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> Protein (NX_Q03135)
Protein (NX_Q03135)
Protein
Gene SymbolCAV1 to neXtProt (NX_Q03135)
DescriptionCaveolin-1
Chromosome7
Location7q31.2 (116164839 ~ 116201233) to Ensembl
Sequene Features : Isoforms 2, Variants 28, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of anoikis
  + 84 more...
.inward rectifier potassium channel inhibitor activity
.nitric-oxide synthase binding
.ion channel binding
  + 9 more...
.perinuclear region of cytoplasm
.membrane raft
.protein complex
  + 17 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 28 18
2014-09-19protein level
2 19 18
2014-05-27protein level
2 19 18
2014-02-25protein level
2 19 17
2013-12-09protein level
2 14 17
2013-11-01protein level
2 14 13
2013-09-12protein level
2 14 13
2013-08-17protein level
2 14 13
2013-07-15protein level
2 10 13
2013-06-11protein level
2 10 13
2013-02-12protein level
2 5 20
2012-12-20protein level
2 5 20
2012-10-30protein level
2 3 20
2012-10-07protein level
2 3 14
2012-08-24protein level
2 3 14
2012-07-28protein level
2 3 14
2012-06-08protein level
2 5 14
2012-05-07protein level
2 5 14
2012-04-10protein level
2 5 14
2012-01-13protein level
2 4 14
2011-12-20protein level
2 4 14
2011-11-11protein level
2 4 14
2011-08-23protein level
2 4 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q03135-1
3 7 0 20458.4244
NX_Q03135-2
1 7 0 17011.73
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-603614,EBI-910915 LRP6  
  .negative regulation of planar cell polarity pathway involved in neural tube closure
.negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
.negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
  + 77 more...
.coreceptor activity involved in Wnt signaling pathway
.Wnt-activated receptor activity
.protein homodimerization activity
  + 8 more...
.synapse
.receptor complex
.neuronal cell body
  + 7 more...
2 EBI-603614,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-603614,EBI-493507 NR3C1  
  .negative regulation of glucocorticoid mediated signaling pathway
.cellular response to steroid hormone stimulus
.mammary gland duct morphogenesis
  + 14 more...
.steroid hormone binding
.glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
.zinc ion binding
  + 5 more...
.membrane
.cytosol
.mitochondrial matrix
  + 3 more...
4 EBI-603614,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
5 EBI-603614,EBI-1050999 SCP2  
  .lipid hydroperoxide transport
.protein localization to plasma membrane
.positive regulation of steroid metabolic process
  + 14 more...
.oleic acid binding
.long-chain fatty acyl-CoA binding
.propanoyl-CoA C-acyltransferase activity
  + 4 more...
.extracellular exosome
.protein complex
.intracellular membrane-bounded organelle
  + 6 more...
6 EBI-603614,EBI-2803960 F2R  
  .positive regulation of interleukin-6 secretion
.positive regulation of interleukin-8 secretion
.negative regulation of renin secretion into blood stream
  + 42 more...
.G-protein beta-subunit binding
.thrombin receptor activity
.receptor binding
  + 2 more...
.postsynaptic membrane
.neuromuscular junction
.platelet dense tubular network
  + 8 more...
7 EBI-603614,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
8 EBI-603614,EBI-1215527 ID1  
  .lung vasculature development
.lung morphogenesis
.blood vessel morphogenesis
  + 20 more...
.sequence-specific DNA binding transcription factor activity .Golgi apparatus
.nucleoplasm
.nucleus
9 EBI-603614,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
10 EBI-603614,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
11 EBI-603614,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
12 EBI-603614,EBI-720643 KCNH2  
  .negative regulation of potassium ion export
.positive regulation of potassium ion transmembrane transport
.negative regulation of potassium ion transmembrane transport
  + 17 more...
.voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
.scaffold protein binding
.C3HC4-type RING finger domain binding
  + 7 more...
.perinuclear region of cytoplasm
.cell surface
.voltage-gated potassium channel complex
  + 2 more...
13 EBI-603614,EBI-716617 TXNRD1  
  .nucleobase-containing small molecule metabolic process
.cell redox homeostasis
.small molecule metabolic process
  + 8 more...
.flavin adenine dinucleotide binding
.protein disulfide oxidoreductase activity
.electron carrier activity
.thioredoxin-disulfide reductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1010
adrenal gland60
ascites25
bladder167
blood8
bone460
bone marrow102
brain172
cervix41
connective tissue630
embryonic tissue46
esophagus694
eye90
heart491
intestine142
kidney227
liver121
lung394
mammary gland105
mouth256
muscle103
nerve193
ovary19
pancreas121
pharynx49
placenta289
prostate147
salivary gland49
skin1205
spleen973
stomach125
testis50
thymus37
thyroid150
trachea154
umbilical cord726
uterus456
vascular2168
Health State
TissuesTPM*
normal278
bladder carcinoma170
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma651
colorectal tumor17
esophageal tumor753
gastrointestinal tumor50
germ cell tumor102
glioma298
head and neck tumor44
kidney tumor159
leukemia31
liver tumor197
lung tumor77
non-neoplasia362
ovarian tumor39
pancreatic tumor66
primitive neuroectodermal tumor of the CNS503
prostate cancer9
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor215
uterine tumor55
Developmental Stage
TissuesTPM*
adult142
embryoid body57
blastocyst32
neonate5053
fetus132
infant42
juvenile935
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue432.3
adrenal gland18.2
appendix44.5
cerebral cortex7.5
colon84.4
duodenum30
esophagus124.4
gallbladder149.6
heart muscle203.9
kidney12.2
liver13.4
lung571.9
lymph node28.8
ovary123.8
pancreas12
placenta303.5
prostate96.3
salivary gland24.8
skin80.4
small intestine38.1
spleen166.7
stomach27.1
testis28.2
thyroid gland105.4
urinary bladder173.7
Tissues
TissuesExpression level
breastMedium
bronchusMedium
cerebral cortexHigh
cervix, uterineMedium
colonHigh
endometrium 1Medium
endometrium 2High
esophagusHigh
heart muscleMedium
kidneyMedium
liverMedium
lungHigh
nasopharynxMedium
oral mucosaHigh
ovaryHigh
placentaMedium
prostateMedium
skin 1High
skin 2High
smooth muscleMedium
soft tissue 2Medium
thyroid glandMedium
tonsilLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601047, gene) Caveolin 1; CAV1OMIM
2(-606721, phenotype) Lipodystrophy with congenital cataracts and neurodegenerationOMIM
3(#612526, phenotype) Lipodystrophy, congenital generalized, type 3; CGL3OMIM


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