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> Protein (NX_Q04917)
Protein (NX_Q04917)
Protein
Gene SymbolYWHAH to neXtProt (NX_Q04917)
Description14-3-3 protein eta
Chromosome22
Location22q12.3 (32340447 ~ 32353590) to Ensembl
Sequene Features : Isoforms 1, Variants 17, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 17 7
2014-09-19protein level
1 12 7
2014-05-27protein level
1 12 13
2014-02-25protein level
1 12 13
2013-12-09protein level
1 9 13
2013-11-01protein level
1 9 6
2013-09-12protein level
1 9 7
2013-08-17protein level
1 9 7
2013-07-15protein level
1 4 7
2013-06-11protein level
1 4 7
2013-02-12protein level
1 3 5
2012-12-20protein level
1 3 5
2012-10-30protein level
1 2 5
2012-10-07protein level
1 2 5
2012-08-24protein level
1 2 5
2012-07-28protein level
1 2 5
2012-06-08protein level
1 6 5
2012-05-07protein level
1 8 5
2012-04-10protein level
1 8 5
2012-01-13protein level
1 5 5
2011-12-20protein level
1 5 5
2011-11-11protein level
1 5 4
2011-08-23protein level
1 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q04917-1
11 0 3 28200.9395
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-306940,EBI-944395 GREM1  
  .positive regulation of cardiac muscle cell differentiation
.positive regulation of receptor activity
.negative regulation of bone mineralization involved in bone maturation
  + 39 more...
.receptor agonist activity
.vascular endothelial growth factor receptor 2 binding
.BMP binding
  + 2 more...
.cell surface
.extracellular space
2 EBI-306940,EBI-1043945 CDK14  
  .regulation of canonical Wnt signaling pathway
.regulation of cell cycle
.cell division
  + 2 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.plasma membrane
.cytosol
.cytoplasm
  + 2 more...
3 EBI-306940,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-306940,EBI-707595 MARK3  
  .N/A .ATP binding
.protein serine/threonine kinase activity
.extracellular exosome
.plasma membrane
5 EBI-306940,EBI-1051746 CDC25B  
  .cell division
.positive regulation of mitotic cell cycle
.positive regulation of protein kinase activity
  + 9 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.cytosol
.centrosome
.cytoplasm
  + 2 more...
6 EBI-306940,EBI-9684465 SNCA  
  .regulation of reactive oxygen species biosynthetic process
.regulation of synaptic vesicle recycling
.positive regulation of hydrogen peroxide catabolic process
  + 63 more...
.phosphoprotein binding
.tau protein binding
.dynein binding
  + 14 more...
.perinuclear region of cytoplasm
.fibril
.terminal bouton
  + 21 more...
7 EBI-306940,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
8 EBI-306940,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
9 EBI-306940,EBI-6173812 KANK1  
  .negative regulation of lamellipodium morphogenesis
.regulation of establishment of cell polarity
.negative regulation of ruffle assembly
  + 11 more...
.beta-catenin binding .ruffle membrane
.cytoplasm
.nucleus
10 EBI-306940,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
11 EBI-306940,EBI-516560 MARK2  
  .mitochondrion localization
.regulation of cytoskeleton organization
.regulation of axonogenesis
  + 11 more...
.tau-protein kinase activity
.poly(A) RNA binding
.protein kinase activator activity
  + 4 more...
.microtubule bundle
.basal cortex
.lateral plasma membrane
  + 5 more...
12 EBI-306940,EBI-6424030 CAMKK1  
  .synaptic transmission .ATP binding
.calmodulin-dependent protein kinase activity
.cytosol
.nucleus
13 EBI-306940,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
14 EBI-306940,EBI-720593 AKT1S1  
  .regulation of cellular response to heat
.phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
  + 9 more...
.N/A .protein complex
.cytosol
.cytoplasm
.nucleoplasm
15 EBI-306940,EBI-302319 MARK4  
  .positive regulation of programmed cell death
.nervous system development
.organelle organization
  + 3 more...
.tau-protein kinase activity
.ubiquitin binding
.gamma-tubulin binding
  + 3 more...
.neuron projection
.ciliary basal body
.microtubule cytoskeleton
  + 3 more...
16 EBI-306940,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
17 EBI-306940,EBI-295391 PARD6B  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 7 more...
.N/A .extracellular exosome
.apical part of cell
.protein complex
  + 6 more...
18 EBI-306940,EBI-81876 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland212
ascites175
bladder167
blood261
bone167
bone marrow41
brain241
cervix103
connective tissue87
ear124
embryonic tissue136
esophagus49
eye86
heart156
intestine112
kidney75
larynx42
liver82
lung71
lymph45
lymph node44
mammary gland145
mouth166
muscle56
nerve128
ovary29
pancreas402
parathyroid48
pharynx73
pituitary gland121
placenta208
prostate42
salivary gland98
skin109
stomach146
testis43
thymus25
thyroid85
tonsil117
umbilical cord72
uterus206
vascular77
Health State
TissuesTPM*
normal132
adrenal tumor395
bladder carcinoma227
breast (mammary gland) tumor128
cervical tumor115
chondrosarcoma193
colorectal tumor142
esophageal tumor57
gastrointestinal tumor143
germ cell tumor106
glioma130
head and neck tumor119
kidney tumor116
leukemia338
liver tumor83
lung tumor29
lymphoma221
non-neoplasia31
ovarian tumor13
pancreatic tumor780
primitive neuroectodermal tumor of the CNS338
prostate cancer48
retinoblastoma86
skin tumor39
soft tissue/muscle tissue tumor223
uterine tumor144
Developmental Stage
TissuesTPM*
adult136
embryoid body142
blastocyst65
neonate32
fetus262
infant42
juvenile395
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue72.2
adrenal gland82.1
appendix81.9
bone marrow63.8
cerebral cortex422
colon91.1
duodenum53.1
esophagus58.8
gallbladder91.9
heart muscle51.1
kidney44.8
liver36.6
lung94.3
lymph node64.9
ovary39.9
pancreas28.4
placenta74.6
prostate45.5
salivary gland29.1
skin34.6
small intestine60
spleen52.5
stomach98.3
testis18.9
thyroid gland44.6
urinary bladder84.6
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineLow
colonMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
nasopharynxMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 1Medium
soft tissue 2Low
spleenLow
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*113508, gene) Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,OMIM


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