520 28
2013-08-17protein level
8 520 28
2013-07-15protein level
8 342 28
2013-06-11protein level
8 342 28
2013-02-12protein level
8 179 41
2012-12-20protein level
8 194 41
2012-10-30protein level
8 247 41
2012-10-07protein level
8 247 22
2012-08-24protein level
8 183 22
2012-07-28protein level
8 183 22
2012-06-08protein level
8 32 22
2012-05-07protein level
8 32 22
2012-04-10protein level
8 32 22
2012-01-13protein level
8 32 22
2011-12-20protein level
8 32 22
2011-11-11protein level
8 32 21
2011-08-23protein level
8 32 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q03001-10
1 18 0 50342.2711
NX_Q03001-11
8 0 0 25363.2777
NX_Q03001-12
1 4 0 9215.3575
NX_Q03001-13
14 37 0 102803.9579
NX_Q03001-3
75 59 0 306563.0954
NX_Q03001-7
21 344 6 860124.8678
NX_Q03001-8
2 241 5 590667.8067
NX_Q03001-9
1 155 0 344815.7268
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-310758,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
2 EBI-310758,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
3 EBI-310758,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
4 EBI-310758,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites25
bladder401
blood16
bone195
bone marrow41
brain176
cervix20
connective tissue67
ear248
embryonic tissue70
esophagus694
eye129
heart100
intestine125
kidney56
larynx170
liver151
lung125
mammary gland218
mouth287
muscle244
nerve579
ovary108
pancreas98
parathyroid145
pharynx147
pituitary gland181
placenta123
prostate63
skin123
stomach62
testis45
thymus163
thyroid107
trachea308
uterus168
vascular58
Health State
TissuesTPM*
normal3
bladder carcinoma341
breast (mammary gland) tumor118
cervical tumor28
chondrosarcoma156
colorectal tumor106
esophageal tumor57
gastrointestinal tumor8
germ cell tumor11
glioma83
head and neck tumor209
kidney tumor87
leukemia10
liver tumor93
lung tumor68
non-neoplasia175
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma21
skin tumor87
soft tissue/muscle tissue tumor15
uterine tumor255
Developmental Stage
TissuesTPM*
adult175
embryoid body42
blastocyst48
fetus3
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue66.6
adrenal gland68.1
appendix23.3
bone marrow4.8
cerebral cortex70.6
colon53.8
duodenum35.3
esophagus55.1
gallbladder53.3
heart muscle63.6
kidney43.4
liver46.3
lung98.2
lymph node18.8
ovary71.3
pancreas16
placenta29.4
prostate51.2
salivary gland48.3
skin154
small intestine40.2
spleen38.7
stomach31.2
testis36.4
thyroid gland17.4
urinary bladder43.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*113810, gene) Dystonin; DSTOMIM
2(#614653, phenotype) Neuropathy, hereditary sensory and autonomic, type vi; HSAN6OMIM


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