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	> Protein (NX_Q05193) Protein (NX_Q05193) Protein Gene Symbol DNM1 to neXtProt (NX_Q05193) Description Dynamin-1 Chromosome 9 Location 9q34.11 (130965658 ~ 131017527) to Ensembl Sequene Features : Isoforms 5, Variants 77, PTMs 12 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .clathrin-mediated endocytosis .ephrin receptor signaling pathway .receptor internalization   + 4 more... .poly(A) RNA binding .identical protein binding .protein kinase binding   + 2 more... .extracellular exosome .membrane coat .plasma membrane .microtubule Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 5 77 12 2014-09-19 protein level 5 61 12 2014-05-27 protein level 5 61 14 2014-02-25 protein level 5 61 14 2013-12-09 protein level 5 55 14 2013-11-01 protein level 5 49 13 2013-09-12 protein level 5 49 13 2013-08-17 protein level 5 49 13 2013-07-15 protein level 5 30 13 2013-06-11 protein level 5 30 13 2013-02-12 protein level 5 15 40 2012-12-20 protein level 5 14 40 2012-10-30 protein level 5 14 40 2012-10-07 protein level 5 14 8 2012-08-24 protein level 5 14 8 2012-07-28 protein level 5 14 8 2012-06-08 protein level 5 5 8 2012-05-07 protein level 5 5 8 2012-04-10 protein level 5 5 8 2012-01-13 protein level 5 5 8 2011-12-20 protein level 5 5 8 2011-11-11 protein level 5 5 7 2011-08-23 protein level 5 5 7 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q05193-1 0 32 9 97346.6956 NX_Q05193-2 0 32 9 97201.6101 NX_Q05193-3 0 30 9 95980.0617 NX_Q05193-4 1 30 9 96336.2303 NX_Q05193-5 0 30 9 95834.9762 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-713135,EBI-389883 NCK1     .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation .negative regulation of PERK-mediated unfolded protein response   + 23 more... .eukaryotic initiation factor eIF2 binding .receptor tyrosine kinase binding .protein binding, bridging   + 5 more... .vesicle membrane .cell-cell junction .plasma membrane   + 6 more... 2 EBI-713135,EBI-466029 HTT     .negative regulation of extrinsic apoptotic signaling pathway .iron ion homeostasis .L-glutamate import   + 38 more... .diazepam binding .beta-tubulin binding .dynein intermediate chain binding   + 6 more... .protein complex .cytoplasmic vesicle membrane .dendrite   + 11 more... 3 EBI-713135,EBI-401755 GRB2     .positive regulation of reactive oxygen species metabolic process .cellular response to ionizing radiation .branching involved in labyrinthine layer morphogenesis   + 25 more... .ephrin receptor binding .poly(A) RNA binding .insulin receptor substrate binding   + 6 more... .Grb2-EGFR complex .extracellular exosome .vesicle membrane   + 10 more... 4 EBI-713135,EBI-5323863 LRRK2     .negative regulation of peroxidase activity .regulation of synaptic vesicle exocytosis .regulation of branching morphogenesis of a nerve   + 64 more... .protein kinase A binding .ion channel binding .protein homodimerization activity   + 18 more... .extracellular exosome .membrane raft .perikaryon   + 25 more... 5 EBI-713135,EBI-1391643 NOSTRIN     .regulation of nitric-oxide synthase activity .nitric oxide metabolic process .negative regulation of transcription, DNA-templated   + 3 more... .DNA binding .endocytic vesicle membrane .plasma membrane .cytoskeleton .nucleus 6 EBI-713135,EBI-2481535 SNX33     .positive regulation of protein localization to cell surface .negative regulation of protein localization to cell surface .membrane tubulation   + 12 more... .identical protein binding .phosphatidylinositol binding .cytoplasmic vesicle membrane .extrinsic component of membrane .cytoplasmic membrane-bounded vesicle   + 3 more... 7 EBI-713135,EBI-1111248 FNBP1     .endocytosis .identical protein binding .lipid binding .cytoplasmic membrane-bounded vesicle .cell cortex .coated pit   + 3 more... 8 EBI-713135,EBI-77848 SNX9     .membrane tubulation .lipid tube assembly .positive regulation of membrane protein ectodomain proteolysis   + 11 more... .Arp2/3 complex binding .protein homodimerization activity .phosphatidylinositol binding   + 2 more... .extracellular exosome .extrinsic component of cytoplasmic side of plasma membrane .cytoplasmic vesicle membrane   + 7 more... EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* ascites 50 bone marrow 41 brain 239 connective tissue 33 embryonic tissue 28 eye 57 heart 11 intestine 21 kidney 14 larynx 42 lung 17 lymph node 11 mammary gland 13 muscle 9 nerve 321 ovary 19 pancreas 51 parathyroid 97 placenta 14 prostate 10 skin 4 testis 9 thymus 12 thyroid 21 uterus 4 Health State Tissues TPM* normal 85 breast (mammary gland) tumor 10 chondrosarcoma 12 colorectal tumor 35 gastrointestinal tumor 16 germ cell tumor 18 glioma 93 head and neck tumor 14 kidney tumor 29 leukemia 10 non-neoplasia 62 ovarian tumor 26 pancreatic tumor 66 primitive neuroectodermal tumor of the CNS 39 prostate cancer 9 retinoblastoma 43 soft tissue/muscle tissue tumor 15 Developmental Stage Tissues TPM* adult 47 embryoid body 14 blastocyst 16 fetus 44 juvenile 89 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 9.8 adrenal gland 7.6 appendix 5.3 cerebral cortex 143.2 colon 4.2 duodenum 2.1 esophagus 4 gallbladder 21.8 heart muscle 2.7 kidney 5.6 lung 2.9 lymph node 2.8 pancreas 3.6 placenta 3.9 prostate 4.2 salivary gland 2.7 skin 9.5 small intestine 5.5 spleen 1.3 stomach 3.8 testis 2.5 urinary bladder 6.2 Tissues Tissues Expression level cerebellum High cerebral cortex High colon Low fallopian tube Low hippocampus High liver Low lung Low Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*602377, gene) Dynamin 1; DNM1 OMIM

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