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> Protein (NX_Q04941)
Protein (NX_Q04941)
Protein
Gene SymbolPLP2 to neXtProt (NX_Q04941)
DescriptionProteolipid protein 2
ChromosomeX
LocationXp11.23 (49028273 ~ 49031588) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ion transmembrane transport
.cytokine-mediated signaling pathway
.chemotaxis
.ion transport
.chemokine binding
.ion transmembrane transporter activity
.extracellular exosome
.integral component of membrane
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 4
2014-09-19protein level
2 26 4
2014-05-27protein level
2 26 4
2014-02-25protein level
2 26 4
2013-12-09protein level
2 23 4
2013-11-01protein level
2 23 4
2013-09-12protein level
2 23 4
2013-08-17protein level
2 23 4
2013-07-15protein level
2 14 2
2013-06-11protein level
2 14 2
2013-02-12protein level
2 6 4
2012-12-20protein level
2 5 4
2012-10-30protein level
2 6 4
2012-10-07protein level
2 6 2
2012-08-24protein level
2 6 2
2012-07-28protein level
2 6 2
2012-06-08protein level
2 6 2
2012-05-07protein level
2 6 2
2012-04-10protein level
2 6 2
2012-01-13protein level
2 3 2
2011-12-20protein level
2 3 2
2011-11-11protein level
2 3 2
2011-08-23protein level
2 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q04941-1
2 4 0 16679.6484
NX_Q04941-2
1 4 0 15935.5308
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-608347,EBI-608322 CCR1  
  .positive regulation of monocyte chemotaxis
.positive regulation of ERK1 and ERK2 cascade
.chemokine-mediated signaling pathway
  + 20 more...
.chemokine (C-C motif) ligand 5 binding
.chemokine (C-C motif) ligand 7 binding
.C-C chemokine binding
  + 3 more...
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
2 EBI-608347,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
3 EBI-608347,EBI-8649725 TMEM79  
  .cornification
.establishment of skin barrier
.positive regulation of epidermis development
  + 4 more...
.N/A .trans-Golgi network membrane
.integral component of membrane
.lysosomal membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
ascites150
bladder33
blood147
bone307
bone marrow123
brain21
cervix391
connective tissue60
embryonic tissue14
esophagus99
eye67
heart55
intestine159
kidney71
larynx255
liver24
lung185
lymph22
lymph node66
mammary gland171
mouth120
muscle37
ovary226
pancreas154
pharynx98
pituitary gland60
placenta10
prostate63
salivary gland197
skin151
spleen56
stomach1128
testis22
thymus25
thyroid21
tonsil58
trachea19
uterus120
vascular77
Health State
TissuesTPM*
normal39
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor236
cervical tumor434
chondrosarcoma205
colorectal tumor177
esophageal tumor115
gastrointestinal tumor911
germ cell tumor3
glioma111
head and neck tumor134
kidney tumor130
leukemia190
liver tumor20
lung tumor330
lymphoma27
non-neoplasia103
ovarian tumor288
pancreatic tumor295
primitive neuroectodermal tumor of the CNS78
prostate cancer96
retinoblastoma21
skin tumor175
soft tissue/muscle tissue tumor31
uterine tumor122
Developmental Stage
TissuesTPM*
adult164
embryoid body42
fetus39
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue48.1
adrenal gland100.6
appendix73.9
bone marrow172.1
cerebral cortex6.8
colon112.9
duodenum52
esophagus215.2
gallbladder47
heart muscle49.2
kidney16.1
liver7.9
lung68.4
lymph node47.7
ovary71.1
pancreas43.2
placenta49.6
prostate47.1
salivary gland34.7
skin282.3
small intestine68.3
spleen32.1
stomach73.4
testis21.7
thyroid gland17
urinary bladder101.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300112, gene) Proteolipid protein 2; PLP2OMIM


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