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> Protein (NX_Q05329)
Protein (NX_Q05329)
Protein
Gene SymbolGAD2 to neXtProt (NX_Q05329)
DescriptionGlutamate decarboxylase 2
Chromosome10
Location10p12.1 (26505236 ~ 26593487) to Ensembl
Sequene Features : Isoforms 1, Variants 122, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to drug
.neurotransmitter biosynthetic process
.neurotransmitter secretion
  + 2 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.perinuclear region of cytoplasm
.presynaptic membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 122 7
2014-09-19protein level
1 91 7
2014-05-27protein level
1 91 7
2014-02-25protein level
1 91 7
2013-12-09protein level
1 80 7
2013-11-01protein level
1 74 7
2013-09-12protein level
1 74 7
2013-08-17protein level
1 74 7
2013-07-15protein level
1 47 7
2013-06-11protein level
1 47 7
2013-02-12protein level
1 22 7
2012-12-20protein level
1 22 7
2012-10-30protein level
1 27 7
2012-10-07protein level
1 27 7
2012-08-24protein level
1 26 7
2012-07-28protein level
1 26 7
2012-06-08protein level
1 26 7
2012-05-07protein level
1 19 7
2012-04-10protein level
1 19 7
2012-01-13protein level
1 15 7
2011-12-20protein level
1 15 7
2011-11-11protein level
1 15 7
2011-08-23protein level
1 15 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05329-1
23 0 1 65368.2692
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9304251,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
2 EBI-9304251,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
3 EBI-9304251,EBI-944295 MAL2  
  .N/A .N/A .extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 3 more...
4 EBI-9304251,EBI-7055862 TMEM159  
  .N/A .N/A .integral component of membrane
5 EBI-9304251,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain20
lung14
pancreas365
testis2
Health State
TissuesTPM*
normal23
germ cell tumor34
glioma9
non-neoplasia20
pancreatic tumor114
Developmental Stage
TissuesTPM*
adult4
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex12.9
pancreas2
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowLow
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonLow
duodenumLow
epididymisLow
fallopian tubeLow
gallbladderLow
heart muscleLow
kidneyLow
lateral ventricleMedium
lungLow
nasopharynxLow
ovaryLow
pancreasHigh
parathyroid glandLow
placentaLow
prostateMedium
rectumLow
salivary glandLow
seminal vesicleLow
skin 1Medium
skin 2Low
small intestineLow
testisLow
thyroid glandLow
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*138275, gene) Glutamate decarboxylase 2; GAD2OMIM


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