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> Protein (NX_Q05397)
Protein (NX_Q05397)
Protein
Gene SymbolPTK2 to neXtProt (NX_Q05397)
DescriptionFocal adhesion kinase 1
Chromosome8
Location8q24.3 (141667999 ~ 142012315) to Ensembl
Sequene Features : Isoforms 7, Variants 131, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 131 18
2014-09-19protein level
6 105 18
2014-05-27protein level
6 105 18
2014-02-25protein level
6 104 18
2013-12-09protein level
6 88 18
2013-11-01protein level
6 87 18
2013-09-12protein level
6 87 18
2013-08-17protein level
6 87 18
2013-07-15protein level
6 59 18
2013-06-11protein level
6 59 18
2013-02-12protein level
6 29 134
2012-12-20protein level
6 31 134
2012-10-30protein level
6 40 134
2012-10-07protein level
6 40 35
2012-08-24protein level
6 25 35
2012-07-28protein level
6 25 35
2012-06-08protein level
6 11 35
2012-05-07protein level
6 11 35
2012-04-10protein level
6 11 35
2012-01-13protein level
6 11 35
2011-12-20protein level
4 8 33
2011-11-11protein level
4 8 32
2011-08-23protein level
4 8 32
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q05397-1
0 45 1 119156.9571
NX_Q05397-2
1 37 1 99294.7238
NX_Q05397-3
3 21 1 63160.4685
NX_Q05397-4
0 17 1 48935.4971
NX_Q05397-5
2 43 1 120822.801
NX_Q05397-6
0 16 0 39849.0562
NX_Q05397-7
1 44 1 114179.6468
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-702142,EBI-1051449 TGFB1I1  
  .positive regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.cell fate commitment
  + 12 more...
.I-SMAD binding
.androgen receptor binding
.Roundabout binding
  + 2 more...
.nuclear matrix
.focal adhesion
.cytoskeleton
  + 2 more...
2 EBI-702142,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-702142,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
4 EBI-702142,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
5 EBI-702142,EBI-9834454 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
6 EBI-702142,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
7 EBI-702142,EBI-1026718 FLT1  
  .embryonic morphogenesis
.blood vessel morphogenesis
.vascular endothelial growth factor receptor signaling pathway
  + 20 more...
.placental growth factor-activated receptor activity
.VEGF-B-activated receptor activity
.VEGF-A-activated receptor activity
  + 4 more...
.receptor complex
.focal adhesion
.integral component of plasma membrane
  + 3 more...
8 EBI-702142,EBI-702104 EPHA2  
  .activation of GTPase activity
.positive regulation of establishment of protein localization to plasma membrane
.response to growth factor
  + 31 more...
.ATP binding
.ephrin receptor activity
.transmembrane receptor protein tyrosine kinase activity
.ruffle membrane
.lamellipodium membrane
.leading edge membrane
  + 4 more...
9 EBI-702142,EBI-7399369 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
10 EBI-702142,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
11 EBI-702142,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
12 EBI-702142,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
13 EBI-702142,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
14 EBI-702142,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
15 EBI-702142,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
16 EBI-702142,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
17 EBI-702142,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
18 EBI-702142,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
19 EBI-702142,EBI-1056751 PTRH2  
  .negative regulation of anoikis
.positive regulation of anoikis
.negative regulation of gene expression
  + 2 more...
.aminoacyl-tRNA hydrolase activity .membrane
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites125
bladder234
blood16
bone139
bone marrow102
brain265
cervix103
connective tissue73
ear62
embryonic tissue145
esophagus198
eye62
heart122
intestine202
kidney147
larynx255
liver38
lung101
lymph node189
mammary gland112
mouth362
muscle84
nerve64
ovary88
pancreas60
pituitary gland121
placenta116
prostate73
skin75
spleen74
stomach94
testis153
thymus87
thyroid214
tonsil58
trachea328
uterus124
vascular38
Health State
TissuesTPM*
normal157
adrenal tumor79
bladder carcinoma341
breast (mammary gland) tumor150
cervical tumor144
chondrosarcoma96
colorectal tumor284
esophageal tumor231
gastrointestinal tumor118
germ cell tumor121
glioma65
head and neck tumor276
kidney tumor333
leukemia84
liver tumor10
lung tumor29
lymphoma41
non-neoplasia72
ovarian tumor144
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
prostate cancer67
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor55
uterine tumor122
Developmental Stage
TissuesTPM*
adult132
embryoid body100
blastocyst227
fetus77
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.3
adrenal gland38.7
appendix25.9
bone marrow4.7
cerebral cortex65.1
colon36.8
duodenum28.3
esophagus30.1
gallbladder40.4
heart muscle34.3
kidney39.5
liver19.5
lung44.1
lymph node28.4
ovary35.4
pancreas20.1
placenta65.9
prostate34.3
salivary gland35.9
skin24.1
small intestine31.7
spleen26.3
stomach33.8
testis49.7
thyroid gland48.9
urinary bladder52.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600758, gene) Protein-tyrosine kinase, cytoplasmic; PTK2OMIM


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