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> Protein (NX_Q04206)
Protein (NX_Q04206)
Protein
Gene SymbolRELA to neXtProt (NX_Q04206)
DescriptionTranscription factor p65
Chromosome11
Location11q13.1 (65421067 ~ 65430565) to Ensembl
Sequene Features : Isoforms 4, Variants 53, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 53 22
2014-09-19protein level
4 39 22
2014-05-27protein level
4 39 22
2014-02-25protein level
4 38 22
2013-12-09protein level
4 33 20
2013-11-01protein level
4 33 20
2013-09-12protein level
4 33 19
2013-08-17protein level
4 33 19
2013-07-15protein level
4 24 19
2013-06-11protein level
4 24 19
2013-02-12protein level
4 9 72
2012-12-20protein level
4 10 72
2012-10-30protein level
4 11 72
2012-10-07protein level
4 11 18
2012-08-24protein level
4 9 15
2012-07-28protein level
4 9 15
2012-06-08protein level
4 5 15
2012-05-07protein level
4 5 15
2012-04-10protein level
4 5 15
2012-01-13protein level
4 5 13
2011-12-20protein level
4 6 13
2011-11-11protein level
4 6 13
2011-08-23protein level
4 6 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q04206-1
0 21 0 60181.2058
NX_Q04206-2
2 19 0 58769.5113
NX_Q04206-3
0 20 0 59030.6904
NX_Q04206-4
1 20 0 59872.0015
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-73886,EBI-9869387 MEN1  
  .maternal process involved in female pregnancy
.palate development
.negative regulation of telomerase activity
  + 37 more...
.R-SMAD binding
.protein N-terminus binding
.transcription regulatory region DNA binding
  + 6 more...
.protein complex
.histone methyltransferase complex
.cleavage furrow
  + 6 more...
2 EBI-73886,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-73886,EBI-539828 OGT  
  .regulation of gluconeogenesis involved in cellular glucose homeostasis
.histone H3-K4 trimethylation
.cellular response to retinoic acid
  + 21 more...
.protein O-GlcNAc transferase activity
.protein N-acetylglucosaminyltransferase activity
.acetylglucosaminyltransferase activity
  + 2 more...
.MLL5-L complex
.plasma membrane
.cytosol
  + 6 more...
4 EBI-73886,EBI-968198 SOCS1  
  .cellular response to amino acid stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.regulation of type I interferon-mediated signaling pathway
  + 13 more...
.protein kinase binding
.kinase inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase inhibitor activity
.cytoplasmic membrane-bounded vesicle
.cytosol
.cytoplasm
.nucleus
5 EBI-73886,EBI-723869 BRD4  
  .negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
6 EBI-73886,EBI-73869 RPS6KA5  
  .interleukin-1-mediated signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 31 more...
.histone kinase activity (H3-S10 specific)
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-73886,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
8 EBI-73886,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
9 EBI-10223388,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
10 EBI-73886,EBI-9844134 ATF3  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.positive regulation of TRAIL-activated apoptotic signaling pathway
.regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
  + 8 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.protein homodimerization activity
  + 8 more...
.CHOP-ATF3 complex
.nucleolus
.nucleoplasm
.nucleus
11 EBI-73886,EBI-300010 NFKB1  
  .positive regulation of miRNA metabolic process
.positive regulation of hyaluronan biosynthetic process
.positive regulation of canonical Wnt signaling pathway
  + 45 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.I-kappaB/NF-kappaB complex
.cytosol
.mitochondrion
  + 3 more...
12 EBI-73886,EBI-727668 TGM2  
  .salivary gland cavitation
.branching involved in salivary gland morphogenesis
.positive regulation of mitochondrial calcium ion concentration
  + 11 more...
.metal ion binding
.GTP binding
.protein-glutamine gamma-glutamyltransferase activity
.extracellular exosome
.intrinsic component of plasma membrane
.focal adhesion
  + 2 more...
13 EBI-73886,EBI-351193 RPS3  
  .positive regulation of apoptotic signaling pathway
.positive regulation of DNA N-glycosylase activity
.cell division
  + 20 more...
.iron-sulfur cluster binding
.NF-kappaB binding
.protein kinase A binding
  + 8 more...
.extracellular exosome
.ruffle membrane
.ribonucleoprotein complex
  + 9 more...
14 EBI-73886,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
15 EBI-73886,EBI-307386 NFKBIA  
  .nucleotide-binding oligomerization domain containing 2 signaling pathway
.nucleotide-binding oligomerization domain containing 1 signaling pathway
.cellular response to cold
  + 39 more...
.NF-kappaB binding
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.plasma membrane
.cytosol
  + 2 more...
16 EBI-73886,EBI-302388 PPP2R1A  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.peptidyl-serine dephosphorylation
.regulation of cell differentiation
  + 24 more...
.protein heterodimerization activity
.protein phosphatase type 2A regulator activity
.protein serine/threonine phosphatase activity
.antigen binding
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 5 more...
17 EBI-73886,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
18 EBI-73886,EBI-518675 STAT3  
  .negative regulation of neuron migration
.interleukin-6-mediated signaling pathway
.JAK-STAT cascade involved in growth hormone signaling pathway
  + 35 more...
.protein dimerization activity
.transcription regulatory region DNA binding
.protein phosphatase binding
  + 9 more...
.plasma membrane
.cytosol
.mitochondrial inner membrane
  + 4 more...
19 EBI-73886,EBI-1748945 IER3  
  .regulation of response to DNA damage stimulus
.regulation of reactive oxygen species metabolic process
.negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 12 more...
.N/A .integral component of membrane
.nucleus
20 EBI-73886,EBI-713543 MAPK10  
  .stress-activated MAPK cascade
.regulation of sequence-specific DNA binding transcription factor activity
.rhythmic process
  + 21 more...
.ATP binding
.MAP kinase kinase activity
.JUN kinase activity
.plasma membrane
.cytosol
.mitochondrion
  + 2 more...
21 EBI-73886,EBI-712311 PPP2CA  
  .positive regulation of protein serine/threonine kinase activity
.protein heterotrimerization
.meiotic cell cycle
  + 25 more...
.metal ion binding
.protein serine/threonine phosphatase activity
.extracellular exosome
.membrane
.microtubule cytoskeleton
  + 7 more...
22 EBI-73886,EBI-357837 RELB  
  .cellular response to osmotic stress
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 12 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.I-kappaB/NF-kappaB complex
.cytosol
.microtubule organizing center
  + 3 more...
23 EBI-10223388,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
24 EBI-73886,EBI-352022 DHX9  
  .CRD-mediated mRNA stabilization
.innate immune response
.cellular response to heat
  + 8 more...
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
  + 4 more...
.CRD-mediated mRNA stability complex
.cytoplasmic ribonucleoprotein granule
.ribonucleoprotein complex
  + 7 more...
25 EBI-73886,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
26 EBI-73886,EBI-3931258 IRF5  
  .type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.defense response to virus
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.cytoplasm
.nucleus
27 EBI-73886,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
28 EBI-73886,EBI-751001 KEAP1  
  .cellular response to interleukin-4
.regulation of epidermal cell differentiation
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.transcription factor binding .Cul3-RING ubiquitin ligase complex
.midbody
.cytosol
  + 4 more...
29 EBI-73886,EBI-352889 NFKBIB  
  .cellular response to lipopolysaccharide
.positive regulation of NF-kappaB transcription factor activity
.innate immune response
  + 15 more...
.signal transducer activity
.transcription coactivator activity
.cytosol
.nucleus
30 EBI-73886,EBI-935824 PDCD4  
  .negative regulation of transcription, DNA-templated
.negative regulation of cell cycle
.negative regulation of JUN kinase activity
  + 2 more...
.RNA binding .cytosol
.cytoplasm
.nucleoplasm
.nucleus
31 EBI-73886,EBI-477232 SIRT2  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
.negative regulation of reactive oxygen species metabolic process
.ripoptosome assembly involved in necroptotic process
  + 55 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
.ubiquitin binding
  + 10 more...
.glial cell projection
.meiotic spindle
.mitotic spindle
  + 21 more...
32 EBI-73886,EBI-1550112 COMMD1  
  .negative regulation of protein localization to cell surface
.negative regulation of sodium ion transmembrane transport
.copper ion homeostasis
  + 7 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidic acid binding
.phosphatidylinositol-3,4-bisphosphate binding
  + 5 more...
.extracellular exosome
.recycling endosome
.Cul2-RING ubiquitin ligase complex
  + 6 more...
33 EBI-73886,EBI-712415 SIRT6  
  .histone H3-K9 deacetylation
.histone H3-K9 modification
.histone deacetylation
  + 2 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H3-K9 specific)
.NAD-dependent histone deacetylase activity
  + 4 more...
.intracellular membrane-bounded organelle
.nucleolus
.nuclear telomeric heterochromatin
  + 2 more...
34 EBI-73886,EBI-1268586 SETD7  
  .heterochromatin organization
.peptidyl-lysine dimethylation
.peptidyl-lysine monomethylation
  + 5 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
35 EBI-73886,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
36 EBI-73886,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
37 EBI-73886,EBI-718818 CDK5RAP3  
  .negative regulation of cellular protein catabolic process
.positive regulation of signal transduction by p53 class mediator
.positive regulation of protein localization to nucleus
  + 13 more...
.MDM2/MDM4 family protein binding
.NF-kappaB binding
.ubiquitin-like protein ligase binding
  + 2 more...
.protein complex
.membrane
.endomembrane system
  + 3 more...
38 EBI-73886,EBI-714994 KLF6  
  .positive regulation of transcription, DNA-templated
.B cell differentiation
.cytokine-mediated signaling pathway
.transcription, DNA-templated
.metal ion binding
.DNA binding
.cytoplasm
.nucleus
39 EBI-73886,EBI-949368 GFI1  
  .cellular response to lipopolysaccharide
.positive regulation of interleukin-6-mediated signaling pathway
.negative regulation of transcription, DNA-templated
  + 15 more...
.transcription regulatory region DNA binding
.zinc ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.transcriptional repressor complex
.nuclear body
.nuclear matrix
.nucleus
40 EBI-73886,EBI-766087 EHMT1  
  .negative regulation of transcription, DNA-templated
.peptidyl-lysine dimethylation
.peptidyl-lysine monomethylation
  + 6 more...
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K9 specific)
.histone-lysine N-methyltransferase activity
  + 4 more...
.plasma membrane
.cytoplasm
.chromosome
  + 2 more...
41 EBI-73886,EBI-372428 AATF  
  .negative regulation of reactive oxygen species metabolic process
.apoptotic signaling pathway
.neurotrophin TRK receptor signaling pathway
  + 10 more...
.poly(A) RNA binding
.leucine zipper domain binding
.sequence-specific DNA binding transcription factor activity
.focal adhesion
.centrosome
.Golgi apparatus
  + 3 more...
42 EBI-73886,EBI-357355 UXT  
  .centrosome organization
.mitochondrion transport along microtubule
.microtubule cytoskeleton organization
.negative regulation of transcription from RNA polymerase II promoter
.beta-tubulin binding
.microtubule binding
.chromatin binding
.RNA polymerase II transcription corepressor activity
.cytoskeleton
.centrosome
.cytoplasm
.nucleus
43 EBI-73886,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland212
ascites200
bladder234
blood220
bone97
bone marrow123
brain193
cervix185
connective tissue187
embryonic tissue103
esophagus99
eye71
heart78
intestine198
kidney175
liver121
lung149
lymph451
lymph node178
mammary gland297
mouth468
muscle103
ovary128
pancreas107
placenta127
prostate253
salivary gland49
skin265
spleen824
stomach188
testis124
thymus815
thyroid107
tonsil117
trachea347
umbilical cord72
uterus189
vascular271
Health State
TissuesTPM*
normal169
bladder carcinoma170
breast (mammary gland) tumor322
cervical tumor144
chondrosarcoma60
colorectal tumor195
esophageal tumor115
gastrointestinal tumor210
germ cell tumor239
glioma242
head and neck tumor224
kidney tumor145
leukemia211
liver tumor124
lung tumor97
lymphoma332
non-neoplasia238
ovarian tumor183
pancreatic tumor133
primitive neuroectodermal tumor of the CNS299
prostate cancer125
retinoblastoma43
skin tumor175
soft tissue/muscle tissue tumor143
uterine tumor144
Developmental Stage
TissuesTPM*
adult144
embryoid body171
blastocyst32
neonate611
fetus150
infant85
juvenile377
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.6
adrenal gland22.8
appendix39.1
bone marrow63
cerebral cortex19.8
colon27.2
duodenum26.9
esophagus39.5
gallbladder39
heart muscle23.1
kidney22.8
liver20.9
lung44.3
lymph node37.6
ovary41.1
pancreas18.7
placenta27.6
prostate31
salivary gland31.9
skin29.9
small intestine27.7
spleen43.9
stomach33.4
testis21.1
thyroid gland26
urinary bladder34.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusLow
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164014, gene) V-rel avian reticuloendotheliosis viral oncogene homolog a; RELAOMIM


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