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> Protein (NX_Q04864)
Protein (NX_Q04864)
Protein
Gene SymbolREL to neXtProt (NX_Q04864)
DescriptionProto-oncogene c-Rel
Chromosome2
Location2p16.1 (61108656 ~ 61158745) to Ensembl
Sequene Features : Isoforms 2, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 62 3
2014-09-19protein level
2 46 3
2014-05-27protein level
1 46 3
2014-02-25protein level
1 44 3
2013-12-09protein level
1 36 3
2013-11-01protein level
1 35 3
2013-09-12protein level
1 35 2
2013-08-17protein level
1 35 2
2013-07-15protein level
1 21 2
2013-06-11protein level
1 21 2
2013-02-12protein level
1 11 2
2012-12-20protein level
1 11 2
2012-10-30protein level
1 16 2
2012-10-07protein level
1 16 2
2012-08-24protein level
1 15 2
2012-07-28protein level
1 15 2
2012-06-08protein level
1 17 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 3 2
2011-12-20protein level
1 3 2
2011-11-11protein level
1 3 2
2011-08-23protein level
1 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q04864-1
2 22 0 68476.0069
NX_Q04864-2
1 22 0 65183.395
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307352,EBI-5529694 STRA13  
  .kinetochore assembly
.cell division
.CENP-A containing nucleosome assembly
  + 6 more...
.DNA binding .FANCM-MHF complex
.Fanconi anaemia nuclear complex
.nucleoplasm
.condensed chromosome kinetochore
2 EBI-307352,EBI-473886 HIP1  
  .apoptotic signaling pathway
.clathrin-mediated endocytosis
.clathrin coat assembly
  + 7 more...
.phosphatidylinositol binding
.clathrin binding
.structural constituent of cytoskeleton
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
.clathrin-coated vesicle
  + 5 more...
3 EBI-307352,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
4 EBI-307352,EBI-1237371 ACOT8  
  .small molecule metabolic process
.cellular lipid metabolic process
.dicarboxylic acid catabolic process
  + 8 more...
.medium-chain acyl-CoA hydrolase activity
.carboxylic ester hydrolase activity
.acyl-CoA hydrolase activity
  + 3 more...
.peroxisomal matrix
.mitochondrion
5 EBI-307352,EBI-2339359 HAT1  
  .histone H4 acetylation
.response to nutrient
.internal protein amino acid acetylation
  + 5 more...
.H4 histone acetyltransferase activity
.histone acetyltransferase activity
.protein complex
.intracellular membrane-bounded organelle
.nuclear matrix
  + 4 more...
6 EBI-307352,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
7 EBI-307352,EBI-353818 EIF3D  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 3 more...
8 EBI-307352,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
9 EBI-307352,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
10 EBI-307352,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
11 EBI-307352,EBI-1767898 SEC31A  
  .membrane organization
.response to calcium ion
.COPII vesicle coating
  + 9 more...
.calcium-dependent protein binding .endoplasmic reticulum exit site
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 9 more...
12 EBI-307352,EBI-448202 GADD45G  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
13 EBI-307352,EBI-711158 ARIH2  
  .positive regulation of protein targeting to mitochondrion
.hematopoietic stem cell proliferation
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nucleic acid binding
.cytoplasm
.nucleus
14 EBI-307352,EBI-359472 POLR1A  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 4 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytoplasm
.DNA-directed RNA polymerase I complex
.nucleolus
  + 2 more...
15 EBI-307352,EBI-1054588 EML2  
  .negative regulation of microtubule polymerization
.regulation of microtubule nucleation
.sensory perception of sound
.visual perception
.tubulin binding
.microtubule binding
.microtubule associated complex
.microtubule
.spindle
.cytoplasm
16 EBI-307352,EBI-536866 NUDT14  
  .N/A .ADP-ribose diphosphatase activity
.metal ion binding
.UDP-sugar diphosphatase activity
.extracellular exosome
.cytoplasm
17 EBI-307352,EBI-1220259 DNTT  
  .DNA modification
.DNA metabolic process
.metal ion binding
.DNA nucleotidylexotransferase activity
.DNA-directed DNA polymerase activity
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
18 EBI-307352,EBI-10194851 HLA-DOA  
  .regulation of T cell differentiation
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.signal transduction
  + 2 more...
.MHC class II receptor activity
.MHC class II protein complex binding
.MHC class II protein complex
.integral component of membrane
.endosome membrane
  + 2 more...
19 EBI-307352,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
20 EBI-307352,EBI-9641086 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
21 EBI-307352,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
22 EBI-307352,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
23 EBI-307352,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
24 EBI-307352,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
25 EBI-307352,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
26 EBI-307352,EBI-713992 RABIF  
  .membrane fusion
.positive regulation of GTPase activity
.protein transport
.small GTPase mediated signal transduction
.zinc ion binding
.guanyl-nucleotide exchange factor activity
.N/A
27 EBI-307352,EBI-3843589 SLC6A12  
  .cellular hyperosmotic response
.transmembrane transport
.response to organic substance
  + 6 more...
.gamma-aminobutyric acid:sodium symporter activity
.neurotransmitter:sodium symporter activity
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
28 EBI-307352,EBI-741925 DHPS  
  .protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
29 EBI-307352,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
30 EBI-307352,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
31 EBI-307352,EBI-713847 POLE2  
  .error-prone translesion synthesis
.telomere maintenance via semi-conservative replication
.nucleotide-excision repair, DNA gap filling
  + 10 more...
.DNA-directed DNA polymerase activity
.DNA binding
.intracellular membrane-bounded organelle
.epsilon DNA polymerase complex
.nucleoplasm
32 EBI-307352,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
33 EBI-307352,EBI-10215880 MAP3K7CL  
  .N/A .N/A .cytosol
.nucleus
34 EBI-307352,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
35 EBI-307352,EBI-473850 UBE2K  
  .protein K48-linked ubiquitination
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin protein ligase activity
.ubiquitin-ubiquitin ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.intermediate filament cytoskeleton
.actin cytoskeleton
  + 2 more...
36 EBI-307352,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
37 EBI-307352,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
38 EBI-307352,EBI-373150 EIF5A  
  .positive regulation of translational termination
.positive regulation of translational elongation
.cellular protein metabolic process
  + 8 more...
.protein N-terminus binding
.poly(A) RNA binding
.ribosome binding
  + 3 more...
.extracellular exosome
.membrane
.cytosol
  + 5 more...
39 EBI-307352,EBI-6693977 FKBP1B  
  .cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
40 EBI-307352,EBI-4481939 FOXO4  
  .negative regulation of G0 to G1 transition
.negative regulation of smooth muscle cell differentiation
.stem cell differentiation
  + 16 more...
.sequence-specific DNA binding
.enzyme binding
.transcription factor binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
41 EBI-307352,EBI-307326 NFKB2  
  .positive regulation of NF-kappaB transcription factor activity
.spleen development
.rhythmic process
  + 25 more...
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.Bcl3/NF-kappaB2 complex
.cytosol
.cytoplasm
  + 2 more...
42 EBI-307352,EBI-1054396 OTUD4  
  .protein K48-linked deubiquitination .poly(A) RNA binding
.ubiquitin-specific protease activity
.N/A
43 EBI-307352,EBI-10223388 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
44 EBI-307352,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
45 EBI-307352,EBI-10226430 RIPPLY1  
  .bone morphogenesis
.negative regulation of transcription, DNA-templated
.somite rostral/caudal axis specification
  + 4 more...
.N/A .nucleus
46 EBI-307352,EBI-347859 CPSF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 6 more...
.mRNA 3'-UTR binding .mRNA cleavage and polyadenylation specificity factor complex
.nucleoplasm
47 EBI-307352,EBI-1020839 CHAF1A  
  .chromatin assembly
.cell cycle
.protein complex assembly
  + 3 more...
.chromo shadow domain binding
.unfolded protein binding
.identical protein binding
.chromatin binding
.protein complex
.CAF-1 complex
.nuclear chromatin
48 EBI-307352,EBI-74090 EIF4EBP1  
  .negative regulation of translational initiation
.positive regulation of mitotic cell cycle
.response to ethanol
  + 11 more...
.translation repressor activity
.eukaryotic initiation factor 4E binding
.protein complex
.cytosol
.cytoplasm
.nucleoplasm
49 EBI-307352,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
50 EBI-307352,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
51 EBI-307352,EBI-6654703 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
52 EBI-307352,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
53 EBI-307352,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
54 EBI-307352,EBI-998637 PLCB4  
  .small molecule metabolic process
.inositol phosphate metabolic process
.intracellular signal transduction
.lipid catabolic process
.calcium ion binding
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.dendrite
.postsynaptic density
.cytosol
  + 2 more...
55 EBI-307352,EBI-10176094 SEPT7  
  .cilium morphogenesis
.protein heterooligomerization
.regulation of embryonic cell shape
  + 2 more...
.identical protein binding
.GTP binding
.structural molecule activity
.extracellular exosome
.synapse
.axon terminus
  + 13 more...
56 EBI-307352,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
57 EBI-307352,EBI-2907712 FUT11  
  .protein glycosylation .alpha-(1->3)-fucosyltransferase activity .extracellular exosome
.Golgi cisterna membrane
.integral component of membrane
58 EBI-307352,EBI-10244509 RAB41  
  .retrograde transport, endosome to Golgi
.Rab protein signal transduction
.metabolic process
  + 3 more...
.GTP binding
.GTPase activity
.Golgi apparatus
59 EBI-307352,EBI-743105 EFHC1  
  .cerebral cortex cell migration .protein C-terminus binding
.calcium ion binding
.mitotic spindle
.neuronal cell body
.axoneme
.centrosome
60 EBI-307352,EBI-1055462 NOL9  
  .maturation of 5.8S rRNA
.cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.polynucleotide 5'-hydroxyl-kinase activity
.ATP binding
.RNA binding
.membrane
.nucleolus
61 EBI-307352,EBI-10245139 SZT2  
  .regulation of superoxide dismutase activity
.pigmentation
.corpus callosum morphogenesis
  + 2 more...
.N/A .extracellular exosome
.peroxisome
62 EBI-307352,EBI-8994397 TSTD2  
  .N/A .N/A .N/A
63 EBI-307352,EBI-10248548 RNF213  
  .protein autoubiquitination
.protein ubiquitination
.ATPase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.nucleolus
64 EBI-307352,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
65 EBI-307352,EBI-948354 TTC19  
  .mitochondrial respiratory chain complex III assembly
.cytokinesis
.N/A .midbody
.centrosome
.mitochondrial inner membrane
.mitochondrion
66 EBI-307352,EBI-10254561 ZDHHC24  
  .N/A .protein-cysteine S-palmitoyltransferase activity
.zinc ion binding
.integral component of membrane
67 EBI-307352,EBI-9676069 ZNF765  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
68 EBI-307352,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
69 EBI-307352,EBI-10256834 ZNF550  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
70 EBI-307352,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
71 EBI-307352,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
72 EBI-307352,EBI-723524 MRPL10  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.poly(A) RNA binding
.structural constituent of ribosome
.ribonucleoprotein complex
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
  + 2 more...
73 EBI-307352,EBI-10259086 TRIM74  
  .N/A .zinc ion binding .intracellular
74 EBI-307352,EBI-10260040 NR2C2AP  
  .gene expression
.transcription initiation from RNA polymerase II promoter
.N/A .extracellular exosome
.nucleoplasm
75 EBI-307352,EBI-748515 GLYCTK  
  .protein phosphorylation .glycerate kinase activity
.ATP binding
.mitochondrion
.cytoplasm
76 EBI-307352,EBI-10262361 REXO1L1P  
  .N/A .exonuclease activity
.nucleic acid binding
.cytoplasm
.nucleus
77 EBI-307352,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
78 EBI-307352,EBI-1550112 COMMD1  
  .negative regulation of protein localization to cell surface
.negative regulation of sodium ion transmembrane transport
.copper ion homeostasis
  + 7 more...
.phosphatidylinositol-3,5-bisphosphate binding
.phosphatidic acid binding
.phosphatidylinositol-3,4-bisphosphate binding
  + 5 more...
.extracellular exosome
.recycling endosome
.Cul2-RING ubiquitin ligase complex
  + 6 more...
79 EBI-307352,EBI-742815 FLAD1  
  .small molecule metabolic process
.riboflavin metabolic process
.water-soluble vitamin metabolic process
  + 2 more...
.ATP binding
.FMN adenylyltransferase activity
.plasma membrane
.cytosol
.mitochondrial matrix
.cytoplasm
80 EBI-307352,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
81 EBI-307352,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
82 EBI-307352,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
83 EBI-307352,EBI-2609717 ASAP3  
  .regulation of stress fiber assembly
.positive regulation of GTPase activity
.cell migration
.zinc ion binding
.GTPase activator activity
.focal adhesion
.cytoplasm
.ruffle
84 EBI-307352,EBI-10276431 HDAC7  
  .positive regulation of cell migration involved in sprouting angiogenesis
.negative regulation of osteoblast differentiation
.cellular protein metabolic process
  + 8 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.14-3-3 protein binding
.repressing transcription factor binding
  + 9 more...
.cytoplasm
.nucleoplasm
.nucleus
.histone deacetylase complex
85 EBI-307352,EBI-10232538 PIH1D2  
  .N/A .Ral GTPase binding .N/A
86 EBI-307352,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
87 EBI-307352,EBI-10277790 PATE1  
  .N/A .N/A .extracellular region
88 EBI-307352,EBI-1051152 OSTF1  
  .signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
89 EBI-307352,EBI-366525 POP5  
  .tRNA processing .ribonuclease P activity .nucleolar ribonuclease P complex
90 EBI-307352,EBI-10281234 NEIL2  
  .depyrimidination
.nucleotide-excision repair
.base-excision repair, AP site formation
  + 2 more...
.hydrolase activity, hydrolyzing N-glycosyl compounds
.zinc ion binding
.DNA-(apurinic or apyrimidinic site) lyase activity
.damaged DNA binding
.spindle microtubule
.cytoplasm
.nucleoplasm
91 EBI-307352,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
92 EBI-307352,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
93 EBI-307352,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
94 EBI-307352,EBI-7097057 CPNE2  
  .N/A .N/A .extracellular exosome
95 EBI-307352,EBI-7225508 SLC41A3  
  .N/A .cation transmembrane transporter activity .integral component of membrane
.plasma membrane
96 EBI-307352,EBI-10287091 SLC39A13  
  .zinc II ion transmembrane transport
.connective tissue development
.cellular zinc ion homeostasis
.protein homodimerization activity
.zinc ion transmembrane transporter activity
.perinuclear region of cytoplasm
.integral component of Golgi membrane
.integral component of membrane
.Golgi apparatus
97 EBI-307352,EBI-3919268 BMF  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of apoptotic signaling pathway
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 6 more...
.N/A .myosin complex
.plasma membrane
.cytosol
  + 2 more...
98 EBI-307352,EBI-741885 CEP19  
  .N/A .N/A .ciliary basal body
.centriole
.spindle pole
99 EBI-307352,EBI-2961725 C9orf72  
  .autophagy
.endocytosis
.Rab GTPase binding .intercellular bridge
.cytoplasmic vesicle
.actin cytoskeleton
  + 7 more...
100 EBI-307352,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
101 EBI-307352,EBI-10292696 CIB3  
  .N/A .calcium ion binding .N/A
102 EBI-307352,EBI-741945 VPS25  
  .membrane organization
.protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.endosomal transport
  + 2 more...
.protein N-terminus binding
.protein homodimerization activity
.structural molecule activity
.extracellular exosome
.endosome membrane
.cytosol
  + 6 more...
103 EBI-307352,EBI-6137472 MIEN1  
  .positive regulation of filopodium assembly
.cell redox homeostasis
.negative regulation of apoptotic process
  + 2 more...
.selenium binding .extracellular exosome
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
  + 2 more...
104 EBI-307352,EBI-10298649 NDUFAF3  
  .mitochondrial respiratory chain complex I assembly .N/A .mitochondrial inner membrane
.nucleus
105 EBI-307352,EBI-9675976 SNRNP25  
  .RNA splicing
.mRNA processing
.N/A .intercellular bridge
.cytoplasm
.U12-type spliceosomal complex
  + 2 more...
106 EBI-307352,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
107 EBI-307352,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
108 EBI-307352,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
109 EBI-307352,EBI-748028 EIF5A2  
  .mRNA transport
.positive regulation of translational termination
.positive regulation of translational elongation
  + 8 more...
.ribosome binding
.translation elongation factor activity
.cytosol
.endoplasmic reticulum membrane
.nuclear pore
110 EBI-307352,EBI-721765 C11orf68  
  .N/A .poly(A) RNA binding .N/A
111 EBI-307352,EBI-1175354 EGLN3  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of neuron apoptotic process
  + 7 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.iron ion binding
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
112 EBI-307352,EBI-720977 UBE2Z  
  .apoptotic process
.protein polyubiquitination
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 2 more...
.cytoplasm
.nucleoplasm
113 EBI-307352,EBI-3921217 PARVG  
  .actin cytoskeleton reorganization
.cell-matrix adhesion
.actin binding .focal adhesion
.plasma membrane
.cytoskeleton
.cytoplasm
114 EBI-307352,EBI-10310808 TMEM8A  
  .cell adhesion .N/A .extracellular exosome
.integral component of plasma membrane
.plasma membrane
.lysosomal membrane
115 EBI-307352,EBI-10311131 CABP5  
  .signal transduction .calcium ion binding .cytosol
116 EBI-307352,EBI-10311409 NGB  
  .oxygen transport
.apoptotic process
.heme binding
.iron ion binding
.oxygen transporter activity
.perikaryon
.mitochondrion
117 EBI-307352,EBI-752122 NXT2  
  .mRNA transport
.protein transport
.N/A .cytoplasm
.nucleus
118 EBI-307352,EBI-2809489 A1CF  
  .protein stabilization
.mRNA modification
.cytidine to uridine editing
  + 2 more...
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.apolipoprotein B mRNA editing enzyme complex
.endoplasmic reticulum
.cytoplasm
.nucleoplasm
119 EBI-307352,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
120 EBI-307352,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
121 EBI-307352,EBI-10312448 PRDM10  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleus
122 EBI-307352,EBI-1754287 AGPAT4  
  .glycerophospholipid biosynthetic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 5 more...
.1-acylglycerol-3-phosphate O-acyltransferase activity .integral component of membrane
.endoplasmic reticulum membrane
123 EBI-307352,EBI-747082 CTNNBIP1  
  .negative regulation of mesenchymal cell proliferation
.negative regulation of transcription initiation from RNA polymerase II promoter
.negative regulation of smooth muscle cell proliferation
  + 10 more...
.armadillo repeat domain binding
.beta-catenin binding
.beta-catenin destruction complex
.cytosol
.cytoplasm
  + 2 more...
124 EBI-307352,EBI-10309345 TXNL4B  
  .mitotic nuclear division
.spliceosomal complex assembly
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
125 EBI-307352,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
126 EBI-307352,EBI-10316571 BARHL2  
  .positive regulation of translation
.regulation of axon extension
.neuron differentiation
  + 2 more...
.sequence-specific DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.cytoplasm
.nucleoplasm
127 EBI-307352,EBI-10318410 COL20A1  
  .extracellular matrix organization .N/A .endoplasmic reticulum lumen
.extracellular space
.collagen trimer
.extracellular region
128 EBI-307352,EBI-465156 IL36RN  
  .negative regulation of interferon-gamma secretion
.innate immune response
.negative regulation of interleukin-6 production
  + 4 more...
.interleukin-1 receptor antagonist activity
.interleukin-1 receptor binding
.cytokine activity
.extracellular space
129 EBI-307352,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
130 EBI-307352,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
131 EBI-307352,EBI-10320311 SEC14L4  
  .N/A .lipid binding
.transporter activity
.integral component of membrane
.intracellular
132 EBI-307352,EBI-723153 CGGBP1  
  .negative regulation of transcription from RNA polymerase II promoter .double-stranded DNA binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
133 EBI-307352,EBI-748350 RTDR1  
  .N/A .N/A .N/A
134 EBI-307352,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
135 EBI-307352,EBI-2805360 LNPEP  
  .membrane organization
.SMAD protein signal transduction
.antigen processing and presentation of exogenous peptide antigen via MHC class I
  + 7 more...
.zinc ion binding
.metallopeptidase activity
.aminopeptidase activity
.perinuclear region of cytoplasm
.early endosome lumen
.cytoplasmic vesicle membrane
  + 7 more...
136 EBI-307352,EBI-372578 NAGK  
  .carbohydrate phosphorylation
.N-acetylneuraminate catabolic process
.N-acetylmannosamine metabolic process
.N-acetylglucosamine metabolic process
.N-acetylglucosamine kinase activity
.N-acylmannosamine kinase activity
.ATP binding
.extracellular exosome
137 EBI-307352,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
138 EBI-307352,EBI-747601 TRAPPC2L  
  .ER to Golgi vesicle-mediated transport .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.cytoplasm
139 EBI-307352,EBI-10281601 OAZ3  
  .negative regulation of polyamine transmembrane transport
.positive regulation of protein catabolic process
.small molecule metabolic process
  + 6 more...
.putrescine transmembrane transporter activity
.ornithine decarboxylase inhibitor activity
.blood microparticle
.sperm flagellum
.cytosol
.nucleus
140 EBI-307352,EBI-10326419 R3HDM2  
  .N/A .poly(A) RNA binding .nucleus
141 EBI-307352,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
142 EBI-307352,EBI-347416 LSM2  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.Ral GTPase binding
.U6 snRNA binding
.catalytic step 2 spliceosome
.cytosol
.nucleoplasm
143 EBI-307352,EBI-371892 EXOSC1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA binding .cytosol
.cytoplasm
.nucleolus
  + 4 more...
144 EBI-307352,EBI-10328570 NEUROG3  
  .transdifferentiation
.positive regulation of sequence-specific DNA binding transcription factor activity
.regulation of dendrite morphogenesis
  + 11 more...
.chromatin DNA binding
.transcription coactivator activity
.double-stranded DNA binding
  + 4 more...
.cytoplasm
.nucleus
145 EBI-307352,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
146 EBI-307352,EBI-717229 TSSC4  
  .N/A .N/A .N/A
147 EBI-307352,EBI-2556107 DYNC1LI1  
  .positive regulation of mitotic cell cycle spindle assembly checkpoint
.cell division
.viral process
  + 3 more...
.poly(A) RNA binding
.ATP binding
.microtubule motor activity
.membrane
.plasma membrane
.microtubule
  + 6 more...
148 EBI-307352,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood49
brain1
cervix20
embryonic tissue4
intestine21
kidney9
larynx42
liver9
lung8
lymph45
lymph node89
mammary gland13
mouth15
placenta7
thymus12
thyroid21
trachea38
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor10
cervical tumor28
colorectal tumor8
head and neck tumor22
leukemia52
liver tumor20
lymphoma27
ovarian tumor26
prostate cancer9
uterine tumor11
Developmental Stage
TissuesTPM*
adult3
embryoid body14
blastocyst16
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4
adrenal gland4.3
appendix16.5
bone marrow23.2
cerebral cortex2
colon5.5
duodenum4.2
esophagus7.9
gallbladder11.1
heart muscle1.7
kidney3.1
liver5.9
lung6.1
lymph node15.8
ovary5.1
pancreas2.8
placenta5.3
prostate3.2
salivary gland3
skin5.4
small intestine4.8
spleen9.9
stomach5.7
testis4
thyroid gland4.8
urinary bladder14.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164910, gene) V-rel avian reticuloendotheliosis viral oncogene homolog; RELOMIM
2Hodgkin LymphomaCGP


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