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> Protein (NX_Q04637)
Protein (NX_Q04637)
Protein
Gene SymbolEIF4G1 to neXtProt (NX_Q04637)
DescriptionEukaryotic translation initiation factor 4 gamma 1
Chromosome3
Location3q27.1 (184032283 ~ 184053146) to Ensembl
Sequene Features : Isoforms 8, Variants 217, PTMs 33 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.cytokine-mediated signaling pathway
.viral process
  + 8 more...
.poly(A) RNA binding
.translation factor activity, RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 4F complex
.membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 217 33
2014-09-19protein level
8 158 33
2014-05-27protein level
8 158 35
2014-02-25protein level
8 156 28
2013-12-09protein level
8 120 28
2013-11-01protein level
8 112 20
2013-09-12protein level
8 112 21
2013-08-17protein level
8 112 21
2013-07-15protein level
5 82 20
2013-06-11protein level
5 82 20
2013-02-12protein level
5 38 100
2012-12-20protein level
5 39 100
2012-10-30protein level
5 45 100
2012-10-07protein level
5 45 20
2012-08-24protein level
5 42 20
2012-07-28protein level
5 42 20
2012-06-08protein level
5 86 20
2012-05-07protein level
5 78 20
2012-04-10protein level
5 78 20
2012-01-13protein level
5 73 20
2011-12-20protein level
5 73 20
2011-11-11protein level
5 72 20
2011-08-23protein level
5 72 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q04637-1
0 56 3 175381.7634
NX_Q04637-3
1 55 3 171406.7756
NX_Q04637-4
1 53 3 166515.3672
NX_Q04637-5
1 52 3 158418.4714
NX_Q04637-6
0 51 3 154708.5028
NX_Q04637-7
0 51 3 154836.561
NX_Q04637-8
0 56 3 175509.8216
NX_Q04637-9
1 56 3 176127.1483
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-73711,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
2 EBI-73711,EBI-366647 EIF3J  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.translation initiation factor activity .eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
.eukaryotic translation initiation factor 3 complex
.cytosol
3 EBI-73711,EBI-73440 EIF4E  
  .positive regulation of mitotic cell cycle
.cellular protein metabolic process
.lung development
  + 11 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA cap binding
.extracellular exosome
.chromatoid body
.RISC complex
  + 6 more...
4 EBI-73711,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
5 EBI-73711,EBI-73449 EIF4A1  
  .cellular protein metabolic process
.organ regeneration
.cytokine-mediated signaling pathway
  + 8 more...
.poly(A) RNA binding
.translation factor activity, RNA binding
.ATP binding
  + 6 more...
.extracellular exosome
.eukaryotic translation initiation factor 4F complex
.membrane
  + 3 more...
6 EBI-73711,EBI-432545 HNRNPD  
  .circadian regulation of translation
.positive regulation of transcription, DNA-templated
.positive regulation of translation
  + 9 more...
.poly(A) RNA binding
.telomeric DNA binding
.RNA binding
.nucleotide binding
.extracellular exosome
.ribonucleoprotein complex
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland151
ascites1004
bladder334
blood171
bone404
bone marrow82
brain169
cervix598
connective tissue207
embryonic tissue375
esophagus99
eye344
heart89
intestine409
kidney204
larynx809
liver165
lung400
lymph586
lymph node289
mammary gland1024
mouth755
muscle263
nerve321
ovary305
pancreas252
parathyroid145
pharynx73
placenta264
prostate437
salivary gland394
skin692
spleen131
stomach167
testis289
thymus125
thyroid364
tonsil235
trachea115
umbilical cord217
uterus267
vascular135
Health State
TissuesTPM*
normal176
adrenal tumor237
bladder carcinoma227
breast (mammary gland) tumor1482
cervical tumor579
chondrosarcoma362
colorectal tumor595
esophageal tumor115
gastrointestinal tumor506
germ cell tumor471
glioma326
head and neck tumor657
kidney tumor246
leukemia243
liver tumor312
lung tumor681
lymphoma457
non-neoplasia175
ovarian tumor262
pancreatic tumor457
primitive neuroectodermal tumor of the CNS322
prostate cancer606
retinoblastoma344
skin tumor1020
soft tissue/muscle tissue tumor287
uterine tumor255
Developmental Stage
TissuesTPM*
adult359
embryoid body500
blastocyst520
neonate354
fetus136
infant42
juvenile431
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue96.2
adrenal gland84.2
appendix79.6
bone marrow76.4
cerebral cortex50.4
colon82.7
duodenum63
esophagus122.6
gallbladder70.9
heart muscle70.7
kidney67.3
liver104.4
lung84.4
lymph node74.8
ovary53.6
pancreas56.8
placenta76.4
prostate82.7
salivary gland85.1
skin135.7
small intestine58.4
spleen68.3
stomach79.8
testis80.7
thyroid gland84.1
urinary bladder74.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600495, gene) Eukaryotic translation initiation factor 4-gamma, 1; EIF4G1OMIM
2(#614251, phenotype) Parkinson disease 18; PARK18OMIM


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