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> Protein (NX_Q05193)
Protein (NX_Q05193)
Protein
Gene SymbolDNM1 to neXtProt (NX_Q05193)
DescriptionDynamin-1
Chromosome9
Location9q34.11 (130965658 ~ 131017527) to Ensembl
Sequene Features : Isoforms 5, Variants 77, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 77 12
2014-09-19protein level
5 61 12
2014-05-27protein level
5 61 14
2014-02-25protein level
5 61 14
2013-12-09protein level
5 55 14
2013-11-01protein level
5 49 13
2013-09-12protein level
5 49 13
2013-08-17protein level
5 49 13
2013-07-15protein level
5 30 13
2013-06-11protein level
5 30 13
2013-02-12protein level
5 15 40
2012-12-20protein level
5 14 40
2012-10-30protein level
5 14 40
2012-10-07protein level
5 14 8
2012-08-24protein level
5 14 8
2012-07-28protein level
5 14 8
2012-06-08protein level
5 5 8
2012-05-07protein level
5 5 8
2012-04-10protein level
5 5 8
2012-01-13protein level
5 5 8
2011-12-20protein level
5 5 8
2011-11-11protein level
5 5 7
2011-08-23protein level
5 5 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05193-1
0 32 9 97346.6956
NX_Q05193-2
0 32 9 97201.6101
NX_Q05193-3
0 30 9 95980.0617
NX_Q05193-4
1 30 9 96336.2303
NX_Q05193-5
0 30 9 95834.9762
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-713135,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
2 EBI-713135,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-713135,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-713135,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
5 EBI-713135,EBI-1391643 NOSTRIN  
  .regulation of nitric-oxide synthase activity
.nitric oxide metabolic process
.negative regulation of transcription, DNA-templated
  + 3 more...
.DNA binding .endocytic vesicle membrane
.plasma membrane
.cytoskeleton
.nucleus
6 EBI-713135,EBI-2481535 SNX33  
  .positive regulation of protein localization to cell surface
.negative regulation of protein localization to cell surface
.membrane tubulation
  + 12 more...
.identical protein binding
.phosphatidylinositol binding
.cytoplasmic vesicle membrane
.extrinsic component of membrane
.cytoplasmic membrane-bounded vesicle
  + 3 more...
7 EBI-713135,EBI-1111248 FNBP1  
  .endocytosis .identical protein binding
.lipid binding
.cytoplasmic membrane-bounded vesicle
.cell cortex
.coated pit
  + 3 more...
8 EBI-713135,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bone marrow41
brain239
connective tissue33
embryonic tissue28
eye57
heart11
intestine21
kidney14
larynx42
lung17
lymph node11
mammary gland13
muscle9
nerve321
ovary19
pancreas51
parathyroid97
placenta14
prostate10
skin4
testis9
thymus12
thyroid21
uterus4
Health State
TissuesTPM*
normal85
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor35
gastrointestinal tumor16
germ cell tumor18
glioma93
head and neck tumor14
kidney tumor29
leukemia10
non-neoplasia62
ovarian tumor26
pancreatic tumor66
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma43
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult47
embryoid body14
blastocyst16
fetus44
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland7.6
appendix5.3
cerebral cortex143.2
colon4.2
duodenum2.1
esophagus4
gallbladder21.8
heart muscle2.7
kidney5.6
lung2.9
lymph node2.8
pancreas3.6
placenta3.9
prostate4.2
salivary gland2.7
skin9.5
small intestine5.5
spleen1.3
stomach3.8
testis2.5
urinary bladder6.2
Tissues
TissuesExpression level
cerebellumHigh
cerebral cortexHigh
colonLow
fallopian tubeLow
hippocampusHigh
liverLow
lungLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602377, gene) Dynamin 1; DNM1OMIM


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