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> Protein (NX_Q05209)
Protein (NX_Q05209)
Protein
Gene SymbolPTPN12 to neXtProt (NX_Q05209)
DescriptionTyrosine-protein phosphatase non-receptor type 12
Chromosome7
Location7q11.23 (77166592 ~ 77269388) to Ensembl
Sequene Features : Isoforms 3, Variants 92, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.SH3 domain binding
.non-membrane spanning protein tyrosine phosphatase activity
.cell projection
.cell junction
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 92 22
2014-09-19protein level
3 76 22
2014-05-27protein level
3 75 22
2014-02-25protein level
2 76 22
2013-12-09protein level
2 61 22
2013-11-01protein level
2 59 22
2013-09-12protein level
2 59 23
2013-08-17protein level
2 59 23
2013-07-15protein level
2 39 23
2013-06-11protein level
2 39 23
2013-02-12protein level
1 21 21
2012-12-20protein level
1 21 21
2012-10-30protein level
1 27 21
2012-10-07protein level
1 27 21
2012-08-24protein level
1 25 21
2012-07-28protein level
1 25 21
2012-06-08protein level
1 27 21
2012-05-07protein level
1 15 21
2012-04-10protein level
1 15 21
2012-01-13protein level
1 10 21
2011-12-20protein level
1 10 21
2011-11-11protein level
1 10 20
2011-08-23protein level
1 10 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05209-1
6 35 0 88051.1889
NX_Q05209-2
0 34 0 72732.259
NX_Q05209-3
0 35 0 74091.9814
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2266035,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-2266035,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-2266035,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
4 EBI-2266035,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
5 EBI-2266035,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
6 EBI-2266035,EBI-2257090 TEK  
  .negative regulation of endothelial cell apoptotic process
.regulation of endothelial cell apoptotic process
.positive regulation of actin cytoskeleton reorganization
  + 45 more...
.ATP binding
.receptor activity
.transmembrane receptor protein tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane raft
.apical plasma membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
bladder66
blood49
bone139
bone marrow41
brain29
cervix20
connective tissue67
ear186
embryonic tissue112
esophagus99
eye28
heart33
intestine34
kidney47
liver77
lung77
lymph node55
mammary gland79
mouth120
muscle65
nerve321
ovary39
pancreas14
pituitary gland60
placenta74
prostate52
salivary gland49
skin33
spleen56
stomach83
testis57
thymus75
thyroid21
trachea77
uterus86
vascular38
Health State
TissuesTPM*
normal51
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma120
colorectal tumor62
esophageal tumor115
gastrointestinal tumor84
germ cell tumor75
glioma18
head and neck tumor52
kidney tumor58
leukemia63
liver tumor135
lung tumor19
non-neoplasia82
ovarian tumor39
pancreatic tumor28
prostate cancer86
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor87
uterine tumor44
Developmental Stage
TissuesTPM*
adult77
embryoid body142
blastocyst97
neonate64
fetus43
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue47.7
adrenal gland31.9
appendix47.3
bone marrow44.3
cerebral cortex20.2
colon27.6
duodenum19.2
esophagus41.7
gallbladder46.9
heart muscle28.9
kidney24.5
liver19.3
lung63.9
lymph node28.8
ovary32.9
pancreas9.2
placenta63.1
prostate23.5
salivary gland12.1
skin35.8
small intestine23.6
spleen50.8
stomach21
testis32.8
thyroid gland31.8
urinary bladder40
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600079, gene) Protein-tyrosine phosphatase, nonreceptor-type, 12; PTPN12OMIM


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