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> Protein (NX_Q05084)
Protein (NX_Q05084)
Protein
Gene SymbolICA1 to neXtProt (NX_Q05084)
DescriptionIslet cell autoantigen 1
Chromosome7
Location7p21.3 (8152814 ~ 8302317) to Ensembl
Sequene Features : Isoforms 3, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neurotransmitter transport .N/A .synaptic vesicle membrane
.secretory granule membrane
.transport vesicle membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 72 0
2014-09-19protein level
3 53 0
2014-05-27protein level
2 53 0
2014-02-25protein level
2 51 0
2013-12-09protein level
2 40 0
2013-11-01protein level
2 36 0
2013-09-12protein level
2 36 0
2013-08-17protein level
1 36 0
2013-07-15protein level
1 25 0
2013-06-11protein level
1 25 0
2013-02-12protein level
1 9 0
2012-12-20protein level
1 9 0
2012-10-30protein level
1 10 0
2012-10-07protein level
1 10 0
2012-08-24protein level
1 7 0
2012-07-28protein level
1 7 0
2012-06-08protein level
1 9 0
2012-05-07protein level
1 9 0
2012-04-10protein level
1 9 0
2012-01-13protein level
1 6 0
2011-12-20protein level
1 6 0
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05084-1
0 21 1 54610.0717
NX_Q05084-2
2 20 1 57884.7499
NX_Q05084-3
1 20 1 54523.0399
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1046751,EBI-1783068 MBD3  
  .ATP-dependent chromatin remodeling
.histone acetylation
.tissue development
  + 5 more...
.methyl-CpG binding
.chromatin binding
.DNA binding
.protein complex
.NuRD complex
.cytoplasm
  + 3 more...
2 EBI-1046751,EBI-752037 RAB2A  
  .Rab protein signal transduction
.metabolic process
.Golgi organization
  + 3 more...
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.melanosome
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 4 more...
3 EBI-1046751,EBI-355471 CCDC28A  
  .N/A .N/A .N/A
4 EBI-1046751,EBI-5542466 RAB2B  
  .positive regulation of exocytosis
.Rab protein signal transduction
.vesicle-mediated transport
  + 2 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.endoplasmic reticulum membrane
.Golgi membrane
5 EBI-1046751,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites125
bladder33
blood40
bone13
bone marrow20
brain30
cervix20
connective tissue13
embryonic tissue23
eye19
heart78
intestine99
kidney14
liver14
lung38
lymph node33
mammary gland33
muscle9
nerve64
ovary19
pancreas74
parathyroid97
pharynx24
placenta14
prostate42
salivary gland49
skin9
spleen18
testis39
thyroid85
trachea57
uterus21
vascular19
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor21
cervical tumor28
colorectal tumor115
gastrointestinal tumor42
germ cell tumor15
glioma9
head and neck tumor14
leukemia52
liver tumor10
lung tumor29
non-neoplasia51
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS125
prostate cancer48
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult41
embryoid body14
blastocyst16
fetus21
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.3
adrenal gland13.2
appendix13.7
bone marrow22.4
cerebral cortex18.6
colon28
duodenum19
esophagus14.1
gallbladder22.2
heart muscle41.1
kidney15.7
liver4.4
lung19.4
lymph node14.9
ovary2
pancreas27.1
placenta10.5
prostate27.6
salivary gland28.9
skin31
small intestine25.4
spleen13.8
stomach42.5
testis46.9
thyroid gland18.3
urinary bladder23.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147625, gene) Islet cell autoantigen 1; ICA1OMIM


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