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> Protein (NX_Q05086)
Protein (NX_Q05086)
Protein
Gene SymbolUBE3A to neXtProt (NX_Q05086)
DescriptionUbiquitin-protein ligase E3A
Chromosome15
Location15q11.2 (25582381 ~ 25684128) to Ensembl
Sequene Features : Isoforms 3, Variants 113, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein K48-linked ubiquitination
.prostate gland growth
  + 13 more...
.ubiquitin protein ligase activity
.metal ion binding
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleus
.proteasome complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 113 22
2014-09-19protein level
3 92 22
2014-05-27protein level
3 92 22
2014-02-25protein level
3 92 22
2013-12-09protein level
3 82 22
2013-11-01protein level
3 80 15
2013-09-12protein level
3 80 15
2013-08-17protein level
3 80 15
2013-07-15protein level
3 52 2
2013-06-11protein level
3 52 2
2013-02-12protein level
3 18 6
2012-12-20protein level
3 18 6
2012-10-30protein level
3 19 6
2012-10-07protein level
3 19 2
2012-08-24protein level
3 11 2
2012-07-28protein level
3 11 2
2012-06-08protein level
3 16 2
2012-05-07protein level
3 15 2
2012-04-10protein level
3 15 2
2012-01-13protein level
3 20 2
2011-12-20protein level
3 20 2
2011-11-11protein level
3 20 2
2011-08-23protein level
3 20 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05086-1
0 42 0 100623.0904
NX_Q05086-2
0 41 0 97904.8811
NX_Q05086-3
0 42 0 100037.833
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-954357,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-10175863,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
3 EBI-10175863,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
4 EBI-10175863,EBI-2609717 ASAP3  
  .regulation of stress fiber assembly
.positive regulation of GTPase activity
.cell migration
.zinc ion binding
.GTPase activator activity
.focal adhesion
.cytoplasm
.ruffle
5 EBI-10175863,EBI-720250 AHSP  
  .protein stabilization
.hemopoiesis
.hemoglobin metabolic process
.protein folding
.unfolded protein binding
.hemoglobin binding
.hemoglobin complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites150
bladder167
blood8
bone83
bone marrow20
brain74
cervix123
connective tissue187
ear186
embryonic tissue89
eye47
heart122
intestine64
kidney109
larynx340
liver77
lung104
lymph293
lymph node300
mammary gland105
mouth136
muscle141
nerve193
ovary39
pancreas70
parathyroid97
pharynx49
pituitary gland60
placenta98
prostate205
salivary gland49
skin47
spleen37
stomach41
testis89
thymus37
thyroid85
uterus94
vascular135
Health State
TissuesTPM*
normal97
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma72
colorectal tumor53
gastrointestinal tumor84
germ cell tumor121
glioma102
head and neck tumor141
kidney tumor72
leukemia42
liver tumor93
lung tumor87
lymphoma207
non-neoplasia124
ovarian tumor26
pancreatic tumor47
primitive neuroectodermal tumor of the CNS31
prostate cancer173
retinoblastoma43
skin tumor39
soft tissue/muscle tissue tumor191
uterine tumor66
Developmental Stage
TissuesTPM*
adult117
embryoid body128
blastocyst81
fetus109
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.8
adrenal gland28.2
appendix25.5
bone marrow12.4
cerebral cortex31.2
colon24.5
duodenum19.7
esophagus29.1
gallbladder23.7
heart muscle28.9
kidney25.2
liver18.2
lung19.2
lymph node28.6
ovary29.7
pancreas10.8
placenta20.7
prostate26.5
salivary gland15.5
skin22.2
small intestine22.4
spleen20.2
stomach20.9
testis36.1
thyroid gland36.3
urinary bladder27.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#105830, phenotype) Angelman syndrome; ASOMIM
2(*601623, gene) Ubiquitin-protein ligase e3a; UBE3AOMIM


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